Advances in the approach to novel drug clinical development for breast cancer

scientific article published on 23 April 2014

Advances in the approach to novel drug clinical development for breast cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/17460441.2014.911282
P698PubMed publication ID24758225

P2093author name stringCristiano Ferrario
Gerald Batist
P2860cites workPreoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27.Q46765380
Aromatase inhibitors: from bench to bedside and backQ46788411
Safety, pharmacokinetics, and activity of GRN1005, a novel conjugate of angiopep-2, a peptide facilitating brain penetration, and paclitaxel, in patients with advanced solid tumorsQ48744788
Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory CancersQ50539670
Use of the neo-adjuvant exemestane in post-menopausal estrogen receptor-positive breast cancer: a randomized phase II trial (PTEX46) to investigate the optimal duration of preoperative endocrine therapy.Q51067697
Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial.Q53158182
Tumor genetic testing for patient selection in phase I clinical trials: the case of PI3K inhibitors.Q53963513
Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes.Q54516956
Adjuvant Capecitabine, Docetaxel, Cyclophosphamide, and Epirubicin for Early Breast Cancer: Final Analysis of the Randomized FinXX TrialQ57278896
Molecular prescreening to select patient population in early clinical trialsQ58614572
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancerQ59289357
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitroQ21195212
Combination anastrozole and fulvestrant in metastatic breast cancerQ24595386
Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitroQ24615499
Comprehensive molecular portraits of human breast tumoursQ24630844
Genome sequencing identifies a basis for everolimus sensitivityQ24631915
Continuous cultures of fused cells secreting antibody of predefined specificityQ26776979
Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancerQ27013852
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriersQ27851474
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancerQ27851691
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trialQ27851705
Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB studyQ27851763
Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Activating ESR1 mutations in hormone-resistant metastatic breast cancerQ27852630
Gene expression profiling predicts clinical outcome of breast cancerQ27860732
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion SequencingQ27860948
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA)Q28291395
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancerQ28372484
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancerQ29614302
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancerQ29620676
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trialQ30080035
Time for more optimism in metastatic breast cancer?Q30354522
Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callersQ30674708
Synthetic lethal screen identification of chemosensitizer loci in cancer cellsQ33281866
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapyQ33321322
Iniparib plus chemotherapy in metastatic triple-negative breast cancerQ33393514
The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trialQ33408750
Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.Q39870542
Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA studyQ40340899
Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.Q40462527
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.Q40529875
Randomized phase III clinical trial designs for targeted agentsQ42165255
Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profilesQ42520469
Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized 'FIRST' studyQ42672762
Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer.Q42882393
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallQ43180234
Sirolimus and temsirolimus for epithelioid angiomyolipomaQ43202687
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancerQ43270036
Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancerQ43279296
Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO studyQ43503861
Hormonal receptor, human epidermal growth factor receptor-2, and Ki67 discordance between primary breast cancer and paired metastases: clinical impactQ43521216
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trialQ43739514
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trialQ44045676
Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trialQ44102213
Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatmentQ44102217
Proliferation of cancer cells despite CDK2 inhibition.Q44391102
Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multQ44699072
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised studyQ44846367
Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trialQ44875574
Metastatic breast cancer: are we treating the same patients as in the past?Q45732407
Reply to M. Gallén et al and R.S. Midgley et al.Q45961601
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancerQ46043819
Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 StudyQ46256397
Humanized antibodies for therapyQ46360542
Model systems: mechanisms involved in the loss of sensitivity to letrozoleQ46557591
Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trialQ46585161
Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT.Q46720989
Phase III trial of sunitinib in combination with capecitabine versus capecitabine monotherapy for the treatment of patients with pretreated metastatic breast cancerQ46757183
Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancerQ33561160
Molecular mechanisms of resistance to tumour anti-angiogenic strategiesQ33718025
