Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

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Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism is …
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scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.AAO0535
P932PMC publication ID5942222
P698PubMed publication ID28818973

P50authorXavier DarzacqQ37615063
Dirk HockemeyerQ37615665
Boris C. BastianQ41044834
Franziska K LorbeerQ60683418
David Trombley McSwiggenQ83226212
Alan ShainQ89499155
Kunitoshi ChibaQ96187336
Areum OhQ96187337
Jekwan RyuQ96187338
P2093author name stringEva Schruf
P2860cites workPOT1 as a terminal transducer of TRF1 telomere length controlQ24302841
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapiesQ26744271
The short and long telomere syndromes: paired paradigms for molecular medicineQ26800388
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Pot1, the putative telomere end-binding protein in fission yeast and humansQ28188476
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factorsQ28749672
Highly recurrent TERT promoter mutations in human melanomaQ29614798
TERT promoter mutations in familial and sporadic melanomaQ29614920
Genetic engineering of human pluripotent cells using TALE nucleasesQ29619830
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleasesQ29622846
Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancerQ30459452
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endQ33217702
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in miceQ33914498
The effect on melanoma risk of genes previously associated with telomere lengthQ34333988
Genomic Classification of Cutaneous MelanomaQ34670776
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificityQ34687302
Shorter telomeres associate with a reduced risk of melanoma developmentQ35501952
Cancer-associated TERT promoter mutations abrogate telomerase silencingQ35866376
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plusQ35969867
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewalQ36762656
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancerQ36897003
A prospective study of telomere length and the risk of skin cancerQ37076026
Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In VivoQ37595167
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse GliomaQ38453759
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Q38874534
Telomeres in cancer: tumour suppression and genome instabilityQ39016011
Whole-genome landscapes of major melanoma subtypes.Q39060449
TERT promoter mutations in melanoma survivalQ39998496
The nature of telomere fusion and a definition of the critical telomere length in human cellsQ40073766
TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin InteractionsQ42748231
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.Q42814127
The Genetic Evolution of Melanoma from Precursor LesionsQ46079642
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranesQ48878018
Long telomeres and cancer risk among 95 568 individuals from the general population.Q52855805
Telomere dysfunction and the initiation of genome instability.Q55036686
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage diseaseQ61936421
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatomaQ80299557
Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengthsQ82491708
P433issue6358
P407language of work or nameEnglishQ1860
P304page(s)1416-1420
P577publication date2017-08-17
P1433published inScienceQ192864
P1476titleMutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism
P478volume357

Reverse relations

cites work (P2860)
Q89893294Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends
Q89664688Androgen receptor-binding sites are highly mutated in prostate cancer
Q90664270CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Q112724548Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
Q94687033Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma
Q57797239Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behaviour of bladder cancer
Q57787252DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
Q92887487Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes
Q91385901Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
Q49545769Dynamics of human telomerase recruitment depend on template- telomere base pairing
Q50054621Dysfunctional telomeres and hematological disorders.
Q55495686ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma.
Q47224965ETS1, nucleolar and non-nucleolar TERT expression in nevus to melanoma progression
Q90719450Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults
Q88476212Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
Q90128325Genome rearrangements associated with aberrant telomere maintenance
Q61805743Identification of genes involved in the regulation of TERT in hepatocellular carcinoma
Q97542867Identification of shared genomic aberrations between angiomatous and microcystic meningiomas
Q89777623Maintenance of telomere length in AML
Q52727349Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer.
Q91723523Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players
Q47227422Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells
Q52343716Molecular genomic landscapes of hepatobiliary cancer.
Q52725991Montagna Symposium 2017-Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment.
Q58595545New generation cancer therapy: right direction for sure with some uncertainty
Q57457238Novel immune signatures associated with dysplastic nevi and primary cutaneous melanoma in human skin
Q92564137PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription
Q90318108Pathogenic TERT promoter variants in telomere diseases
Q52608306Reconstructing the molecular life history of gliomas.
Q91884598Recurrent Noncoding Mutations in Skin Cancers: UV Damage Susceptibility or Repair Inhibition as Primary Driver?
Q91522991Regulation of human telomerase in homeostasis and disease
Q64243404Revisiting Telomere Shortening in Cancer
Q59332881SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations
Q55465529Short- and long-term evolution in our arms race with cancer: Why the war on cancer is winnable.
Q98771221TERT Promoter Mutation C228T Increases Risk for Tumor Recurrence and Death in Head and Neck Cancer Patients
Q49957857TERT promoter mutation in adult granulosa cell tumor of the ovary.
Q64114386TERT promoter mutations in melanoma survival
Q90749197TERT, a promoter of CNS malignancies
Q98177214Targeting telomerase for cancer therapy
Q64055352Targeting the ERK Signaling Pathway in Melanoma
Q90211132Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics
Q55443450Telomere Maintenance Mechanisms in Cancer.
Q96224238Telomere dysfunction activates p53 and represses HNF4α expression leading to impaired human hepatocyte development and function
Q90351399Telomere length and survival in primary cutaneous melanoma patients
Q91379882Telomere length, telomerase reverse transcriptase promoter mutations, and melanoma risk
Q52714796Telomere sequence content can be used to determine ALT activity in tumours.
Q89976278Telomeres and Telomere Length: A General Overview
Q90682184The Mutational Landscape of Pancreatic and Liver Cancers, as Represented by Circulating Tumor DNA
Q90596932The Solo Play of TERT Promoter Mutations
Q89470187The TERT promoter mutation status and MGMT promoter methylation status, combined with dichotomized MRI-derived and clinical features, predict adult primary glioblastoma survival
Q59332936The ins and outs of telomere crisis in cancer
Q90145180The prognostic significance of TERT promoter mutations in meningioma: a systematic review and meta-analysis
Q93117015The role of telomeres and telomerase in cirrhosis and liver cancer
Q90744618Therapeutic Targets in Telomerase and Telomere Biology of Cancers
Q90917856Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation
Q52662392When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.