Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals

scientific article published on 01 March 2013

Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CEI.12026
P932PMC publication ID3569531
P698PubMed publication ID23379430

P50authorJohnny LudvigssonQ5965102
Christiane S HampeQ44927527
P2093author name stringR Casas
M Chéramy
P2860cites workStiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathiesQ28240917
Stiff person syndromeQ28248173
Autoimmune type 1 diabetes: resolved and unresolved issuesQ28363451
The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acidQ31406782
Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10Q33412441
An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetesQ33873549
Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetesQ33884262
Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxiaQ34162658
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitusQ34172103
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
GAD treatment and insulin secretion in recent-onset type 1 diabetesQ34848774
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1.Q37437161
GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetesQ37520366
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndromeQ41196484
Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.Q41511636
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetesQ44191950
Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trialQ45240370
Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS studyQ45273607
Latent autoimmune diabetes in an adultQ46176878
Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunctionQ46314090
Analysis of GAD65 autoantibodies in Stiff-Person syndrome patientsQ46815045
Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severityQ47311183
Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndromeQ47671744
Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.Q51689887
Stiff-Person SyndromeQ54165707
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.Q55034045
Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodiesQ57449132
GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral responseQ57449133
Screening for prediabetes in the general child population: maternal attitude to participationQ57449474
Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic riskQ62587873
Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognitionQ70844237
IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetesQ77124590
Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65AbsQ79207765
Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetesQ80313062
Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease associationQ80388908
Multiplicity of the antibody response to GAD65 in Type I diabetesQ80892738
Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetesQ81657563
GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistenceQ81661292
Age-related islet autoantibody incidence in offspring of patients with type 1 diabetesQ83363049
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectautoantibodyQ785022
P304page(s)247-254
P577publication date2013-03-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleCharacteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals
P478volume171

Reverse relations

cites work (P2860)
Q37278210Cellular and humoral immune responses in type 1 diabetic patients participating in a phase III GAD-alum intervention trial
Q35746485Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
Q47639572Multiplex family with GAD65-Abs neurologic syndromes
Q38289691Stiff-person syndrome: insights into a complex autoimmune disorder

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