Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis

scientific article

Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2008PLoSO...3.1915F
P356DOI10.1371/JOURNAL.PONE.0001915
P932PMC publication ID2271052
P698PubMed publication ID18382686
P5875ResearchGate publication ID5469386

P50authorNicholas FunderburgQ56562708
Benigno RodriguezQ42870636
P2093author name stringWei Jiang
Michael M Lederman
Angel A Luciano
Scott F Sieg
P2860cites workTLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.Q51973780
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.Q51990275
Toll-dependent control mechanisms of CD4 T cell activation.Q51996404
Maintenance of serological memory by polyclonal activation of human memory B cells.Q52008907
Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory CellsQ57447880
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadQ58034113
Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome?Q70211252
HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytesQ72688555
Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signalingQ80499984
Toll-like receptors: linking innate and adaptive immunityQ81808287
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Q24310398
Toll-like receptor control of the adaptive immune responsesQ29547305
Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactionsQ34078687
Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patientsQ35575683
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.Q35828692
Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patientsQ35833022
CD69 is an immunoregulatory molecule induced following activationQ36061024
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infectionQ36229666
Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIVQ36369802
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.Q36399551
Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotidesQ38289912
Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infectionQ39737687
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organsQ40307375
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.Q41611623
MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligandsQ41877481
Early reduction of immune activation in lymphoid tissue following highly active HIV therapyQ44178152
Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagementQ46534179
CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV+ adolescent populationQ47674962
CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiencyQ47684550
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremiaQ48023288
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
toll-like receptorQ408004
T cell activationQ14863969
P304page(s)e1915
P577publication date2008-04-02
P1433published inPLOS OneQ564954
P1476titleToll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
P478volume3

Reverse relations

cites work (P2860)
Q37204104A role for TLR signaling during B cell activation in antiretroviral-treated HIV individuals
Q36076533A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection
Q34293455A toll-like receptor 9 antagonist improves bladder function and white matter sparing in spinal cord injury
Q37162262An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection
Q35531527Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection
Q58609021Bystander T Cells: A Balancing Act of Friends and Foes
Q92857870CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy
Q45906567Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation.
Q34171589Circulating sCD14 is associated with virological response to pegylated-interferon-alpha/ribavirin treatment in HIV/HCV co-infected patients
Q28066226Close Encounters of Lymphoid Cells and Bacteria
Q58122552Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production
Q33700312Contrasting roles for TLR ligands in HIV-1 pathogenesis
Q54218397Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.
Q33602906Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.
Q33943390Cytomegalovirus-specific responses of CD38⁺ memory T cells are skewed towards IFN-γ and dissociated from CD154 in HIV-1 infection
Q37349847Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients.
Q35392417Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production
Q37122279Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy
Q89399169Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy
Q31146636Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine
Q38788604FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells.
Q30698666FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression
Q34007172Good cell, bad cell: flow cytometry reveals T-cell subsets important in HIV disease
Q41814282HIV Infection and TLR Signalling in the Liver
Q36186538HIV pathogenesis: the host
Q42207253HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.
Q36352592HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro
Q33450665HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers
Q33359564HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
Q50130203Haemophilia, human immunodeficiency virus and human immunodeficiency virus pathogenesis
Q40075506Host and Viral Factors in HIV-Mediated Bystander Apoptosis
Q90740831Human labour is associated with altered regulatory T cell function and maternal immune activation
Q42285768Human β defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons
Q35557198Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
Q34707229Immunomodulatory effects of polysaccharide from marine fungus Phoma herbarum YS4108 on T cells and dendritic cells.
Q37444276Immunopathogenesis of AIDS.
Q36032021Impact of HMGB1/TLR Ligand Complexes on HIV-1 Replication: Possible Role for Flagellin during HIV-1 Infection
Q36952930Impaired toll-like receptor 8 signaling in multiple sclerosis
Q35214189Increased microbial translocation in ≤ 180 days old perinatally human immunodeficiency virus-positive infants as compared with human immunodeficiency virus-exposed uninfected infants of similar age.
Q35823171Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression
Q33597485Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
Q36665377Increased toll-like receptor signaling pathways characterize CD8+ cells in rapidly progressive SIV infection
Q37827571Induction of innate immune responses in the female genital tract: friend or foe of HIV-1 infection?
Q33997880Innate immune recognition and activation during HIV infection
Q37777344Insights into the role of Toll-like receptors in modulation of T cell responses
Q34145979Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
Q38234839Intestinal barrier dysfunction in HIV infection: pathophysiology, clinical implications and potential therapies
Q36807121Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines
Q36154801Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.
Q34545417Mechanisms of HIV-associated lymphocyte apoptosis: 2010
Q33713895Microbial translocation and cardiometabolic risk factors in HIV infection
Q35872112Microbial translocation and microbiome dysbiosis in HIV-associated immune activation
Q36558287Microbial translocation in the pathogenesis of HIV infection and AIDS.
Q36501286Microbial translocation, immune activation, and HIV disease
Q36089230Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity
Q34038531Oral infectious diseases: a potential risk factor for HIV virus recrudescence?
Q33715552Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections
Q50450148Phenotypic differences of CD4(+) T cells in response to red blood cell immunization in transfused sickle cell disease patients.
Q37309633Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
Q34056881Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals
Q92867311Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis
Q30235024Recent Insights into the HIV/AIDS Pandemic
Q34296062Reduction of immune activation with chloroquine therapy during chronic HIV infection
Q34020121Residual immune dysregulation syndrome in treated HIV infection
Q35780966Role of in vitro stimulation with lipopolysaccharide on T-cell activation in HIV-infected antiretroviral-treated patients
Q37513027Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy
Q41849777T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication
Q34430776T-cell phenotypes, apoptosis and inflammation in HIV+ patients on virologically effective cART with early atherosclerosis
Q37215125TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+ T cells
Q45384441TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells
Q61447562TLR9 polymorphism correlates with immune activation, CD4 decline and plasma IP10 levels in HIV patients
Q24644783The lymph node in HIV pathogenesis
Q53687316Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.
Q37686199Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
Q31057328Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis

Search more.