Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

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Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1028468472
P356DOI10.1186/1471-2180-8-39
P932PMC publication ID2289824
P698PubMed publication ID18304359
P5875ResearchGate publication ID5548831

P50authorTimothy StinearQ30347065
Ashley MansellQ37376445
Benjamin P. HowdenQ37837894
P2093author name stringJohn K Davies
Paul D R Johnson
Peter B Ward
Danielle J Smith
P2860cites workMacrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation stateQ24291852
Recognition of Staphylococcus aureus by the innate immune systemQ24530569
BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data.Q24792694
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
Inhibition of rot translation by RNAIII, a key feature of agr functionQ28255084
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1Q28271523
TM4: a free, open-source system for microarray data management and analysisQ29547339
Global regulation of Staphylococcus aureus genes by RotQ31123861
DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.Q33220466
Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markers.Q33264418
Antimicrobial peptides from plateletsQ33338526
Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) functionQ33883752
Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A.Q33959130
Reversion of the glycopeptide resistance phenotype in Staphylococcus aureus clinical isolatesQ33978642
Characterization of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental backgroundsQ33978671
Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with plateletsQ34003911
Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycinQ34107062
Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA.Q34116833
Transcription Profiling of the mgrA Regulon in Staphylococcus aureusQ34509922
Coordinated and differential control of aureolysin (aur) and serine protease (sspA) transcription in Staphylococcus aureus by sarA, rot and agr (RNAIII).Q34539527
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistanceQ34547868
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencingQ34630593
In vivo survival of teicoplanin-resistant Staphylococcus aureus and fitness cost of teicoplanin resistanceQ34721614
Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureusQ34747322
The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus.Q34762753
Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycinQ34823746
Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremiaQ35023343
Mgr, a novel global regulator in Staphylococcus aureusQ35098154
Staphylococcus aureus capsular polysaccharidesQ35630504
Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002Q35872823
Low-level vancomycin resistance in Staphylococcus aureus--an Australian perspective.Q36025384
Vancomycin-resistant staphylococci and enterococci: epidemiology and controlQ36178104
Complement-dependent platelet injury by staphylococcal protein AQ36271673
The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureusQ36381504
The interaction of bacterial pathogens with plateletsQ36482515
Modulation of fibronectin adhesins and other virulence factors in a teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureusQ36670735
Variation in the expression of cell wall proteins of Staphylococcus aureus grown on solid and liquid mediaQ37003585
Extensive and genome-wide changes in the transcription profile of Staphylococcus aureus induced by modulating the transcription of the cell wall synthesis gene murF.Q38306144
Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization methodQ38314636
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureusQ38352516
Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50.Q39474811
An international multicenter study of antimicrobial resistance and typing of hospital Staphylococcus aureus isolates from 21 laboratories in 19 countries or statesQ39632724
Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureusQ40345457
Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycinQ41867637
Lack of relationship between purine biosynthesis and vancomycin resistance in Staphylococcus aureus: a cautionary tale for microarray interpretationQ42112243
Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus.Q42112516
Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditionsQ42181494
Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibilityQ43433837
Purification and characterization of urease from Helicobacter pyloriQ43729113
Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulonQ44605321
Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal proteinQ45023859
Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemiaQ46933141
Strain dependence of the cell wall-damage induced stimulon in Staphylococcus aureusQ57614225
Expression of staphylococcal protein Sbi is induced by human IgGQ73920116
Genetic analysis of the cap5 locus of Staphylococcus aureusQ77908317
Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and plateletsQ80805583
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophilsQ81180246
P4510describes a project that useslimmaQ112236343
P921main subjectStaphylococcus aureusQ188121
vancomycinQ424027
methicillin-resistant Staphylococcus aureusQ595158
bacterial evolutionQ115395667
P304page(s)39
P577publication date2008-02-27
P1433published inBMC MicrobiologyQ15759430
P1476titleDifferent bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia
P478volume8

