| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1016/0304-419X(91)90003-4 |
| P953 | full work available at URL | https://api.elsevier.com/content/article/PII:0304419X91900034?httpAccept=text/plain |
| https://api.elsevier.com/content/article/PII:0304419X91900034?httpAccept=text/xml | ||
| P698 | PubMed publication ID | 1850299 |
| P2093 | author name string | H. Werbin | |
| J. W. Shay | |||
| W. E. Wright | |||
| P2860 | cites work | Cancer Research | Q326097 |
| Biochimica et Biophysica Acta | Q864239 | ||
| Developmental Biology | Q3025402 | ||
| Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas | Q28269089 | ||
| Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein | Q29541648 | ||
| Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line | Q29547520 | ||
| Characteristics of a human cell line transformed by DNA from human adenovirus type 5 | Q29547863 | ||
| The p53 proto-oncogene can act as a suppressor of transformation | Q34440370 | ||
| p53: oncogene or anti-oncogene? | Q34627381 | ||
| Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts | Q36770102 | ||
| Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent | Q36770140 | ||
| Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer | Q37920648 | ||
| An intricate route to immortality | Q38267805 | ||
| Characterization of human cells transformed by chemical and physical carcinogens in vitro | Q38481881 | ||
| Towards an understanding of the malignant transformation of diploid human fibroblasts | Q39643129 | ||
| Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen | Q41272620 | ||
| Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells | Q41407134 | ||
| Induction of cellular senescence in immortalized cells by human chromosome 1. | Q41744236 | ||
| Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1). | Q42808779 | ||
| Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells | Q43693588 | ||
| Human retinoblastoma susceptibility gene: cloning, identification, and sequence | Q48348004 | ||
| Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. | Q53436940 | ||
| Random integration of SV40 in SV40-transformed, immortalized human fibroblasts. | Q53531339 | ||
| Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. | Q53575628 | ||
| X-ray induced in vitro neoplastic transformation of human diploid cells. | Q53578188 | ||
| The cancer problem | Q67332134 | ||
| Evidence for the recessive nature of cellular immortality | Q71810575 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | genetics | Q7162 |
| oncology | Q162555 | ||
| dysplasia | Q1128996 | ||
| P304 | page(s) | 1-7 | |
| P577 | publication date | 1991-04-01 | |
| 1991-04-16 | |||
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Defining the molecular mechanisms of human cell immortalization | |
| P478 | volume | 1072 |
| Q24562644 | A biomarker that identifies senescent human cells in culture and in aging skin in vivo |
| Q42325498 | A critical role for TORC1 in cellular senescence |
| Q60920444 | A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration |
| Q38847003 | Air Pollution Stress and the Aging Phenotype: The Telomere Connection. |
| Q24548323 | Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates |
| Q72224591 | Alteration in the retinoblastoma gene associated with immortalization of human fibroblasts treated with 60Co gamma rays |
| Q35010156 | An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer |
| Q55262646 | Anti-inflammatory, antiproliferative and cytoprotective potential of the Attalea phalerata Mart. ex Spreng. pulp oil. |
| Q46246683 | Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy |
| Q38941719 | Bone regeneration in the stem cell era: safe play for the patient? |
| Q52832311 | Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. |
| Q24302257 | CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms |
| Q49752790 | CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs). |
| Q36070936 | Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells |
| Q43619522 | Cell proliferation and cell death in immunosenescence |
| Q26767454 | Cellular Senescence as the Causal Nexus of Aging |
| Q29615561 | Cellular senescence: when bad things happen to good cells |
| Q40670991 | Characterisation of telomerase immortalised normal human oesophageal squamous cells |
| Q41517923 | Characterization of immortalized mouse granulosa cell lines |
| Q90167016 | Chromothripsis and telomere crisis: engines of genome instability |
| Q34624008 | Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. |
| Q38844951 | Conditional immortalization of primary adipocyte precursor cells |
| Q42386180 | Dancing around the fountain |
| Q41348520 | Derivation of phenobarbital-responsive immortal rat hepatocytes. |
| Q36754020 | Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization |
| Q92664567 | Diverse regulatory manners of human telomerase reverse transcriptase |
| Q73348974 | Effects of epidermal growth factor on growth of cell lines established from cynomolgus monkey hepatocytes with SV40 T antigen |
| Q34117528 | Enumeration of the simian virus 40 early region elements necessary for human cell transformation |
| Q34043029 | Establishment of Hertwig's epithelial root sheath/epithelial rests of Malassez cell line from human periodontium |
| Q36614811 | Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability |
| Q24646710 | Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor |
| Q38775625 | Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve |
| Q40442293 | Genetic instability as a consequence of inappropriate entry into and progression through S-phase. |
| Q33296078 | Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells |
