Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy

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Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy is …
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scholarly articleQ13442814

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P356DOI10.1200/JCO.2010.29.5865
P698PubMed publication ID21172893

P50authorHope RugoQ55975497
Joyce O'ShaughnessyQ88307619
P2093author name stringHoward A Burris
Maoxia Zheng
Svetislava J Vukelja
Ian E Krop
Yu-Waye Chu
Charles L Vogel
Lukas Amler
Sandhya Girish
Steven Limentani
Elizabeth Tan-Chiu
Barbara Klencke
Rachel A Borson
Richard A Michaelson
P2860cites workTargeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugateQ34880994
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
breast cancerQ128581
Erb-b2 receptor tyrosine kinase 2Q415271
P304page(s)398-405
P577publication date2010-12-20
P1433published inJournal of Clinical OncologyQ400292
P1476titlePhase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
P478volume29

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cites work (P2860)
Q429066448(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.
Q33442957A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates
Q57911965A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy
Q46349887A cancer trial scandal and its regulatory backlash
Q37571113A general approach to site-specific antibody drug conjugates
Q28487973A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma
Q28544636A mechanistic tumor penetration model to guide antibody drug conjugate design
Q33430299A multicenter Phase II study evaluating the efficacy, safety and pharmacokinetics of trastuzumab emtansine in Japanese patients with heavily pretreated HER2-positive locally recurrent or metastatic breast cancer
Q54507904A phase 1 study of weekly dosing of trastuzumab emtansine (T-DM1) in patients with advanced human epidermal growth factor 2-positive breast cancer.
Q40835274A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma
Q33402778A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer
Q41344028A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real-world experience
Q38644521A review of HER2-targeted therapy in breast and ovarian cancer: lessons from antiquity - CLEOPATRA and PENELOPE.
Q36740744A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
Q33886306Ado-Trastuzumab Emtansine in Metastatic HER2-Positive Breast Cancer.
Q34389275Ado-trastuzumab emtansine (T-DM1) in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer: latest evidence and clinical potential
Q33414335Ado-trastuzumab emtansine (T-DM1): a novel antibody-drug conjugate for the treatment of HER2-positive metastatic breast cancer
Q37378269Ado-trastuzumab emtansine and radium 223 dichloride
Q33415915Ado-trastuzumab emtansine-associated telangiectasias in metastatic breast cancer: a case series
Q38235934Ado-trastuzumab emtansine: a HER2-positive targeted antibody-drug conjugate
Q37601692Advances and future directions in the targeting of HER2-positive breast cancer: implications for the future.
Q35989963Advances in first-line treatment for patients with HER-2+ metastatic breast cancer
Q49885166Adverse Events of Trastuzumab Emtansine (T-DM1) in the Treatment of HER2-Positive Breast Cancer Patients
Q57452661Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing
Q43175985American Association of Pharmaceutical Scientists National Biotechnology Conference Short Course: Translational Challenges in Developing Antibody-Drug Conjugates: May 24, 2012, San Diego, CA.
Q44026744Amplification and overexpression of the ABCC3 (MRP3) gene in primary breast cancer
Q57291727An HER3-targeting antibody-drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC
Q54439772An integrated multiple-analyte pharmacokinetic model to characterize trastuzumab emtansine (T-DM1) clearance pathways and to evaluate reduced pharmacokinetic sampling in patients with HER2-positive metastatic breast cancer.
Q36938365Anti-HER2 Therapy Beyond Second-Line for HER2-Positive Metastatic Breast Cancer: A Short Review and Recommendations for Several Clinical Scenarios from a Spanish Expert Panel
Q47750583Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer
Q90171453Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer
Q35889630Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties
Q39210427Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review
Q47568807Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future
Q53739135Antibody-Drug Conjugates for Cancer Therapy.
