Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin

scientific article published on 22 April 2009

Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2009.04.070
P932PMC publication ID2700829
P698PubMed publication ID19423340
P5875ResearchGate publication ID24409337

P50authorIwao OjimaQ1676049
P2093author name stringLiang Sun
Ezio Bombardelli
Cristiano Ferlini
Ilaria Zanardi
Antonella Pepe
Gabriele Fontana
Xinyuan Wu
P2860cites workRefined structure of alpha beta-tubulin at 3.5 A resolutionQ27636088
The Amber biomolecular simulation programsQ27860745
Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classesQ28298601
Using CLUSTAL for multiple sequence alignmentsQ29547794
Microtubule dynamics in vitro are regulated by the tubulin isotype compositionQ35910782
Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to TaxolQ36620261
Design, synthesis, and biological evaluation of new-generation taxoidsQ37325768
Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignanciesQ37367110
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypesQ37372150
Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistanceQ38287681
Structure and utilization of tubulin isotypesQ39544501
The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance.Q40444066
Personal recollections on the early development of taxolQ40585263
Kinetics of colchicine binding to purified beta-tubulin isotypes from bovine brainQ41126089
Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.Q41132286
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cellsQ41166048
Promotion of microtubule assembly in vitro by taxolQ41461193
Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.Q44280070
Structure-activity relationships of ring C-secotaxoids. 1. Acylative modificationsQ44778527
The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studiesQ47602343
Beta-tubulin isotypes purified from bovine brain have different relative stabilitiesQ48110685
Use of N,N'-polymethylenebis(iodoacetamide) derivatives as probes for the detection of conformational differences in tubulin isotypesQ48184460
Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain.Q48508305
Comparative modelling of human β tubulin isotypes and implications for drug binding.Q53635180
Synthesis and structure-activity relationships of new second-generation taxoidsQ59183369
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)3300-3304
P577publication date2009-04-22
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleNovel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin
P478volume19

Reverse relations

cites work (P2860)
Q373230432-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes
Q36104522AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer
Q33780549Characterization of the colchicine binding site on avian tubulin isotype betaVI.
Q38404084Class III β-tubulin in normal and cancer tissues
Q34143487Drug discovery targeting cell division proteins, microtubules and FtsZ.
Q38810389Effect of CH-35, a novel anti-tumor colchicine analogue, on breast cancer cells overexpressing the βIII isotype of tubulin.
Q64926957Microtubule targeting agents in glioma.
Q37689138New microtubule-inhibiting anticancer agents
Q39699060Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives
Q52690917Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
Q54035369Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.
Q92636365Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids
Q52667194Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
Q41573963Taxol®: The First Microtubule Stabilizing Agent
Q38086872Tubulin: an example of targeted chemotherapy

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