Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer.

scientific article

Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2010.33.5208
P698PubMed publication ID21859991

P50authorHani GabraQ5648162
Gordon C. JaysonQ37839060
Timothy PerrenQ43194270
Iain A McNeishQ55130375
Helena EarlQ55477671
P2093author name stringMartin Gore
Malcolm Adams
Allan Hackshaw
Jonathan A Ledermann
Graham Temple
Stan Kaye
Michael Merger
Gordon Rustin
Mojca Persic
Lindsay James
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
placeboQ269829
chemotherapyQ974135
phase II clinical trialQ42824440
placebo-controlled trialQ108853737
P304page(s)3798-3804
P577publication date2011-08-22
P1433published inJournal of Clinical OncologyQ400292
P1476titleRandomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
P478volume29

Reverse relations

cites work (P2860)
Q89057719A Phase I/Randomized Phase II Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Nintedanib versus Sorafenib in Asian Patients with Advanced Hepatocellular Carcinoma
Q43902249A phase 2 study of cediranib in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: a trial of the Princess Margaret, Chicago and California Phase II Consortia
Q100736351A phase II randomised, placebo-controlled trial of low dose (metronomic) cyclophosphamide and nintedanib (BIBF1120) in advanced ovarian, fallopian tube or primary peritoneal cancer
Q52628568A phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinoma.
Q38553247An overview of early investigational therapies for chemoresistant ovarian cancer.
Q38631373An overview of tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer.
Q55217694Angiogenesis Inhibitors for the Treatment of Ovarian Cancer: An Updated Systematic Review and Meta-analysis of Randomized Controlled Trials.
Q38130312Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales
Q38115596Anti-angiogenic drugs currently in Phase II clinical trials for gynecological cancer treatment
Q35205410Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches.
Q58706801Antiangiogenesis therapy in ovarian cancer patients: An updated meta-analysis for 15 randomized controlled trials
Q37661852Antiangiogenic drugs used with chemotherapy for patients with recurrent ovarian cancer: a meta-analysis
Q33662162Bevacizumab in combination with chemotherapy for the treatment of advanced ovarian cancer: a systematic review
Q26779120Beyond Bevacizumab: An Outlook to New Anti-Angiogenics for the Treatment of Ovarian Cancer
Q38151193Beyond bevacizumab: investigating new angiogenesis inhibitors in ovarian cancer
Q27024235Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer
Q37937858Clinical trials and decision-making strategies for optimal treatment of relapsed ovarian cancer
Q38286128Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy
Q43657215Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study
Q36855239Epithelial ovarian cancer: the molecular genetics of epithelial ovarian cancer
Q90133145Expression of FGFR1-4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity
Q37981986FGF receptor inhibitors: role in cancer therapy
Q37462489FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib.
Q38213500First-line and maintenance therapy for ovarian cancer: current status and future directions
Q37512962Focus on Nintedanib in NSCLC and Other Tumors
Q38123207Genetic changes in nonepithelial ovarian cancer
Q33598883Identification of target genes of cediranib in alveolar soft part sarcoma using a gene microarray
Q38169470Incorporation of anti-angiogenesis therapy in the management of advanced ovarian carcinoma--mechanistics, review of phase III randomized clinical trials, and regulatory implications
Q33563488Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib
Q92451281Inhibitory effect of nintedanib on VEGF secretion in retinal pigment epithelial cells induced by exposure to a necrotic cell lysate
Q33920800Investigational agents in development for the treatment of ovarian cancer
Q38340008Investigational therapies currently in Phase II clinical trials for the treatment of pelvic serous carcinomas.
Q90231859Kinase Inhibitors and Ovarian Cancer
Q65000120Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review.
Q26781561Maintenance Therapy in Ovarian Cancer with Targeted Agents Improves PFS and OS: A Systematic Review and Meta-Analysis
Q38222277Maintenance therapy in epithelial ovarian cancer: from chemotherapy to targeted agents
Q93059467Medication persistence rates and predictive factors for discontinuation of antifibrotic agents in patients with idiopathic pulmonary fibrosis: a real-world observational study