Q46209550Antibody-Drug Conjugates: Pharmacokinetic/Pharmacodynamic Modeling, Preclinical Characterization, Clinical Studies, and Lessons Learned.
Q26800175Antibody-drug conjugates as novel anti-cancer chemotherapeutics
Q38864720Antibody-drug conjugates for cancer therapy.
Q38334139Antibody-drug conjugates: a mini-review. The synopsis of two approved medicines.
Q38239854Antibody-drug conjugates: an emerging modality for the treatment of cancer
Q38665425Antibody-mediated delivery of therapeutics for cancer therapy.
Q38856969Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).
Q46866013Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.
Q47743713Bevacizumab confers additional advantage to the combination of trastuzumab plus pertuzumab in trastuzumab‑refractory breast cancer model
Q37947902Beyond trastuzumab: new treatment options for HER2-positive breast cancer
Q35653820Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer
Q43751494Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics
Q38408138Biomedical applications of trastuzumab: as a therapeutic agent and a targeting ligand.
Q35068522Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics.
Q51108833Breast Cancer Immunotherapy.
Q38215394Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines.
Q37833497Breast cancer in 2010: Novel targets and therapies for a personalized approach
Q38072263Breast cancer in 2012: New drugs, new knowledge, new targets
Q39428826Breast cancer treatment-induced cardiotoxicity
Q37098302Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity
Q54586053Can patients with metastatic breast cancer be cured after introduction of newer and more effective agents?
Q38791220Cardiac Complications of HER2-Targeted Therapies in Breast Cancer
Q38852051Cell-specific biomarkers and targeted biopharmaceuticals for breast cancer treatment
Q90212189Challenges in Optimising the Successful Construction of Antibody Drug Conjugates in Cancer Therapy
Q26774513Changing strategies for target therapy in gastric cancer
Q90484961Clinical development of immunotherapies for HER2+ breast cancer: a review of HER2-directed monoclonal antibodies and beyond
Q36653094Clinical efficacy and safety of T-DM1 for patients with HER2-positive breast cancer
Q24632855Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer
Q27005742Co-development of diagnostic vectors to support targeted therapies and theranostics: essential tools in personalized cancer therapy
Q39564060Combination radioimmunotherapy and chemoimmunotherapy involving different or the same targets improves therapy of human pancreatic carcinoma xenograft models
Q37995939Combining immunotherapy and targeted therapies in cancer treatment
Q93039741Current Development of Monoclonal Antibodies in Cancer Therapy
Q37733237Current and Emerging Treatment Regimens for HER2-Positive Breast Cancer
Q37946797Current and emerging targeted therapies for metastatic breast cancer
Q37330128Current approaches and future directions in the treatment of HER2-positive breast cancer
Q35584741Current targeted therapies in breast cancer: clinical applications in the elderly woman
Q38137253Design and evaluation of radiolabeled tracers for tumor imaging
Q38017203Designing immunoconjugates for cancer therapy
Q38624597Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.
Q34114794Discovery of internalizing antibodies to tumor antigens from phage libraries
Q33421995Dose-reduced trastuzumab emtansine: active and safe in acute hepatic dysfunction
Q38084826Drug conjugates such as Antibody Drug Conjugates (ADCs), immunotoxins and immunoliposomes challenge daily clinical practice.
Q38061647Drug-conjugated antibodies for the treatment of cancer
Q37940203Dual HER2-targeted approaches in HER2-positive breast cancer
Q34169075Effect and safety of dual anti-human epidermal growth factor receptor 2 therapy compared to monotherapy in patients with human epidermal growth factor receptor 2-positive breast cancer: a systematic review
Q39816545Effects of Trastuzumab Emtansine (T-DM1) on QT Interval and Safety of Pertuzumab Plus T-DM1 in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer
Q47136161Efficacy and safety of trastuzumab emtansine (T-DM1) in the treatment of HER2-positive metastatic breast cancer (MBC): a meta-analysis of randomized controlled trial
Q38119307Emerging approaches for treating HER2-positive metastatic breast cancer beyond trastuzumab
Q92768203Engineering a HER2-specific antibody-drug conjugate to increase lysosomal delivery and therapeutic efficacy
Q46873437EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer
Q60950660EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma
Q38073792Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy.
