Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial

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Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(15)00366-6
P698PubMed publication ID26590673

P50authorMariusz BidzińskiQ20028388
Isabelle Ray-CoquardQ37995869
Sandro PignataQ56419526
Ignace VergoteQ89808263
Giovanni ScambiaQ91909477
Felix HilpertQ124151001
P2093author name stringWerner Meier
Andreas du Bois
Philipp Harter
Nicoletta Colombo
Alain Lortholary
Susanne Malander
Line Bjørge
Jacobus Pfisterer
Gunnar Kristensen
Alexander Reuss
Mansoor R Mirza
Martin Heubner
Emmanuel Sevin
Maria O Nicoletto
Michael Merger
Petronella Ottevanger
Jose M Del Campo
Nikolaus de Gregorio
Martin Oliver Sailer
Ursula Denison
AGO Study Group led Gynecologic Cancer Intergroup/European Network of Gynaecologic Oncology Trials Groups Intergroup Consortium
Thomas Minarik
P2860cites workTargeting angiogenesis in gynecologic cancersQ26824766
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyQ27650860
Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012Q29615661
Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer IntergroupQ30436714
Exploratory phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer.Q33333839
Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group studyQ33348987
A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancerQ33399785
Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trialQ33413609
Incorporation of pazopanib in maintenance therapy of ovarian cancerQ33417673
A phase 3 trial of bevacizumab in ovarian cancerQ34030022
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activityQ34580980
Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trialQ34658812
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignanciesQ35011280
Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trialQ36287626
Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30.Q37811674
2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus ConferenceQ37872164
Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based studyQ38964573
Advanced Ovarian Cancer: Phase III Randomized Study of Sequential Cisplatin–Topotecan and Carboplatin–Paclitaxel vs Carboplatin–PaclitaxelQ42862031
Phase III Trial of Carboplatin Plus Paclitaxel With or Without Gemcitabine in First-Line Treatment of Epithelial Ovarian CancerQ42928480
Incorporation of bevacizumab in the primary treatment of ovarian cancerQ44579933
Survival for ovarian cancer in Europe: the across-country variation did not shrink in the past decadeQ45891722
Addition of epirubicin as a third drug to carboplatin-paclitaxel in first-line treatment of advanced ovarian cancer: a prospectively randomized gynecologic cancer intergroup trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer SQ46966646
Small sample inference for fixed effects from restricted maximum likelihood.Q52255259
Randomized phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a gynecologic cancer intergroup trial of the AGO-OVAR and GINECO.Q53251965
A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer.Q53298171
Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer.Q54566293
Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe OvarialQ83287534
Bevacizumab in the treatment of ovarian cancerQ84919012
Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ86063198
P433issue1
P921main subjectchemotherapyQ974135
ovarian cancerQ172341
placeboQ269829
phase III clinical trialQ42824827
P304page(s)78-89
P577publication date2015-11-13
P1433published inLancet Oncology CommissionQ13747613
P1476titleStandard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial
P478volume17