Q42347314Negative trials in ovarian cancer: is there such a thing as too much optimism?
Q38175506New biological treatments for gynecological tumors: focus on angiogenesis
Q28082524New perspectives on targeted therapy in ovarian cancer
Q51824301Nintedanib in ovarian cancer.
Q64284104Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition
Q35670576Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.
Q38430583Nintedanib: A Review of Its Use as Second-Line Treatment in Adults with Advanced Non-Small Cell Lung Cancer of Adenocarcinoma Histology
Q54307476Nintedanib: first global approval.
Q47424260Novel antiangiogenic therapies in ovarian cancer
Q38198095Novel therapies, including enzastaurin, in the treatment of ovarian cancer
Q38654552Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial
Q26777846Ovarian Cancer Molecular Stratification and Tumor Heterogeneity: A Necessity and a Challenge
Q54105461Ovarian cancer
Q38040628Ovarian cancer: advances in first-line treatment strategies with a particular focus on anti-angiogenic agents.
Q37332480Ovarian cancer: genomic analysis.
Q38180762PARP inhibitors for anticancer therapy
Q35602123Paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer: a randomized phase II study of the Sarah Cannon Research Institute
Q36648394Palliative systemic therapy for women with recurrent epithelial ovarian cancer: current options
Q26777928Pharmacological treatment of idiopathic pulmonary fibrosis - preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine
Q64237473Phase 1b trial of nintedanib in combination with bevacizumab in patients with advanced solid tumors
Q35678397Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study).
Q35623311Phase I study of BIBF 1120 with docetaxel and prednisone in metastatic chemo-naive hormone-refractory prostate cancer patients.
Q41130079Phase I study of nintedanib in combination with pemetrexed as second-line treatment of Japanese patients with advanced non-small cell lung cancer
Q35739542Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours
Q43989660Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme
Q37996468Potential dual role of KGF/KGFR as a target option in novel therapeutic strategies for the treatment of cancers and mucosal damages
Q36730777Prediction of anti-angiogenesis escape
Q47664784Prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell carcinomas of the head and neck
Q26751280Profile of bevacizumab in the treatment of platinum-resistant ovarian cancer: current perspectives
Q26775134Profile of nintedanib in the treatment of solid tumors: the evidence to date
Q37390113Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation.
Q51795514Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer.
Q36957621Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib
Q37495153Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.
Q27016629Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
Q30249619Risk of selected gastrointestinal and hepatic toxicities in cancer patients treated with nintedanib: a meta-analysis.
Q47719824Safety and efficacy of nintedanib for the treatment of metastatic colorectal cancer
Q83840457Sequential bevacizumab and oral cyclophosphamide for recurrent ovarian cancer
Q33427744Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial
Q38760610Targeted agents and combinations in ovarian cancer: where are we now?
Q26750649Targeted agents in epithelial ovarian cancer: review on emerging therapies and future developments
Q26830287Targeted anti-vascular therapies for ovarian cancer: current evidence
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q95383069Targeted therapies: Congratulations, you are still in the running towards becoming ovarian-next-top treatment
Q37988981Targeted therapy in head and neck cancer
Q26824766Targeting angiogenesis in gynecologic cancers
Q58789499Targeting the Microenvironment in High Grade Serous Ovarian Cancer
Q36626921Targeting the tumour microenvironment in ovarian cancer
Q38118388Targeting tyrosine-kinases in ovarian cancer
Q27698320The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition
Q30248645The Emerging Role of Tyrosine Kinase Inhibitors in Ovarian Cancer Treatment: A Systematic Review
Q38144166The potential of sunitinib as a therapy in ovarian cancer
Q35920527The prognostic significance of anti-angiogenesis therapy in ovarian cancer: a meta-analysis
Q39393740Tumor angiogenesis revisited: Regulators and clinical implications.
Q36571743Update on first-line treatment of advanced ovarian carcinoma
Q36929772Updates on drug discovery in ovarian cancer
Q33926377Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis

Search more.