Therapeutic Targets in Telomerase and Telomere Biology of Cancers

scientific article published on 10 March 2020

Therapeutic Targets in Telomerase and Telomere Biology of Cancers is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S12291-020-00876-8
P932PMC publication ID7093628
P698PubMed publication ID32226245

P2093author name stringRajendra Prasad
Deeksha Pal
Wajid Mohammad
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivoQ24305098
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinQ24310658
Telomere protection by mammalian Pot1 requires interaction with Tpp1Q24319841
Control of telomere length by the human telomeric protein TRF1Q24320111
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexesQ24336203
POT1 and TRF2 cooperate to maintain telomeric integrityQ24338505
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Control of human telomere length by TRF1 and TRF2Q24554302
RNA interference: biology, mechanism, and applicationsQ24597695
TERRA: telomeric repeat-containing RNAQ24656014
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapiesQ26744271
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic MechanismsQ26744572
An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalizationQ28116246
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptaseQ28138478
Secondary structure of vertebrate telomerase RNAQ28138961
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytesQ28139460
The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cellsQ45713501
The Genetic Evolution of Melanoma from Precursor LesionsQ46079642
Inhibition of hTERT expression by MAP kinase inhibitor induces cell death in renal cell carcinoma.Q50884246
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.Q51598430
Augmented telomerase activity, reduced telomere length and the presence of alternative lengthening of telomere in renal cell carcinoma: plausible predictive and diagnostic markers.Q53584574
TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA.Q54347306
Nano-Strategies to Fight Multidrug Resistant Bacteria-"A Battle of the Titans"Q57177419
Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytiQ58380161
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell linesQ73851376
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) bodyQ78257210
Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancerQ81482708
Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemiaQ83230375
Cancer vaccination with telomerase peptide GV1001Q83709515
Expression and clinical significance of COMPASS family of histone methyltransferases in clear cell renal cell carcinomaQ89260124
Telomere Loop Dynamics in Chromosome End ProtectionQ90393979
A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solutionQ91323666
Reduction in H3K4me patterns due to aberrant expression of methyltransferases and demethylases in renal cell carcinoma: prognostic and therapeutic implicationsQ92502665
Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomeraseQ40174226
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cellsQ40503963
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibitionQ40554439
Telomere maintenance by recombination in human cells.Q40839283
Regulation mechanisms of mammalian telomerase. A review.Q41703149
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.Q42057695
Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinomaQ42444688
TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation.Q42456732
Highly prevalent TERT promoter mutations in bladder cancer and glioblastomaQ43128951
How shelterin solves the telomere end-protection problemQ44220453
A conserved WD40 protein binds the Cajal body localization signal of scaRNP particlesQ28238122
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoterQ28293716
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formationQ28854371
The Fusion of Broken Ends of Chromosomes Following Nuclear FusionQ28913702
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
Highly recurrent TERT promoter mutations in human melanomaQ29614798
TERT promoter mutations in familial and sporadic melanomaQ29614920
Structure and function of telomeresQ29615759
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
Gene silencing in cancer in association with promoter hypermethylationQ29617274
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Mutation in TERT separates processivity from anchor-site functionQ30446605
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeresQ33250127
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.Q33293671
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectQ33302426
siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cellsQ33439232
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas.Q33737472
Molecular mechanisms of action of antisense drugsQ33916100
Functional multimerization of the human telomerase reverse transcriptaseQ33969441
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.Q34012344
The biogenesis and regulation of telomerase holoenzymesQ34042917
A physical and functional constituent of telomerase anchor siteQ34049648
Alternative lengthening of telomeres in mammalian cellsQ34114656
InTERTpreting telomerase structure and functionQ34146318
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signalingQ34518947
The structure and function of telomerase reverse transcriptaseQ34535163
Telomerase as a universal tumor-associated antigen for cancer immunotherapyQ34535727
Telomerase RNA structure and function: implications for dyskeratosis congenita.Q34547087
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeresQ34604352
TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinomaQ34654382
Telomere length, stem cells and agingQ34689235
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.Q34729916
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activityQ34785876
Corruption of the intra-gene DNA methylation architecture is a hallmark of cancerQ34847813
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.Q35041364
Ku acts in a unique way at the mammalian telomere to prevent end joiningQ35207184
Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.Q35676663
A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERTQ35751775
The peptide nucleic acids (PNAs), powerful tools for molecular genetics and cytogeneticsQ35814990
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damageQ35904248
TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas.Q36413047
Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomereQ36451842
Highlights in experimental therapeuticsQ36463460
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanismQ36610311
Telomerase inhibition in cancer therapeutics: molecular-based approachesQ36638624
Prospects and challenges of building a cancer vaccine targeting telomeraseQ36918394
Physiological assembly and activity of human telomerase complexesQ37022486
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesionsQ37064910
Strategies targeting telomerase inhibitionQ37067685
Telomerase and cancer therapeuticsQ37078833
Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeresQ37112118
Defining the molecular mechanisms of human cell immortalizationQ37173111
Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinomaQ37225274
TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urineQ37663771
Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.Q37825614
Novel anticancer therapeutics targeting telomeraseQ38030204
Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.Q38348979
Replicating through telomeres: a means to an end.Q38549970
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanismQ38619216
hTERT knockdown in human embryonic kidney cells using double-stranded RNAQ39025568
RNA interference using a plasmid construct expressing short-hairpin RNAQ39025712
Frequency of TERT promoter mutations in human cancersQ39120274
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q lossQ39139952
Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.Q39291071
Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunitQ39677546
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivityQ39792077
Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell linesQ39998080
P433issue2
P304page(s)135-146
P577publication date2020-03-10
P1433published inIndian journal of clinical biochemistryQ26853918
P1476titleTherapeutic Targets in Telomerase and Telomere Biology of Cancers
P478volume35

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