Q33433942Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer
Q38920359Evolving Strategies for Target Selection for Antibody-Drug Conjugates
Q90212184Factors Affecting the Pharmacology of Antibody-Drug Conjugates
Q37066113Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.
Q42337744Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany
Q49056513From linear 'dogma' and trastuzumab-emtansine to future transcriptional circuitry-based drug discovery for breast cancer
Q34619403GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer
Q41694155Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma.
Q35576706HER2 expression and efficacy of T-DM1
Q53691004HER2 genomic amplification in circulating tumor DNA and estrogen receptor positivity predict primary resistance to trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer.
Q33358380HER2-positive breast cancer: a new piece of the puzzle
Q30524836High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production
Q27025863Human epidermal growth factor receptor family-targeted therapies in the treatment of HER2-overexpressing breast cancer
Q42732010IBC's 21st Annual Antibody Engineering and 8th Annual Antibody Therapeutics International Conferences and 2010 Annual Meeting of the Antibody Society. December 5-9, 2010, San Diego, CA USA.
Q38042256Immunoconjugates and long circulating systems: origins, current state of the art and future directions
Q38787696Immunotherapy for breast cancer: past, present, and future
Q57134389Immunotherapy of breast cancer
Q37998453Improving treatment of HER2-positive cancers: opportunities and challenges
Q38557525In vivo biotransformations of antibody-drug conjugates
Q26771931Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population: A Review, Part 1
Q36088788Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications
Q92457343Lacrimal drainage system stenosis associated with Trastuzumab emtansine (Kadcyla®, T-DM1) administration: a case report
Q57495756Late Administration of Trastuzumab Emtansine Might Lead to Loss of Chance for Better Outcome in Patients with HER2-Positive Metastatic Breast Cancer
Q37029370Linked-in: design and efficacy of antibody drug conjugates in oncology
Q37698957Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models
Q37859389Luteinizing hormone-releasing hormone receptor targeted agents for prostate cancer
Q38233292Management of patients with HER2-positive metastatic breast cancer: is there an optimal sequence of HER2-directed approaches?
Q38255064Mechanism-based cancer therapy: resistance to therapy, therapy for resistance
Q35624814Mechanisms of Trastuzumab resistance in ErbB2-driven breast cancer and newer opportunities to overcome therapy resistance
Q38204975Mechanistic considerations for the use of monoclonal antibodies for cancer therapy.
Q38960075Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates
Q90048092Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes
Q56624496Metastasiertes Mammakarzinom
Q38186568MicroRNAs: master regulators of drug resistance, stemness, and metastasis.
Q37631514Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat?
Q38071374Monoclonal antibodies in oncology therapeutics: present and future indications
Q94475380Narrowing the focus: Therapeutic cell surface targets for refractory triple-negative breast cancer
Q35111429Natural compounds' activity against cancer stem-like or fast-cycling melanoma cells
Q92953592Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo
Q37016382New developments in the treatment of HER2-positive breast cancer
Q37144315New strategies in HER2-overexpressing breast cancer: many combinations of targeted drugs available
Q33579636Next generation of antibody therapy for cancer
Q26747729Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine
Q57106864Novel treatment strategies for patients with HER2-positive breast cancer who do not benefit from current targeted therapy drugs
Q36366709Ocular Adverse Events Associated with Antibody-Drug Conjugates in Human Clinical Trials
Q39112394On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach
Q38152742Optimal sequencing of anti-HER2 therapy throughout the continuum of HER2-positive breast cancer: evidence and clinical considerations
Q48131836Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
Q37580443Outcomes of re-treatment with first-line trastuzumab plus a taxane in HER2 positive metastatic breast cancer patients after (neo)adjuvant trastuzumab: A prospective multicenter study
Q30544833Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.
