siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells

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siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1052034106
P356DOI10.1186/1471-2407-9-133
P932PMC publication ID2691745
P698PubMed publication ID19416503
P5875ResearchGate publication ID24402720

P2093author name stringLi Zhong
Anding Liu
Xuejun Dong
Jianguo Feng
Mingfeng Yang
Cindy Zer
Zhuan Zhen
P2860cites workTelomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cellsQ40258967
Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin.Q40393833
Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapyQ40401433
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomeraseQ40812288
Anthracyclines in the treatment of cancer. An overviewQ41637134
Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunctionQ44052589
Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach.Q44302040
hTERT mRNA expression correlates with telomerase activity in human breast cancerQ44414127
RNAi-hTERT inhibition hepatocellular carcinoma cell proliferation via decreasing telomerase activityQ45888719
Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effectQ46679847
Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairmentQ60589813
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase IIQ64390546
TERT regulates cell survival independent of telomerase enzymatic activityQ74355604
hTERT associates with human telomeres and enhances genomic stability and DNA repairQ78794137
Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growthQ80129040
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Mechanisms of gene silencing by double-stranded RNAQ28282560
A highly selective telomerase inhibitor limiting human cancer cell proliferationQ29301431
Dose-dense therapy in the treatment of early-stage breast cancer: an overview of the dataQ31146991
The role of telomerase in breast cancerQ34052043
A systematic overview of chemotherapy effects in breast cancerQ34301214
Telomeres and telomerase: their mechanisms of action and the effects of altering their functionsQ34389435
Small interfering RNA for experimental cancer therapy.Q34412952
RNA interference: mechanisms and applicationsQ34423362
Telomerase and cancer stem cellsQ34569385
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cellsQ34625589
Overview of resistance to systemic therapy in patients with breast cancerQ34712197
Liposomal anthracyclines for breast cancer: overviewQ35297379
Targeting telomerase by antisense-based approaches: perspectives for new anti-cancer therapies.Q36107375
Telomerase and its potential for therapeutic interventionQ36171337
Telomeres and telomerase: Pharmacological targets for new anticancer strategies?Q36418055
Advances in the treatment of breast cancerQ37037373
Delivery vehicles for small interfering RNA in vivoQ37079140
Nanotechnology for breast cancer therapyQ37229262
Targeted therapies in breast cancer: established drugs and recent developmentsQ37239225
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.Q38291849
Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activityQ38331538
Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cellsQ38350135
Growth stimulation leads to cellular senescence when the cell cycle is blockedQ39925937
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiationQ39957013
Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancerQ40209779
Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA.Q40223962
Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cellsQ40246796
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
P304page(s)133
P577publication date2009-05-05
P1433published inBMC CancerQ326300
P1476titlesiRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells
P478volume9

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cites work (P2860)
Q38881802A combination of the telomerase inhibitor, BIBR1532, and paclitaxel synergistically inhibit cell proliferation in breast cancer cell lines
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Q90576953HKR3 regulates cell cycle through the inhibition of hTERT in hepatocellular carcinoma cell lines
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Q39030709Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery
Q36275036Knockdown of hTERT and Treatment with BIBR1532 Inhibit Cell Proliferation and Invasion in Endometrial Cancer Cells
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