Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere

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Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.415984
P932PMC publication ID3516710
P698PubMed publication ID23086976

P2093author name stringJack D Griffith
N Özlem Arat
P2860cites workMammalian telomeres end in a large duplex loopQ22009893
TIN2, a new regulator of telomere length in human cellsQ22010863
Identification of human Rap1: implications for telomere evolutionQ22254239
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeresQ22254585
Rap1 affects the length and heterogeneity of human telomeresQ24298023
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopyQ24301827
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomesQ24302611
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsQ24304989
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA endsQ24305452
In vivo stoichiometry of shelterin componentsQ24312021
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2Q24317670
TRF1 is a dimer and bends telomeric DNAQ24318291
How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structuresQ24323494
The human Rap1 protein complex and modulation of telomere lengthQ24337452
Telomere maintenance requires the RAD51D recombination/repair proteinQ24338140
NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domainsQ27634722
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organismsQ27666528
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2Q28116237
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNAQ28145077
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeresQ28277505
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalQ28506435
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletionQ28507823
How shelterin protects mammalian telomeresQ29615744
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.Q33293671
Human telomeric proteins occupy selective interstitial sitesQ33851199
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric endsQ33878468
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhangQ34082359
Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenanceQ34864784
Ku acts in a unique way at the mammalian telomere to prevent end joiningQ35207184
TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination.Q35928861
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shorteningQ36020875
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeresQ36149659
Electron microscope visualization of chromatin and other DNA-protein complexesQ36717184
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteinsQ37846533
TRF1 binds a bipartite telomeric site with extreme spatial flexibilityQ38319408
The nature of telomere fusion and a definition of the critical telomere length in human cellsQ40073766
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2Q41829828
Human RAP1 inhibits non-homologous end joining at telomeresQ41952546
Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities.Q42126674
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomerQ42426509
Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit.Q52567833
p53 Monitors replication fork regression by binding to "chickenfoot" intermediates.Q52661409
Visualization of TBP oligomers binding and bending the HIV-1 and adeno promotersQ64383239
The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing featureQ64388283
Human p53 binds Holliday junctions strongly and facilitates their cleavageQ73119545
The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeatsQ79278336
P4510describes a project that usesImageJQ1659584
P433issue50
P407language of work or nameEnglishQ1860
P304page(s)41583-41594
P577publication date2012-10-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleHuman Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere
P478volume287

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cites work (P2860)
Q89575750A Global Screen for Assembly State Changes of the Mitotic Proteome by SEC-SWATH-MS
Q37422064A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
Q36627966A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
Q38206208Biology of telomeres: lessons from budding yeast
Q36539673Complex interactions between the DNA-damage response and mammalian telomeres
Q47255580Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations
Q47588681Dissecting the telomere-inner nuclear membrane interface formed in meiosis.
Q38658025Double-stranded telomeric DNA binding proteins: Diversity matters.
Q92024675Either Rap1 or Cdc13 can protect telomeric single-stranded 3' overhangs from degradation in vitro
Q28551481Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins
Q36545398Heregulin, a new interactor of the telosome/shelterin complex in human telomeres.
Q35171575Human Rap1 modulates TRF2 attraction to telomeric DNA.
Q21263027Human single-stranded DNA binding proteins are essential for maintaining genomic stability
Q36564417Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins
Q33924629Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity
Q33878962PRL-3 promotes telomere deprotection and chromosomal instability
Q41459569Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5' ends
Q35818204Rap1 is indispensable for TRF2 function in etoposide-induced DNA damage response in gastric cancer cell line
Q91972733Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Q36981779Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence
Q42652989Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
Q37742751Stop pulling my strings - what telomeres taught us about the DNA damage response
Q28854371Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation
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Q26744808Telomere and Telomerase Therapeutics in Cancer
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Q26742154Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell
Q48207441Telomeres: Implications for Cancer Development
Q64086139The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability
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Q37401082Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops
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Q35102946Unraveling secrets of telomeres: one molecule at a time.
Q36497430Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids

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