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study.Q33827808
Developing safety criteria for introducing new agents into neoadjuvant trialsQ33895825
Similarities and distinctions in the mode of action of different classes of antioestrogensQ33917000
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.Q33964848
Use of neoadjuvant data to design adjuvant endocrine therapy trials for breast cancerQ34174466
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
Role of tyrosine kinase inhibitors in cancer therapyQ34432091
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancersQ34679149
Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patientsQ34996947
Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapyQ35020538
Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-basQ35023441
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implicationsQ35040017
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patientsQ35064705
Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working groupQ35552069
Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancersQ35583968
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.Q35625995
Adjuvant trastuzumab in HER2-positive breast cancerQ35710898
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.Q35737613
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapyQ35842970
Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers--role of estrogen receptor and HER2 reactivationQ35889621
The role of BRCA1 in the cellular response to chemotherapyQ35952250
Redundant cyclin overexpression and gene amplification in breast cancer cellsQ36090819
CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapyQ36130084
Aromatase inhibitors: combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistanceQ36183687
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activationQ36187310
Breast cancer: achievements in adjuvant systemic therapies in the pre-genomic era.Q36395909
Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.Q36494245
Neoadjuvant use of hormonal therapy in elderly patients with early or locally advanced hormone receptor-positive breast cancerQ36655761
Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer.Q36746794
Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006Q36810717
Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriersQ36896061
Fulvestrant (Faslodex) -- how to make a good drug betterQ36900695
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristicsQ36916152
Aromatase inhibition 2013: clinical state of the art and questions that remain to be solvedQ36946008
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancersQ36958682
Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpointsQ37016467
Triple negative tumours: a critical reviewQ37048793
A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancerQ37087832
Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial.Q37095799
Metastatic breast cancer: the role of pegylated liposomal doxorubicin after conventional anthracyclinesQ37116101
Phase III clinical trials that integrate treatment and biomarker evaluationQ37122311
Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trialQ37132369
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistanceQ37240662
Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancerQ37240839
Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges.Q37325013
Trastuzumab combined with pegylated liposomal doxorubicin in patients with metastatic breast cancer. phase II Study of the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation.Q37406658
Drug-diagnostics co-development in oncologyQ37408558
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathwaysQ37425090
Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell linesQ37455274
Final overall survival: fulvestrant 500 mg vs 250 mg in the randomized CONFIRM trialQ37532641
Molecular predictors of response to trastuzumab and lapatinib in breast cancer.Q37660907
Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials.Q37671720
Inducing synthetic lethality using PARP inhibitorsQ37734483
Evolving strategies for overcoming resistance to HER2-directed therapy: targeting the PI3K/Akt/mTOR pathwayQ37813285
Mechanisms of resistance to vascular endothelial growth factor blockadeQ37956587
Enhancing intracellular taxane delivery: current role and perspectives of nanoparticle albumin-bound paclitaxel in the treatment of advanced breast cancerQ37977498
mTOR inhibitors in breast cancer: a systematic reviewQ38042507
Targeted therapy in metastatic colorectal cancer -- an example of personalised medicine in action.Q38078599
A systematic review of trastuzumab and lapatinib in the treatment of women with brain metastases from HER2-positive breast cancerQ38088492
Biopsies: next-generation biospecimens for tailoring therapyQ38116896
Appraising iniparib, the PARP inhibitor that never was--what must we learn?Q38152942
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumorsQ38406496
Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapiesQ38626744
D538G mutation in estrogen receptor-α: A novel mechanism for acquired endocrine resistance in breast cancerQ39064408
Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell linesQ39820639
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)647-668
P577publication date2014-04-23
P1433published inExpert Opinion on Drug DiscoveryQ5421204
P1476titleAdvances in the approach to novel drug clinical development for breast cancer
P478volume9

Reverse relations

cites work (P2860)
Q38840175Adverse event-related costs for systemic metastatic breast cancer treatment among female Medicaid beneficiaries
Q28831422KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL
Q48752979Prodigiosenes conjugated to tamoxifen and estradiol.

Search more.