The biogenesis and regulation of telomerase holoenzymes

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The biogenesis and regulation of telomerase holoenzymes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1008687509
P356DOI10.1038/NRM1961
P932PMC publication ID2915765
P698PubMed publication ID16829980
P5875ResearchGate publication ID6955434

P2093author name stringKathleen Collins
P2860cites workA telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
CAJAL BODIES: A Long History of DiscoveryQ22065410
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAsQ22253860
Human telomerase contains two cooperating telomerase RNA moleculesQ24291388
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitorQ24291889
Functional conservation of the telomerase protein Est1p in humansQ24299999
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTRQ24304902
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeresQ24540232
Cell cycle-regulated trafficking of human telomerase to telomeresQ24540240
Identification of two RNA-binding proteins associated with human telomerase RNAQ24548517
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10Q24551042
Human telomerase contains evolutionarily conserved catalytic and structural subunitsQ24604009
Involvement of 14-3-3 proteins in nuclear localization of telomeraseQ24685623
The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteinsQ24793277
A mutant with a defect in telomere elongation leads to senescence in yeastQ27930429
Intracellular trafficking of yeast telomerase components.Q27930619
Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.Q27931258
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interactionQ27932081
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome endsQ27932980
A bulged stem tethers Est1p to telomerase RNA in budding yeastQ27933008
Biogenesis of yeast telomerase depends on the importin mtr10Q27933016
The Est3 protein is a subunit of yeast telomeraseQ27933462
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNAQ27934811
tRNA Maturation: RNA Polymerization without a Nucleic Acid TemplateQ28111738
Functional requirement of p23 and Hsp90 in telomerase complexesQ28115669
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressedQ28116014
An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalizationQ28116246
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptaseQ28138478
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivoQ28140790
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particleQ28144506
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenitaQ28189076
Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymesQ28202297
Nucleolar localization of hTERT protein is associated with telomerase functionQ28207128
Structure and function of telomerase RNAQ28241332
LSm proteins form heptameric rings that bind to RNA via repeating motifsQ28264182
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivoQ28270626
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
Nucleolin interacts with telomeraseQ28282467
Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analysesQ28283946
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in TetrahymenaQ28639814
Telomerase RNA Accumulates in Cajal Bodies in Human Cancer CellsQ34785598
Telomerase: a target for cancer therapeuticsQ34979724
Telomerase: biochemical considerations for enzyme and substrate.Q34989394
Template boundary definition in Tetrahymena telomeraseQ35005581
The many facets of H/ACA ribonucleoproteinsQ35038202
Telomerase: what are the Est proteins doing?Q35145812
Telomeres and telomerase in aging, regeneration and cancer.Q35152949
Functionally interacting telomerase RNAs in the yeast telomerase complexQ35194966
Telomere maintenance and diseaseQ35544622
Telomeres, stem cells, senescence, and cancerQ35628573
T-loops and the origin of telomeresQ35741027
Adding to the ends: what makes telomerase processive and how important is it?Q35880054
Senescence and immortalization: role of telomeres and telomeraseQ35912152
Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA moleculesQ36059261
Telomere length regulation during cloning, embryogenesis and ageing.Q36060940
Telomerase: regulation, function and transformationQ36103259
Mutated PI 3-kinases: cancer targets on a silver platter.Q36117981
Ro's role in RNA reconnaissanceQ36134036
Major cutbacks at chromosome endsQ36152431
Dyskeratosis congenita -- a disease of dysfunctional telomere maintenanceQ36172527
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complexQ36199868
Dyskeratosis congenita: a disorder of defective telomere maintenance?Q36278279
RNA-guided DNA deletion in Tetrahymena: an RNAi-based mechanism for programmed genome rearrangementsQ36312223
Telomere dynamics in genome stabilityQ36365852
Telomere loss: mitotic clock or genetic time bomb?Q36706939
Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primersQ36758147
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Expression of mouse telomerase catalytic subunit in embryos and adult tissues.Q37470406
The nucleolar localization domain of the catalytic subunit of human telomeraseQ38290133
Interference footprinting analysis of telomerase elongation complexesQ38311992
Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.Q38348979
The RNA subunit of telomerase is encoded by Marek's disease virusQ39748978
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.Q39787838
Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein associationQ40315687
Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation.Q40449336
Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenitaQ40519021
Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiencyQ40524103
Subnuclear shuttling of human telomerase induced by transformation and DNA damage.Q40708285
Holoenzyme proteins required for the physiological assembly and activity of telomeraseQ40882874
Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomeraseQ41035726
Template boundary in a yeast telomerase specified by RNA structureQ41734113
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.Q42046068
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.Q42057695
Variable telomeric repeat synthesis in Paramecium tetraurelia is consistent with misincorporation by telomeraseQ42077815
Developmentally programmed gene elimination in Euplotes crassus facilitates a switch in the telomerase catalytic subunitQ42600800
A novel specificity for the primer-template pairing requirement in Tetrahymena telomeraseQ42638798
Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzymeQ42839801
Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomeraseQ43510695
Developmentally programmed healing of chromosomes by telomerase in TetrahymenaQ44487331
The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability.Q46015316
Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lectureQ46194145
Telomerase in yeastQ46265180
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAsQ46821624
Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAsQ46833369
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Q52541918
Shaggy mouse talesQ59096769
Association between aplastic anaemia and mutations in telomerase RNAQ59463050
Telomerase beyond telomeresQ63384203
The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleusQ73193228
Telomere maintenance in fission yeast requires an Est1 orthologQ73216287
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocationQ73720782
Est1p as a cell cycle-regulated activator of telomere-bound telomeraseQ74593218
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase proteinQ78762135
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentationQ81583972
Telomerase recognizes its template by using an adjacent RNA motifQ34067042
Connecting chromosomes, crisis, and cancerQ34141381
Telomerase extracurricular activitiesQ34188137
DNA sequences of telomeres maintained in yeastQ34255911
Interactions between telomerase and primase physically link the telomere and chromosome replication machineryQ34284600
C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activityQ34285674
The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivoQ34363735
Natural selection is not required to explain universal compositional patterns in rRNA secondary structure categoriesQ34366745
Studies on the minimal lengths required for DNA primers to be extended by the Tetrahymena telomerase: implications for primer positioning by the enzymeQ34446174
Extension of G-quadruplex DNA by ciliate telomeraseQ34468325
A novel RNA binding domain in tetrahymena telomerase p65 initiates hierarchical assembly of telomerase holoenzymeQ34519935
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off againQ34527718
The structure and function of telomerase reverse transcriptaseQ34535163
Telomerase in the human organismQ34535632
An emerging consensus for telomerase RNA structureQ34551664
hnRNP A1 associates with telomere ends and stimulates telomerase activityQ34625735
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificityQ34687302
Conservation of the human telomere sequence (TTAGGG)n among vertebratesQ28776595
Cell cycle-dependent regulation of yeast telomerase by Ku.Q29465400
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
Telomeres and human disease: ageing, cancer and beyondQ29615353
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endQ29615761
Regulation of telomerase by telomeric proteinsQ29616133
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
TLC1: template RNA component of Saccharomyces cerevisiae telomeraseQ29618197
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutantsQ30304451
Euplotes telomerase contains an La motif protein produced by apparent translational frameshiftingQ30306373
The Euplotes La motif protein p43 has properties of a telomerase-specific subunitQ30310843
Tetrahymena telomerase is active as a monomerQ30311376
Yeast telomerase RNA: a flexible scaffold for protein subunitsQ30433852
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptaseQ30439454
Inhibition of telomerase by G-quartet DNA structuresQ30450395
Tetrahymena proteins p80 and p95 are not core telomerase componentsQ30453860
Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliatesQ30464344
Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhangQ30469368
Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activityQ30471100
Polyadenylation of telomerase RNA in budding yeastQ30471466
Functional characterization of telomerase RNA variants found in patients with hematologic disordersQ33363749
Template boundary definition in mammalian telomeraseQ33589597
Telomerase can act as a template- and RNA-independent terminal transferaseQ33895952
Stable association of hsp90 and p23, but Not hsp70, with active human telomeraseQ33939931
Ciliate telomerase biochemistryQ33953553
Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomeraseQ33966749
Functional multimerization of the human telomerase reverse transcriptaseQ33969441
RNA binding domain of telomerase reverse transcriptaseQ34011552
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivoQ34012762
A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptaseQ34033932
A physical and functional constituent of telomerase anchor siteQ34049648
Roles for RNA in telomerase nucleotide and repeat addition processivityQ34050439
Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA.Q34050452
The product of the survival of motor neuron (SMN) gene is a human telomerase-associated proteinQ34060945
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cellsQ34063522
P433issue7
P304page(s)484-494
P577publication date2006-07-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleThe biogenesis and regulation of telomerase holoenzymes
P478volume7

Reverse relations

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