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cites work (P2860)
Q30455758A mutation in the PP2C phosphatase gene in a Staphylococcus aureus USA300 clinical isolate with reduced susceptibility to vancomycin and daptomycin
Q64263426Absence of Protein A Expression Is Associated With Higher Capsule Production in Staphylococcal Isolates
Q98665067Acapsular Staphylococcus aureus with a non-functional agr regains capsule expression after passage through the bloodstream in a bacteremia mouse model
Q37277083Acquired vancomycin resistance in clinically relevant pathogens
Q34648042Additional routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing, transcriptional profiling, and phenotypic studies
Q36882486Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus
Q35745676An association between bacterial genotype combined with a high-vancomycin minimum inhibitory concentration and risk of endocarditis in methicillin-resistant Staphylococcus aureus bloodstream infection
Q24596120Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure
Q34057548Characterization of heterogeneous vancomycin-intermediate resistance, MIC and accessory gene regulator (agr) dysfunction among clinical bloodstream isolates of staphyloccocus aureus
Q37124131Clinical Outcomes in Patients with Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Bloodstream Infection
Q38425879Clinical implications of vancomycin heteroresistant and intermediately susceptible Staphylococcus aureus
Q30401758Coagulase-negative staphylococci.
Q36964857Comparative proteomics-based identification of genes associated with glycopeptide resistance in clinically derived heterogeneous vancomycin-intermediate Staphylococcus aureus strains
Q36969754Decreased vancomycin susceptibility in Staphylococcus aureus caused by IS256 tempering of WalKR expression
Q92003682Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms
Q35432686Early agr activation correlates with vancomycin treatment failure in multi-clonotype MRSA endovascular infections
Q39555150Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.
Q28477900Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR
Q33501860Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen
Q42782239Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF/VraSR.
Q35728976Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
Q36932920Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus
Q37717901Heterogeneous vancomycin resistance in Staphylococcus aureus: a review of epidemiology, diagnosis, and clinical significance
Q36589269Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis
Q38958136Increased Endovascular Staphylococcus aureus Inoculum Is the Link Between Elevated Serum Interleukin 10 Concentrations and Mortality in Patients With Bacteremia
Q39218893Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria
Q35105880Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2
Q50132676Metabolic Mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility
Q90700039Methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in Taiwan
Q33500363Molecular features of heterogeneous vancomycin-intermediate Staphylococcus aureus strains isolated from bacteremic patients
Q49453092Mutation of Agr Is Associated with the Adaptation of Staphylococcus aureus to the Host during Chronic Osteomyelitis
Q37575024Novel Mutation Sites in the Development of Vancomycin- Intermediate Resistance in Staphylococcus aureus
Q41776452Population Genomics of Reduced Vancomycin Susceptibility in Staphylococcus aureus.
Q34632683Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility
Q24646677Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
Q36644897Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure.
Q36153912Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus
Q46236730Severe infections emerge from commensal bacteria by adaptive evolution
Q37809666Systematic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates
Q94566860The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications
Q42914487Treatment of Infections Caused By Antimicrobial-Resistant Gram-Positive Bacteria
Q33604815Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection
Q34108614Underestimation of vancomycin and teicoplanin MICs by broth microdilution leads to underdetection of glycopeptide-intermediate isolates of Staphylococcus aureus.
Q95355781Vancomycin Resistance in Staphylococcus aureus
Q33945397Vancomycin heteroresistance is associated with reduced mortality in ST239 methicillin-resistant Staphylococcus aureus blood stream infections.
Q37236231Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system
Q42280738Vancomycin tolerance in methicillin-resistant Staphylococcus aureus: influence of vancomycin, daptomycin, and telavancin on differential resistance gene expression
Q42358800VraR Binding to the Promoter Region of agr Inhibits Its Function in Vancomycin-Intermediate Staphylococcus aureus (VISA) and Heterogeneous VISA.
Q51247058WalK(S221P), a naturally occurring mutation, confers vancomycin resistance in VISA strain XN108.
Q28478770Whole genome sequencing and complete genetic analysis reveals novel pathways to glycopeptide resistance in Staphylococcus aureus

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