| scholarly article | Q13442814 |
| P2093 | author name string | Harish Vashisth | |
| Cameron F. Abrams | |||
| P2860 | cites work | Landmarks in Insulin Research | Q21131284 |
| Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists | Q24613113 | ||
| Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation | Q24656036 | ||
| String method for the study of rare events | Q27355543 | ||
| The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice | Q27648393 | ||
| Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS | Q27650044 | ||
| X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue. | Q27650913 | ||
| Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS | Q27654364 | ||
| Receptor binding redefined by a structural switch in a mutant human insulin | Q27656530 | ||
| Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS | Q27657527 | ||
| Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues | Q27659590 | ||
| Kinetic evidence for the sequential association of insulin binding sites 1 and 2 to the insulin receptor and the influence of receptor isoform | Q27662597 | ||
| Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue | Q27734124 | ||
| A structural switch in a mutant insulin exposes key residues for receptor binding 1 1Edited by A. R. Fersht | Q27759218 | ||
| The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix | Q27766023 | ||
| All-atom empirical potential for molecular modeling and dynamics studies of proteins | Q27860468 | ||
| VMD: visual molecular dynamics | Q27860554 | ||
| Scalable molecular dynamics with NAMD | Q27860718 | ||
| Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes | Q28615460 | ||
| Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations | Q29547631 | ||
| Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain | Q31156781 | ||
| Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding | Q33326284 | ||
| Insulin and its receptor: structure, function and evolution | Q33340596 | ||
| High-affinity insulin binding: insulin interacts with two receptor ligand binding sites | Q33642814 | ||
| Large-scale conformational sampling of proteins using temperature-accelerated molecular dynamics | Q33740100 | ||
| Structural biology of insulin and IGF1 receptors: implications for drug design | Q34152764 | ||
| Insulin interactions with its receptors: experimental evidence for negative cooperativity. | Q34207711 | ||
| The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. | Q34315974 | ||
| Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues | Q34378129 | ||
| Structure of the insulin receptor ectodomain reveals a folded-over conformation | Q34564193 | ||
| The insulin receptor: a prototype for dimeric, allosteric membrane receptors? | Q34798186 | ||
| The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity | Q34944353 | ||
| Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks | Q34956682 | ||
| Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor | Q34960169 | ||
| Adventures with Insulin in the Islets of Langerhans | Q34978853 | ||
| Insulin receptor knockout mice | Q35019765 | ||
| "DFG-flip" in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop. | Q35895098 | ||
| α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase | Q36094246 | ||
| The insulin and EGF receptor structures: new insights into ligand-induced receptor activation. | Q36729032 | ||
| Insulin receptor structure and its implications for the IGF-1 receptor | Q36938900 | ||
| Structural insights into ligand-induced activation of the insulin receptor. | Q37048796 | ||
| Single-chain insulins as receptor agonists | Q37176283 | ||
| A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies | Q37614858 | ||
| Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families | Q38004270 | ||
| Functional reconstitution of insulin receptor binding site from non-binding receptor fragments | Q38291056 | ||
| Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity. | Q38302676 | ||
| High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper | Q38309461 | ||
| Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro | Q38354202 | ||
| Receptor-binding region of insulin | Q39975406 | ||
| Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer | Q40163133 | ||
| Characterization of the functional insulin binding epitopes of the full-length insulin receptor | Q40440929 | ||
| Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis | Q41368833 | ||
| Transmembrane domain interactions are necessary for negative cooperativity of the insulin receptor | Q41432506 | ||
| Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor | Q41589386 | ||
| Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation | Q41909279 | ||
| A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor | Q42176585 | ||
| Using enhanced sampling and structural restraints to refine atomic structures into low-resolution electron microscopy maps | Q42233985 | ||
| Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains | Q43126193 | ||
| Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change | Q43260043 | ||
| Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies | Q43903257 | ||
| Peptides identify the critical hotspots involved in the biological activation of the insulin receptor | Q43966301 | ||
| Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity | Q44363229 | ||
| Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. | Q44955728 | ||
| How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. | Q44995090 | ||
| Revisiting the finite temperature string method for the calculation of reaction tubes and free energies. | Q45998116 | ||
| A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides. | Q46002534 | ||
| Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama. | Q46407645 | ||
| Single-sweep methods for free energy calculations | Q46557517 | ||
| Transition pathways in complex systems: Application of the finite-temperature string method to the alanine dipeptide | Q46751297 | ||
| All-atom structural models for complexes of insulin-like growth factors IGF1 and IGF2 with their cognate receptor | Q46940541 | ||
| Simplified and improved string method for computing the minimum energy paths in barrier-crossing events | Q51915792 | ||
| Finite temperature string method for the study of rare events | Q51937295 | ||
| String method in collective variables: minimum free energy paths and isocommittor surfaces | Q51937459 | ||
| Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer | Q59069006 | ||
| Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin | Q59088375 | ||
| Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions | Q67939215 | ||
| Dynamics of a monomeric insulin analogue: testing the molten-globule hypothesis | Q70556976 | ||
| Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit | Q70937602 | ||
| Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule | Q71985130 | ||
| A model for insulin binding to the insulin receptor | Q72415947 | ||
| Ligand-induced conformational change in the minimized insulin receptor | Q73053749 | ||
| Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit | Q73280020 | ||
| Alanine scanning mutagenesis of insulin | Q73335000 | ||
| Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule | Q73402401 | ||
| Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding | Q73450444 | ||
| The Disulfide Bonds in the C-terminal Domains of the Human Insulin Receptor Ectodomain | Q73876950 | ||
| Characterization of a second ligand binding site of the insulin receptor | Q79824277 | ||
| The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state | Q79975107 | ||
| Direct determination of the insulin-insulin receptor interface using transferred cross-saturation experiments | Q82912826 | ||
| Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability | Q83917455 | ||
| Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain | Q83954122 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 1017-1030 | |
| P577 | publication date | 2013-02-27 | |
| P1433 | published in | Proteins | Q7251514 |
| P1476 | title | All‐atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone‐binding element | |
| P478 | volume | 81 |
| Q31112505 | All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors |
| Q41203690 | Building Graphs To Describe Dynamics, Kinetics, and Energetics in the d-ALa:d-Lac Ligase VanA. |
| Q37697030 | Collective variable approaches for single molecule flexible fitting and enhanced sampling |
| Q51114729 | Comparison between Mean Forces and Swarms-of-Trajectories String Methods. |
| Q35007870 | Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. |
| Q57943282 | Enhanced Sampling in Molecular Dynamics Using Metadynamics, Replica-Exchange, and Temperature-Acceleration |
| Q27322857 | Exploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network model |
| Q34905649 | Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor |
| Q38965191 | Insulin mimetic peptide S371 folds into a helical structure. |
| Q35858451 | Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding |
| Q38354696 | Theoretical and computational studies of peptides and receptors of the insulin family |
Search more.