| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/BIES.20151 |
| P698 | PubMed publication ID | 15551269 |
| P50 | author | Pierre De Meyts | Q18209260 |
| P2860 | cites work | Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways. | Q34438574 |
| The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate | Q41624239 | ||
| On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. | Q52464078 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 1351-1362 | |
| P577 | publication date | 2004-12-01 | |
| P1433 | published in | BioEssays | Q4914614 |
| P1476 | title | Insulin and its receptor: structure, function and evolution | |
| P478 | volume | 26 |
| Q60046062 | A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism |
| Q35600773 | A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism |
| Q41859170 | A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II. |
| Q41448228 | A receptor state space model of the insulin signalling system in glucose transport. |
| Q38796334 | A review for clinicians: Prostate cancer and the antineoplastic properties of metformin |
| Q24608585 | Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I |
| Q31112505 | All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors |
| Q53123409 | All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element. |
| Q90185093 | An Efficient Method for Generating Murine Hypothalamic Neurospheres for the Study of Regional Neural Progenitor Biology |
| Q58024148 | An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors |
| Q36558126 | An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti |
| Q42218166 | Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma |
| Q34140959 | Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative |
| Q33979757 | Blood glucose regulation during prolonged, submaximal, continuous exercise: a guide for clinicians |
| Q46681884 | Cloning and characterization of an mRNA encoding an insulin receptor from the horned scarab beetle Onthophagus nigriventris (Coleoptera: Scarabaeidae). |
| Q42136307 | Closing in on a mechanism for activation |
| Q40163133 | Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer |
| Q41682209 | Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26. |
| Q43126193 | Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains |
| Q38759920 | Developmental therapeutics for patients with breast cancer and central nervous system metastasis: current landscape and future perspectives. |
| Q34069086 | Diabetes and cancer II: role of diabetes medications and influence of shared risk factors. |
| Q59085964 | Diet boosts the effectiveness of a cancer drug |
| Q40166251 | Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors. |
| Q50522724 | Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics. |
| Q38818418 | Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamics |
| Q42646874 | Evolution of the insulin receptor family and receptor isoform expression in vertebrates. |
| Q33830301 | Evolution of the vertebrate insulin receptor substrate (Irs) gene family |
| Q37777069 | Exciting New Targets in Lung Cancer Therapy: ALK, IGF-1R, HDAC, and Hh |
| Q34905649 | Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor |
| Q53173338 | Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R. |
| Q37650277 | Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways |
| Q24656036 | Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation |
| Q35240427 | How IGF-1 activates its receptor |
| Q24609714 | How insulin engages its primary binding site on the insulin receptor |
| Q38018441 | Hypervalent nonbonded interactions of a divalent sulfur atom. Implications in protein architecture and the functions |
| Q42081392 | IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor |
| Q36609185 | Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor |
| Q36427446 | In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells |
| Q33572235 | Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity |
| Q38315801 | Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta |
| Q34207699 | Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms |
| Q30538044 | Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B |
| Q29619495 | Insulin and insulin-like growth factor signalling in neoplasia |
| Q48522961 | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells. |
| Q91260434 | Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2 |
| Q38965191 | Insulin mimetic peptide S371 folds into a helical structure. |
| Q54394289 | Insulin receptor-insulin interaction kinetics using multiplex surface plasmon resonance. |
| Q26314671 | Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA |
| Q38063325 | Insulin signalling to the kidney in health and disease. |
| Q46347435 | Insulin-induced enhancement of MCF-7 breast cancer cell response to 5-fluorouracil and cyclophosphamide |
| Q53525637 | Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression. |
| Q33359945 | Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation |
| Q90161695 | Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus |
| Q21131284 | Landmarks in insulin research |
| Q34014659 | Mammary gland growth factors: roles in normal development and in cancer |
| Q38689022 | Metformin and pancreatic cancer: Is there a role? |
| Q40555570 | MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc |
| Q35858451 | Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding |
| Q58591653 | Molecular evolution and functional characterisation of Insulin Related Peptides in molluscs: contributions of Crassostrea gigas genomic and transcriptomic-wide screening |
| Q37403947 | Molecular mechanisms of differential intracellular signaling from the insulin receptor |
| Q90316511 | Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses |
| Q37897324 | New insights into the signaling system and function of insulin in fish |
| Q42167608 | New target genes for the peroxisome proliferator-activated receptor-γ (PPARγ) antitumour activity: Perspectives from the insulin receptor |
| Q91721416 | Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus |
| Q38037191 | Peptides and peptide conjugates: therapeutics on the upward path |
| Q47930345 | Positive selection has driven the evolution of the Drosophila insulin-like receptor (InR) at different timescales |
| Q40144763 | Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells |
| Q34510776 | Proinsulin in development: New roles for an ancient prohormone. |
| Q34477488 | Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo |
| Q38014940 | Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems |
| Q37603286 | Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes |
| Q46562142 | Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells |
| Q36962066 | Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. |
| Q37690868 | Silencing of Two Insulin Receptor Genes Disrupts Nymph-Adult Transition of Alate Brown Citrus Aphid |
| Q47965403 | Small Scaffolds, Big Potential: Developing Miniature Proteins as Therapeutic Agents |
| Q27665357 | Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation |
| Q34719875 | Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor |
| Q88488120 | Structural basis for the poisonous activity of a predator's venom insulin |
| Q41863848 | Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins. |
| Q42114223 | Structural determinants of the insulin receptor-related receptor activation by alkali |
| Q24613113 | Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists |
| Q34564193 | Structure of the insulin receptor ectodomain reveals a folded-over conformation |
| Q58705586 | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones |
| Q38932846 | Synthesis and Identification of FITC-Insulin Conjugates Produced Using Human Insulin and Insulin Analogues for Biomedical Applications |
| Q28731843 | Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues |
| Q33951057 | Targeting insulin-like growth factor axis in hepatocellular carcinoma |
| Q24633750 | Targeting the insulin growth factor receptor 1 |
| Q37903335 | Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies |
| Q90479239 | The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease |
| Q90568479 | The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer |
| Q53676952 | The association between insulin and low-density lipoprotein receptors. |
| Q27026813 | The association between type 2 diabetes mellitus and women cancer: the epidemiological evidences and putative mechanisms |
| Q28072970 | The challenge of developmental therapeutics for adrenocortical carcinoma |
| Q35034188 | The effects of anti-insulin antibodies and cross-reactivity with human recombinant insulin analogues in the E170 insulin immunometric assay |
| Q34944353 | The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity |
| Q43489034 | The human insulin superfamily of polypeptide hormones |
| Q37984217 | The insulin and insulin-like growth factor receptor family in neoplasia: an update |
| Q38137808 | The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation |
| Q34409899 | The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes. |
| Q38561423 | The road to the first, fully active and more stable human insulin variant with an additional disulfide bond. |
| Q35688212 | The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression |
| Q38354696 | Theoretical and computational studies of peptides and receptors of the insulin family |
| Q50288396 | Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2). |
| Q28485499 | UV-light exposure of insulin: pharmaceutical implications upon covalent insulin dityrosine dimerization and disulphide bond photolysis |
| Q61810256 | Unraveling the Regulation of Hepatic Gluconeogenesis |
| Q30990290 | Unusual duplication of the insulin-like receptor in the crustacean Daphnia pulex |
| Q26823601 | Venus kinase receptors: prospects in signaling and biological functions of these invertebrate kinases |
| Q37551918 | β-Adrenergic Receptor and Insulin Resistance in the Heart |
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