Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10

scientific article

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10 is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1991PNAS...88.8337K
P356DOI10.1073/PNAS.88.19.8337
P8608Fatcat IDrelease_w6k7adep7rhlvfaag2ahlmihre
P932PMC publication ID52503
P698PubMed publication ID1924293
P5875ResearchGate publication ID21232283

P50authorChristine DistecheQ88355920
P2093author name stringA E Karlsen
F J Grant
D A Adler
S Dube
D Foster
C E Grubin
W A Hagopian
H Bärmeier
S Mathewes
P2860cites workMolecular cloning and amino acid sequence of brain L-glutamate decarboxylaseQ24556603
Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cellsQ24598227
A comprehensive set of sequence analysis programs for the VAXQ26778432
A simple method for displaying the hydropathic character of a proteinQ26778481
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primerQ27860572
Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the MouseQ31095550
Pattern of expression of glutamic acid decarboxylase mRNA in the developing rat brainQ33571925
Developmentally regulated expression of an exon containing a stop codon in the gene for glutamic acid decarboxylaseQ33890475
Characterization of a cDNA coding for rat glutamic acid decarboxylaseQ33943761
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitusQ34172103
gamma-Aminobutyric acid outside the mammalian brainQ34372326
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
Stiff-man syndrome updatedQ34674686
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomasQ37401701
High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human InsulinomaQ40023366
GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.Q41080795
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndromeQ41196484
Evidence for two distinct forms of native glutamic acid decarboxylase in rat brain soluble extract: an immunoblotting studyQ41480565
The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brainQ41956002
Characterization of three kinetically distinct forms of glutamate decarboxylase from pig brainQ41977044
Viable purified islets of Langerhans from collagenase-perfused human pancreasQ42042694
Purification and characterization of glutamate decarboxylase from mouse brainQ42234469
Autoimmunity in stiff man syndromeQ43504795
Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10.Q43995153
Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylaseQ44184394
Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.Q45935043
Chemical and physical properties of Escherichia coli glutamate decarboxylaseQ47781018
Kinetically different, multiple forms of glutamate decarboxylase in rat brainQ48205970
Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion proteinQ48213614
Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5'-phosphate binding site.Q54033619
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteinsQ57449719
Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetesQ61861667
Messenger RNA for myosin polypeptides: isolation from single myogenic cell culturesQ67548624
Effects of sodium butyrate on proliferation-dependent insulin gene expression and insulin release in glucose-sensitive RIN-5AH cellsQ67687949
64,000 Mr autoantibodies as predictors of insulin-dependent diabetesQ68088864
Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigenQ69530151
Crystallization and properties of glutamate decarboxylase from Escherichia coli strain w+Q69826254
Isolation of viable islets of Langerhans from collagenase-perfused canine and human pancreataQ70168098
Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic miceQ93744670
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)8337-8341
P577publication date1991-10-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
P478volume88

Reverse relations

cites work (P2860)
Q33282777A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.
Q52545232A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases.
Q53357215A new solid-phase radioimmunoassay to detect anti-GAD65 autoantibodies.
Q73081435A novel high-throughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies
Q61861656A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM
Q41982714A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region
Q47815857A simple and rapid microSepharose assay for GAD65 and ICA512 autoantibodies in diabetes. Diabetes Incidence Study in Sweden (DISS).
Q48144733Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets
Q50918709Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM.
Q74229022Age of onset, not type of onset, affects the positivity and evanescence of IA-2 antibody
Q22253174Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues
Q36853549An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies
Q50056608Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy.
Q70731822Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2)
Q71788167Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II
Q36954438Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
Q48303867Autoantigenic reactivity of diabetes sera with a hybrid glutamic acid decarboxylase GAD67-65 molecule GAD67(1-101)/GAD65(96-585).
Q40575830Autoantigens in type 1 diabetes mellitus
Q28363451Autoimmune type 1 diabetes: resolved and unresolved issues
Q36202374Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase
Q48499309Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme
Q50972009Calretinin inputs are confined to motoneurons for upward eye movements in monkey.
Q34159440Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
Q57148226Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals
Q36695291Characterization of a linear epitope within the human pancreatic 64‐kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin‐dependent diabetes mellitus patients
Q41005356Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus
Q40416734Circulating Zonulin Correlates with Density of Enteroviruses and Tolerogenic Dendritic Cells in the Small Bowel Mucosa of Celiac Disease Patients
Q37297817Cloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V family
Q45803169Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain
Q44886848Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.
Q45057620Conformation-dependent GAD65 autoantibodies in diabetes
Q37299778Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study.
Q33899197Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression
Q34111857Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase
Q38353381Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM.
Q48391409Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase
Q59649758Enzymatic and structural aspects on glutamate decarboxylase
Q78849136Expression of endocrine autoantibodies in chronic hepatitis C, before and after interferon-alpha therapy
Q61995630Expression of glutamic acid decarboxylase (GAD) in the α, β and δ cells of normal and diabetic pancreas: implications for the pathogenesis of type I diabetes
Q41079519Expression of glutamic acid decarboxylase during human neuronal differentiation: studies using the NTera-2 culture system
Q40575836GAD, diabetes, and Stiff-Man syndrome: some progress and more questions
Q30430711GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus
Q36137876GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).
Q37358994GAD65 autoimmunity-clinical studies.
Q42507827GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.
Q36505520Genes in the GABA Pathway Increase in the Lateral Thalamus of Sprague-Dawley Rats During the Proestrus/Estrus Phase
Q33946742Genetic association analysis of behavioral inhibition using candidate loci from mouse models
Q36361272Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes
Q37255494Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes
Q44879677HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus
Q33848973HLA genes, islet autoantibodies and residual C-peptide at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later
Q36777541HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a
Q35235094High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations
Q70567569Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets
Q36330292Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes
Q28288007ICA69 is expressed equally in the human endocrine and exocrine pancreas
Q41994256Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome
Q35634978Immune intervention yes, but for what reason, for whom, when and how?
Q28087365Immunogenetics of type 1 diabetes mellitus
Q44435975Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).
Q42487438Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies
Q48337407Intra-accumbens infusions of antisense oligodeoxynucleotides to one isoform of glutamic acid decarboxylase mRNA, GAD65, but not to GAD67 mRNA, impairs sustained attention performance in the rat.
Q72429393Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes
Q47706880Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients
Q40569816Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.
Q46115645Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies
Q35824175Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
Q38300551Isolation by anion-exchange of immunologically and enzymatically active human islet glutamic acid decarboxylase 65 overexpressed in Sf9 insect cells
Q43830332Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah
Q36533216Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
Q48393344Molecular biology of IDDM.
Q78059978NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice
Q39774757Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
Q30808583Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase
Q47711606Peptide specificity of high-titer anti-glutamic acid decarboxylase (GAD)65 autoantibodies
Q33907374Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications
Q36117948Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention
Q24307746Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15
Q43924655Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.
Q33902290Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Q36532404Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains
Q41131246Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus
Q24617932Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type
Q34051132Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon
Q40473381Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms
Q54588538Stabilization of recombinantly expressed proteins.
Q57449587T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4
Q42724811TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes
Q40934733The TATA-less rat GAD65 promoter can be activated by Sp1 through non-consensus elements
Q73486424Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
Q24307858Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
Q35934762Type 1 diabetes as a model for prediction and diagnosis
Q35004343Vaccination against type 1 diabetes