The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

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The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(13)70240-7
P698PubMed publication ID23810788

P50authorGeorge WildingQ5546267
Richard BairdQ42878560
Susana MirandaQ56450977
Shahneen K SandhuQ60042780
Carlo ToniattiQ86902984
Khin ThwayQ86996040
P2093author name stringJohann S de Bono
Robert M Wenham
Aurelius Omlin
Ruth Riisnaes
Stan B Kaye
Victor Moreno
Robert Iannone
Manash Chatterjee
William R Schelman
Heidrun Gevensleben
Martin Forster
Linda Sun
Christopher L Carpenter
Lucy Hylands
John Loughney
Nathan Kreischer
P2860cites workMechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancerQ24302687
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The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.Q27851580
Integrated genomic analyses of ovarian carcinomaQ27860518
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
Germline mutations in RAD51D confer susceptibility to ovarian cancerQ28245028
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancerQ28287454
The mutational landscape of lethal castration-resistant prostate cancerQ29614634
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialQ29619615
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trialQ30080035
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Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.Q34973214
FANCF methylation contributes to chemoselectivity in ovarian cancerQ35142957
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Dual roles of PARP-1 promote cancer growth and progressionQ36460391
A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancerQ37081107
Mutations in CHEK2 associated with prostate cancer riskQ37219438
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The DNA damage response and cancer therapyQ37977004
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneityQ38400993
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free intervalQ39712677
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumorsQ39782128
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Re: New guidelines to evaluate the response to treatment in solid tumors (ovarian cancer).Q47936662
NBS1 is a prostate cancer susceptibility gene.Q51029363
Dose-finding in phase I clinical trials based on toxicity probability intervals.Q51907391
Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.Q52623792
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Beyond Hormone Therapy for Prostate Cancer with PARP inhibitorsQ57693963
Accelerated titration designs for phase I clinical trials in oncologyQ73598986
P433issue9
P921main subjectphase I clinical trialQ5452194
P304page(s)882-892
P577publication date2013-06-28
P1433published inLancet Oncology CommissionQ13747613
P1476titleThe poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
P478volume14

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