| Q35096589 | High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. |
| Q28363408 | Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model |
| Q53449725 | Immortal, non-tumourigenic mouse mammary outgrowths express high levels of cyclin B1 and activation of cyclin B1/cdc2 kinase. |
| Q53481721 | Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism. |
| Q41086139 | Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays |
| Q41431649 | Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts |
| Q42937079 | Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei. |
| Q34943419 | Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine |
| Q46249474 | Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD). |
| Q34334869 | Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence |
| Q35536378 | Mammary transplantation of stromal cells and carcinoma cells in C57BL/6J mice |
| Q46265960 | Management and potentialities of primary cancer cultures in preclinical and translational studies |
| Q52727349 | Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer. |
| Q38117056 | Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research |
| Q39443289 | Mimicking Parkinson's Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models. |
| Q33641924 | Modeling platinum sensitive and resistant high-grade serous ovarian cancer: development and applications of experimental systems |
| Q40395982 | Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity |
| Q45788142 | Modulation of cell phenotype in human osteoblast‐like cells by the simian virus 40 |
| Q39579228 | Molecular pathogenesis of aging and cancer: are telomeres and telomerase the connection? |
| Q28298841 | Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins |
| Q24294537 | Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts |
| Q38864072 | New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression |
| Q47099795 | Non-invasive in vivo molecular imaging of intra-articularly transplanted immortalized bone marrow stem cells for osteoarthritis treatment |
| Q36837394 | Nuclear Factor κB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels. |
| Q40159365 | Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function |
| Q37410396 | One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation. |
| Q42496436 | Overexpression of human telomerase RNA in Helicobacter pylori-infected human gastric mucosa |
| Q36733395 | Oxidative stress under ambient and physiological oxygen tension in tissue culture |
| Q73261555 | Performance characteristics of multiple urinary tumor markers and sample collection techniques in the detection of transitional cell carcinoma of the bladder |
| Q58699214 | Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer |
| Q33761453 | Phenotypic and in vivo functional characterization of immortalized human fetal liver cells |
| Q41492396 | Polybrene/DMSO-assisted gene transfer. Generating stable transfectants with nanogram amounts of DNA. |
| Q73875826 | Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas |
| Q36645358 | Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells |
| Q41181305 | Reversal of the temperature-shift-induced growth restriction of a temperature-sensitive simian virus 40 T-antigen-transformed human fibroblast cell line by treatment with retinoic acid |
| Q36971261 | Role of Telomeres and Telomerase in Aging and Cancer |
| Q35125971 | Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer |
| Q34633162 | Role of telomeres and telomerase in cancer |
| Q72254153 | SV40 large T antigen immortalization of human articular chondrocytes |
| Q35659514 | Senescence, immortalization, and apoptosis. An intriguing relationship |
| Q33997986 | Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci |
| Q36567058 | Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome |
| Q36633820 | Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes |
| Q30412102 | Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. |
| Q39805000 | Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells |
| Q22010863 | TIN2, a new regulator of telomere length in human cells |
| Q37202523 | Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes |
| Q35142569 | Telomerase activity in human ovarian carcinoma |
| Q47805523 | Telomerase activity in pituitary adenomas: significance of telomerase expression in predicting pituitary adenoma recurrence |
| Q39444785 | Telomerase activity is sufficient to allow transformed cells to escape from crisis |
| Q42382632 | Telomere Restriction Fragment (TRF) Analysis |
| Q41135708 | Telomere function in colorectal cancer. |
| Q34731430 | Telomere length modulation in human astroglial brain tumors |
| Q36017636 | Telomeres and telomerase in normal and cancer stem cells |
| Q36363871 | The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes |
| Q33889383 | The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. |
| Q41739824 | The genetics of cellular senescence |
| Q36104924 | The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy |
| Q90744618 | Therapeutic Targets in Telomerase and Telomere Biology of Cancers |
| Q40920562 | Toward a molecular understanding of human breast cancer: a hypothesis |
| Q35354212 | Ubiquitin-independent proteasomal degradation during oncogenic viral infections |
| Q40798787 | Why are human cells resistant to malignant cell transformation in vitro? |
| Q37287025 | Wnt-signaling and senescence: A tug of war in early neoplasia? |
| Q34614831 | hTERT extends the life of human fibroblasts without compromising type I interferon signaling. |
| Q33962054 | mTOR Signaling from Cellular Senescence to Organismal Aging |
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