Q36408570Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer
Q38017732Overcoming treatment resistance in HER2-positive breast cancer: potential strategies.
Q45006316PK assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine
Q36653978Particle shape enhances specificity of antibody-displaying nanoparticles
Q37241496Personalizing therapies for gastric cancer: molecular mechanisms and novel targeted therapies
Q38132237Pertuzumab for the treatment of metastatic breast cancer
Q27851691Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
Q38022192Pharmacokinetic considerations for antibody drug conjugates
Q90211749Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients
Q44895959Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer.
Q33418305Phase I and pharmacokinetic study of trastuzumab emtansine in Japanese patients with HER2-positive metastatic breast cancer
Q36934332Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with advanced melanoma
Q36582681Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
Q38220276Pneumonitis and pulmonary fibrosis associated with breast cancer treatments.
Q33954595Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implications of the effect of covariates.
Q37671599Potential of antibody-drug conjugates and novel therapeutics in breast cancer management.
Q38271031Pragmatic issues in biomarker evaluation for targeted therapies in cancer
Q38131563Preclinical and clinical pharmacokinetic/pharmacodynamic considerations for antibody-drug conjugates
Q27015048Profiling and targeting HER2-positive breast cancer using trastuzumab emtansine
Q35343184Quantitative measurement of HER2 expression in breast cancers: comparison with 'real-world' routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival
Q64991628Quantitative pharmacology in antibody-drug conjugate development: armed antibodies or targeted small molecules?
Q34308692Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers
Q37248289RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation
Q38199128Recent advances and future trends in the targeted therapy of metastatic gastric cancer
Q28083123Recent advances in the development of anti-HER2 antibodies and antibody-drug conjugates
Q37950515Recent developments in treatment stratification for metastatic breast cancer
Q34500802Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer
Q41037554Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer
Q92413714Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer
Q39591068Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer
Q35591518Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications
Q35747298Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM1 in women with HER2-positive metastatic breast cancer
Q27003258Role of trastuzumab emtansine in the treatment of HER2-positive breast cancer
Q33441316Safety Evaluation of Trastuzumab Emtansine in Japanese Patients with HER2-Positive Advanced Breast Cancer
Q33430735Safety and Efficacy of Trastuzumab Emtansine in Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: a Meta-analysis
Q37100575Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer
Q27007849Serum biomarkers for the detection of cardiac toxicity after chemotherapy and radiation therapy in breast cancer patients
Q44829143Site-specific chemical modification of antibody fragments using traceless cleavable linkers
Q57911963Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature
Q36256669Splenic Enlargement and Bone Marrow Hyperplasia in Patients Receiving Trastuzumab-Emtansine for Metastatic Breast Cancer
Q30590270Strategies for modern biomarker and drug development in oncology
Q38103883Strategies to address drug interaction potential for antibody-drug conjugates in clinical development
Q34028831Synergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticles
Q39685521T-DM1 Activity in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers That Received Prior Therapy With Trastuzumab and Pertuzumab
Q35268982TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation
Q35612933Targeted T-cell Therapy in Stage IV Breast Cancer: A Phase I Clinical Trial
Q47559665Targeted Therapies Against Growth Factor Signaling in Breast Cancer
Q35687574Targeted Therapies in Breast Cancer: Implications for Advanced Oncology Practice.
Q38058816Targeted drug delivery for cancer therapy: the other side of antibodies
Q35372584Targeted therapies for breast cancer
Q36245324Targeted therapies in breast cancer: are heart and vessels also being targeted?
Q38007119Targeted therapy for gastric cancer.
Q35208654Targeting the HER/EGFR/ErbB family to prevent breast cancer.