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cites work (P2860)
Q50080825A synthetic lethal bullet
Q48104995Advances in ovarian cancer therapy
Q55217694Angiogenesis Inhibitors for the Treatment of Ovarian Cancer: An Updated Systematic Review and Meta-analysis of Randomized Controlled Trials.
Q38872239Anti-angiogenic agents in ovarian cancer: past, present, and future.
Q58706801Antiangiogenesis therapy in ovarian cancer patients: An updated meta-analysis for 15 randomized controlled trials
Q28073722Antiangiogenic therapies in ovarian cancer
Q92548235Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer: A Systematic Review and Meta-analysis
Q38822258Bevacizumab and paclitaxel-carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial
Q92035335Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial
Q98158111Bevacizumab plus fosbretabulin in recurrent ovarian cancer: Overall survival and exploratory analyses of a randomized phase II NRG oncology/gynecologic oncology group study
Q57456582Cardiovascular Toxicities with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Meta-Analysis of 77 Randomized Controlled Trials
Q37094042Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients
Q90736221Comparing Paclitaxel-Carboplatin with Paclitaxel-Cisplatin as the Front-Line Chemotherapy for Patients with FIGO IIIC Serous-Type Tubo-Ovarian Cancer
Q93355703Early tumor regrowth is a contributor to impaired survival in patients with completely resected advanced ovarian cancer. An exploratory analysis of the Intergroup trial AGO-OVAR 12
Q90322004Epidermal growth factor receptor/heme oxygenase-1 axis is involved in chemoresistance to cisplatin and pirarubicin in HepG2 cell lines and hepatoblastoma specimens
Q38874036FIGO stage IV epithelial ovarian, fallopian tube and peritoneal cancer revisited
Q52584387First-line treatment of ovarian cancer: questions and controversies to address.
Q37512962Focus on Nintedanib in NSCLC and Other Tumors
Q49895978Front-line therapy of advanced epithelial ovarian cancer: standard treatment
Q47323988Front-line therapy of advanced ovarian cancer: new approaches
Q92906903Immune Heterogeneity Between Primary Tumors and Corresponding Metastatic Lesions and Response to Platinum Therapy in Primary Ovarian Cancer
Q33563488Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib
Q65000120Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review.
Q28077183Major clinical research advances in gynecologic cancer in 2015
Q33563963Major clinical research advances in gynecologic cancer in 2016: 10-year special edition
Q26741755Management of relapsed ovarian cancer: a review
Q94046968MicroRNAs as Key Regulators of Ovarian Cancers
Q64121576Molecular Characterization of Non-responders to Chemotherapy in Serous Ovarian Cancer
Q42347314Negative trials in ovarian cancer: is there such a thing as too much optimism?
Q92618072Neurofibromin 1 expression is negatively correlated with malignancy and prognosis of epithelial ovarian cancer
Q90237649Nintedanib for the treatment of patients with refractory metastatic colorectal cancer (LUME-Colon 1): a phase III, international, randomized, placebo-controlled study
Q51824301Nintedanib in ovarian cancer.
Q64284104Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition
Q88195269Ovarian cancer
Q90098861Overall survival results of AGO-OVAR16: A phase 3 study of maintenance pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced ovarian cancer
Q92567882Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway
Q90029904Patient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials
Q37544401Phase I study of nintedanib in Japanese patients with advanced hepatocellular carcinoma and liver impairment
Q92726174Phase II trial of nintedanib in patients with bevacizumab-resistant recurrent epithelial ovarian, tubal, and peritoneal cancer
Q30249619Risk of selected gastrointestinal and hepatic toxicities in cancer patients treated with nintedanib: a meta-analysis.
Q47719824Safety and efficacy of nintedanib for the treatment of metastatic colorectal cancer
Q33885479Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study
Q31125419Same Data; Different Interpretations
Q56957787Sorafenib plus topotecan versus placebo plus topotecan for platinum-resistant ovarian cancer (TRIAS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Q47370432Synthetically lethal nanoparticles for treatment of endometrial cancer.
Q47685928Targeted Therapies in the Management of Ovarian Cancer: A Focus on Older Patients
Q38760610Targeted agents and combinations in ovarian cancer: where are we now?
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q58789499Targeting the Microenvironment in High Grade Serous Ovarian Cancer
Q41619260Thalidomide and lenalidomide for recurrent ovarian cancer: A systematic review of the literature
Q49966031The role of Cediranib in ovarian cancer
Q52645823The role of tumor microenvironment in resistance to anti-angiogenic therapy.
Q61818032Therapeutic advances in hormone-dependent cancers: focus on prostate, breast and ovarian cancers
Q50042447Therapeutic impact of nanoparticle therapy targeting tumor-associated macrophages
Q64109213Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial
Q98771756Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy
Q90342385Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer
Q91645432Weekly Dose-Dense Paclitaxel and Triweekly Low-Dose Cisplatin: A Well-Tolerated and Effective Chemotherapeutic Regimen for First-Line Treatment of Advanced Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

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