Tubulin: an example of targeted chemotherapy

scientific article published on March 2013

Tubulin: an example of targeted chemotherapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4155/FMC.12.217
P698PubMed publication ID23464522

P2093author name stringChris Twelves
Jenny Seligmann
P2860cites workEribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instabilityQ24610709
Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationaleQ26851529
A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patientsQ46627004
Expression of class III {beta}-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy.Q46630298
BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instabilityQ46919957
Taxol: mechanisms of action and resistanceQ48421472
Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumorQ49135477
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).Q52196656
Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer.Q52548541
Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer.Q53144257
Mitosis is not a key target of microtubule agents in patient tumors.Q53271035
Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel.Q53442602
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.Q53599393
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast CancerQ56626150
Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, in Patients With Taxane-Resistant Metastatic Breast CancerQ58614874
Halichondrins - antitumor polyether macrolides from a marine spongeQ62773345
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological propertiesQ71236147
Microtubule-binding agents: a dynamic field of cancer therapeuticsQ27690249
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancerQ27851549
Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinomaQ28235707
Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatmentQ28255226
Preclinical discovery of ixabepilone, a highly active antineoplastic agentQ28272975
Abiraterone and increased survival in metastatic prostate cancerQ29617512
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialQ29620155
Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxelQ31152523
Pharmacological effects of formulation vehicles : implications for cancer chemotherapyQ33187648
Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)Q33361186
A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer.Q33375329
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancerQ33389302
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapyQ33393360
A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabineQ33401523
Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10.Q33561943
North Central Cancer Treatment Group (NCCTG) N0432: phase II trial of docetaxel with capecitabine and bevacizumab as first-line chemotherapy for patients with metastatic breast cancerQ33618149
Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancerQ33852049
Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxaneQ33990883
Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancerQ34203414
Structural insight into microtubule functionQ34301115
Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients.Q34522032
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trialQ34632818
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugateQ34880994
Phase 3 study of docosahexaenoic acid–paclitaxel versus dacarbazine in patients with metastatic malignant melanomaQ35003419
Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS.Q35098563
A common pharmacophore for cytotoxic natural products that stabilize microtubulesQ35123238
Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropeniaQ35148088
Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivoQ35559041
Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trialsQ35747285
Development of pharmacogenomic markers to select preoperative chemotherapy for breast cancerQ36109584
Eribulin mesylate in patients with refractory cancers: a Phase I studyQ36205403
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivoQ36231650
Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cellsQ36291736
Peripheral neuropathy induced by microtubule-stabilizing agents.Q36436422
Exploiting the enhanced permeability and retention effect for tumor targetingQ36578875
Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancerQ36667452
Tumour targeting by microtubule-depolymerizing vascular disrupting agentsQ37008845
Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?Q37073084
Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapyQ37125330
Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulinQ37238550
Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignanciesQ37367110
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypesQ37372150
Significantly longer progression-free survival with nab-paclitaxel compared with docetaxel as first-line therapy for metastatic breast cancerQ37496425
From signaling pathways to microtubule dynamics: the key players.Q37661807
Microtubules and resistance to tubulin-binding agentsQ37690565
Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabineQ37777290
Chemotherapy-induced peripheral neuropathy: prevention and treatmentQ37911252
A phase II study of eribulin in Japanese patients with heavily pretreated metastatic breast cancerQ37944440
Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulinsQ38305006
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.Q39582682
Randomized multicenter phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancerQ39855292
Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasivenessQ39901043
Preclinical efficacy spectrum and pharmacokinetics of ixabepiloneQ40000960
In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteasesQ40241012
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.Q40322378
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
Macrocyclic ketone analogues of halichondrin B.Q40504671
Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancerQ42653377
Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathyQ43281593
Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubulesQ43921221
Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trialQ44102232
Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.Q44280070
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallographyQ45009271
Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors.Q45976200
Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel.Q45994576
Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxaneQ46059531
Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing.Q46068571
Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity.Q46119122
Phase I and pharmacokinetic study of XRP6258 (RPR 116258A), a novel taxane, administered as a 1-hour infusion every 3 weeks in patients with advanced solid tumorsQ46160687
Evolution of neuropathy and myopathy during intensive vincristine/corticosteroid chemotherapy for non-hodgkin's lymphomaQ46197928
Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trialQ46454181
Phase I/II study of ixabepilone plus capecitabine in anthracycline-pretreated/resistant and taxane-resistant metastatic breast cancerQ46466799
Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancerQ46507139
Morphological and morphometric analysis of paclitaxel and docetaxel-induced peripheral neuropathy in ratsQ46507706
Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancerQ46516617
P433issue3
P921main subjectchemotherapyQ974135
P304page(s)339-352
P577publication date2013-03-01
P1433published inFuture Medicinal ChemistryQ19280078
P1476titleTubulin: an example of targeted chemotherapy
P478volume5

Reverse relations

cites work (P2860)
Q387553222-Anilino-3-Aroylquinolines as Potent Tubulin Polymerization Inhibitors
Q61453755Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
Q58547427Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
Q35185097CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy
Q38963815Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors
Q58705926Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
Q46207470Differential involvement of glutathione S-transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids.
Q93087101Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
Q36996281Ferrocenyl 2,5-Piperazinediones as Tubulin-Binding Organometallic ABCB1 and ABCG2 Inhibitors Active against MDR Cells
Q38952778Microtubule destabilising agents: far more than just antimitotic anticancer drugs
Q38434222New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Q27011766Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis
Q49787954Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin
Q90163186Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine
Q59794796Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
Q40095321The size of the EB cap determines instantaneous microtubule stability

Search more.