Q37862077Targeting the human EGFR family in esophagogastric cancer
Q37974246Targeting the subtypes of breast cancer: rethinking investigational drugs
Q46431111The HER2 CISH pharmDx(™) Kit in the assessment of breast cancer patients for anti-HER2 treatment
Q36064912The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer
Q37992829The adjuvant treatment of HER2-positive breast cancer
Q36745332The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia.
Q38092648The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics
Q27021990The development of immunoconjugates for targeted cancer therapy
Q84560547The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
Q38686601The future of antiviral immunotoxins
Q36097890The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma
Q33840201The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells.
Q34412979The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists?
Q36180078The potential for trastuzumab emtansine in human epidermal growth factor receptor 2 positive metastatic breast cancer: latest evidence and ongoing studies
Q38018259The role of targeted therapy and biomarkers in breast cancer treatment
Q33409083The success story of trastuzumab emtansine, a targeted therapy in HER2-positive breast cancer
Q89700506Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer
Q50896680Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study.
Q39068453Trastuzumab Emtansine With or Without Pertuzumab Versus Trastuzumab Plus Taxane for Human Epidermal Growth Factor Receptor 2-Positive, Advanced Breast Cancer: Primary Results From the Phase III MARIANNE Study.
Q35875708Trastuzumab and Gemcitabine in Pretreated HER2 Overexpressing Metastatic Breast Cancer Patients: Retrospective Analysis of Our Series
Q38052616Trastuzumab as first-line therapy in HER2-positive metastatic breast cancer patients
Q35034559Trastuzumab beyond progression in HER2-positive advanced breast cancer: the Royal Marsden experience
Q38974785Trastuzumab cardiotoxicity: from clinical trials to experimental studies
Q27851917Trastuzumab emtansine for HER2-positive advanced breast cancer
Q38417241Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer
Q38088038Trastuzumab emtansine in breast cancer
Q33415375Trastuzumab emtansine in the treatment of HER2-positive metastatic breast cancer in Japanese patients
Q27853001Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial
Q38198573Trastuzumab emtansine: a review of its use in patients with HER2-positive advanced breast cancer previously treated with trastuzumab-based therapy
Q47795804Trastuzumab emtansine: determining its role in management of HER2+ breast cancer
Q38101890Trastuzumab emtansine: first global approval
Q33759627Trastuzumab emtansine: mechanisms of action and drug resistance
Q37387449Trastuzumab emtansine: the first targeted chemotherapy for treatment of breast cancer
Q35891822Trastuzumab for HER2-Positive Metastatic Breast Cancer: Clinical and Economic Considerations
Q36585636Trastuzumab-DM1: a clinical update of the novel antibody-drug conjugate for HER2-overexpressing breast cancer
Q35869998Trastuzumab-induced corneal ulceration: successful no-drug treatment of a "blind" side effect in a case report.
Q36220464Trastuzumab: a novel standard option for patients with HER-2-positive advanced gastric or gastro-oesophageal junction cancer
Q34326536Treating breast cancer in the 21st century: emerging biological therapies
Q35740877Treatment of HER2-positive breast cancer.
Q37962332Treatment of HER2-positive breast cancer: current status and future perspectives.
Q38162127Trends in cancer-targeted antibody-drug conjugates.
Q36252918Trends in translational medicine and drug targeting and delivery: new insights on an old concept-targeted drug delivery with antibody-drug conjugates for cancers
Q38086872Tubulin: an example of targeted chemotherapy
Q38094627Tumour vasculature targeting agents in hybrid/conjugate drugs
Q28079391Twenty years of anti-HER2 therapy-associated cardiotoxicity
Q38014920Using antibodies to target cancer therapeutics
Q38262066Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates
Q42174238Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells
Q37576694When Standard Therapy Fails in Breast Cancer: Current and Future Options for HER2-Positive Disease
Q28067696Whether HER2-positive non-breast cancers are candidates for treatment with Ado-trastuzumab emtansine?
Q39794283[89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer

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