Telomeric position effect--a third silencing mechanism in eukaryotes

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Telomeric position effect--a third silencing mechanism in eukaryotes is …
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scholarly articleQ13442814

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P819ADS bibcode2008PLoSO...3.3864D
P356DOI10.1371/JOURNAL.PONE.0003864
P932PMC publication ID2587703
P698PubMed publication ID19057646
P5875ResearchGate publication ID23572556

P2093author name stringJ Greg Doheny
Randy Mottus
Thomas A Grigliatti
P2860cites workFunctional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31Q22009388
Regulation of chromatin structure by site-specific histone H3 methyltransferasesQ24290115
The Polycomb group protein EZH2 directly controls DNA methylationQ24299020
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
Effects of tethering HP1 to euchromatic regions of the Drosophila genome.Q52604132
Role of Drosophila HP1 in euchromatic gene expression.Q52655216
Three distinct chromatin domains in telomere ends of polytene chromosomes in Drosophila melanogaster Tel mutantsQ56626913
DNA end-joining: from yeast to manQ63362924
Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome 2L in Drosophila melanogasterQ70458710
Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogasterQ71575385
Chromatin structure of the histone genes of D. melanogasterQ72882351
Controlled expression of tagged proteins in Drosophila using a new modular P-element vector system.Q52576172
Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains.Q52597044
DNA organization and polymorphism of a wild-type Drosophila telomere regionQ46130621
Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotesQ46408897
The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II.Q46486956
Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sitesQ47070155
The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeastQ47072158
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behaviorQ47072690
Mechanisms of HP1-mediated gene silencing in DrosophilaQ47296769
Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.Q50142372
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing.Q52020343
The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis.Q52193077
Isolation and characterization of second chromosome mutagen-sensitive mutations in Drosophila melanogaster.Q52257611
Characterization of mutations that enhance position-effect variegation in Drosophila melanogaster.Q52452938
Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome.Q52459356
The effect of histone gene deletions on chromatin structure in Saccharomyces cerevisiae.Q52488400
Mutants affecting position-effect heterochromatinization in Drosophila melanogaster.Q52527754
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeastQ27936427
latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutantQ28117657
SAP - a putative DNA-binding motif involved in chromosomal organizationQ28145637
MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activationQ28210381
Histone methyltransferase activity of a Drosophila Polycomb group repressor complexQ29615394
A Deficiency Screen for Dominant Suppressors of Telomeric Silencing in DrosophilaQ30051074
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3.Q30159543
A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogasterQ30446014
The sequence of the Drosophila regulatory gene Suppressor two of zesteQ30450770
The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensationQ30453594
Chromatin boundaries in budding yeast: the nuclear pore connectionQ30709842
From silencing to gene expression: real-time analysis in single cellsQ30784143
Histone H3.3 is enriched in covalent modifications associated with active chromatinQ33196967
Two distinct domains in Drosophila melanogaster telomeresQ33222851
Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal locationQ33589879
Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor IQ33775938
The HP1 protein family: getting a grip on chromatinQ33885013
SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegationQ33887366
Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical rolesQ33891148
Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiersQ33944585
The maternal effect gene, abnormal oocyte (abo), of Drosophila melanogaster encodes a specific negative regulator of histonesQ33947040
Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effectQ33954518
A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogasterQ33959013
The hinge and chromo shadow domain impart distinct targeting of HP1-like proteinsQ33967856
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexesQ34059541
Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger proteinQ34149551
Drosophila telomeric transgenes provide insights on mechanisms of gene silencingQ34212997
Control of telomere elongation and telomeric silencing in Drosophila melanogasterQ34213022
Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogasterQ34278471
The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegationQ34300558
Position effect variegation in Drosophila is associated with an altered chromatin structure.Q34311285
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA.Q34322170
Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.Q34366059
Maintenance of gene expression patternsQ34392966
Histone H3 variants specify modes of chromatin assemblyQ34444033
From genetics to epigenetics: the tale of Polycomb group and trithorax group genesQ34544784
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferaseQ34570027
Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.Q34602120
Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegationQ34608754
Modifiers of terminal deficiency-associated position effect variegation in Drosophila.Q34614525
A role for the Drosophila SU(VAR)3-9 protein in chromatin organization at the histone gene cluster and in suppression of position-effect variegationQ34616676
Telomeric associated sequences of Drosophila recruit polycomb-group proteins in vivo and can induce pairing-sensitive repressionQ34617502
The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein familyQ35079217
Heterochromatin, position effects, and the genetic dissection of chromatin.Q35543807
Position effect and related phenomenaQ35653449
Division of labor in polycomb group repressionQ35874471
Epigenetic inheritance of chromatin states mediated by Polycomb and trithorax group proteins in Drosophila.Q36120650
Chromosome ends: different sequences may provide conserved functions.Q36162100
Epigenome programming by Polycomb and Trithorax proteins.Q36164758
In the end, it's all structureQ36172513
The mechanism of telomere protection: a comparison between Drosophila and humans.Q36192029
Euchromatic and heterochromatic domains at Drosophila telomeresQ36226153
Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin.Q36381425
Position-effect variegation--an assay for nonhistone chromosomal proteins and chromatin assembly and modifying factorsQ36542352
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylationQ36719239
Drosophila telomeres: A variation on the telomerase themeQ37280500
Position-effect variegation after 60 yearsQ37793926
Analysis of mammalian telomere position effectQ39378042
Histone gene deficiencies and position–effect variegation in DrosophilaQ39695671
Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cellsQ39996922
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.Q40014061
puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaQ40442820
The heterochromatin protein 1 prevents telomere fusions in DrosophilaQ40989792
Heterochromatin and gene regulation in DrosophilaQ41044078
The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with PolycombQ41089141
Molecular model for telomeric heterochromatin in yeastQ41477020
The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity.Q41607049
Chromosome ends: all the same under their caps.Q41703496
Telomere position effect in human cellsQ43642023
Overexpression of the SuUR gene induces reversible modifications at pericentric, telomeric and intercalary heterochromatin of Drosophila melanogaster polytene chromosomesQ44232724
MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complexQ44455868
A Dnmt2-like protein mediates DNA methylation in DrosophilaQ44565976
Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of DrosophilaQ44969634
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectHeterochromatin Protein 1c Dmel_CG6990Q29818712
Heterochromatin Protein 1e Dmel_CG8120Q29818811
P304page(s)e3864
P577publication date2008-12-05
P1433published inPLOS OneQ564954
P1476titleTelomeric position effect--a third silencing mechanism in eukaryotes
P478volume3