Telomerase regulation

scientific article published on 18 October 2011

Telomerase regulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MRFMMM.2011.10.003
P932PMC publication ID3256259
P698PubMed publication ID22032831
P5875ResearchGate publication ID51750538

P50authorDorothy E. ShippenQ88374926
P2093author name stringCatherine Cifuentes-Rojas
P2860cites workThe Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitorQ24291889
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomeraseQ24293589
The POT1-TPP1 telomere complex is a telomerase processivity factorQ24293607
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTRQ24304902
Telomere protection by mammalian Pot1 requires interaction with Tpp1Q24319841
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesisQ24323178
Human telomerase and its regulationQ24533247
Cell cycle-regulated trafficking of human telomerase to telomeresQ24540240
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridizationQ24551148
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivoQ24606587
Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditionsQ24624897
DNA damage signalling prevents deleterious telomere addition at DNA breaksQ24646336
CTCF binds the proximal exonic region of hTERT and inhibits its transcriptionQ24814974
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNAQ27662381
The yeast Pif1p helicase removes telomerase from telomeric DNA.Q27930167
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenanceQ27930358
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome endsQ27932980
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formationQ27933419
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNAQ27934811
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.Q27934948
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsQ28116571
The Myc/Max/Mad network and the transcriptional control of cell behaviorQ28141143
CTCF is a uniquely versatile transcription regulator linked to epigenetics and diseaseQ28214592
Cancer susceptibility and the functions of BRCA1 and BRCA2Q28217784
Switching human telomerase on and off with hPOT1 protein in vitroQ28241841
Functional interaction between telomere protein TPP1 and telomeraseQ28276079
Developmentally programmed gene elimination in Euplotes crassus facilitates a switch in the telomerase catalytic subunitQ42600800
Canis familiaris telomerase reverse transcriptase undergoes alternative splicingQ43631111
Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeresQ44590135
Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.Q47699338
Characterization of Oryza sativa telomerase reverse transcriptase and possible role of its phosphorylation in the control of telomerase activityQ48165561
Telomerase activity in human germline and embryonic tissues and cellsQ49024139
TCAB1: driving telomerase to Cajal bodies.Q51737868
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Q52541918
Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients.Q53520399
Human PIF Helicase is Cell Cycle Regulated and Associates with TelomeraseQ56552037
hTERT gene dosage correlates with telomerase activity in human lung cancer cell linesQ60284667
Tel1p Preferentially Associates with Short Telomeres to Stimulate Their ElongationQ61314294
The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiaeQ63977010
Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinaseQ64388536
Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancerQ67213534
Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cellsQ73155202
The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase geneQ73280057
Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissueQ73393213
Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometriumQ73396764
Cell cycle restriction of telomere elongationQ73761959
Tumour specific regulation of telomerase RNA gene expression visualized by in situ hybridizationQ74371567
Cloning and characterization of rice (Oryza sativa L) telomerase reverse transcriptase, which reveals complex splicing patternsQ74418866
Yeast Ku as a regulator of chromosomal DNA end structureQ74490854
Est1p as a cell cycle-regulated activator of telomere-bound telomeraseQ74593218
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunitQ77388144
Length regulation and dynamics of individual telomere tracts in wild-type ArabidopsisQ80349516
The RNA component of human telomeraseQ28288330
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancersQ28292209
Epidemiologic evidence for a role of telomere dysfunction in cancer etiologyQ28394031
Mechanisms of telomerase induction during vascular smooth muscle cell proliferationQ28572787
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivoQ28589866
Cell cycle-dependent regulation of yeast telomerase by Ku.Q29465400
Mutation in TERT separates processivity from anchor-site functionQ30446605
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenanceQ30921117
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.Q31002474
Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissuesQ33255709
siRNA-mediated methylation of Arabidopsis telomeresQ33604864
Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivoQ33724680
TERRA transcripts are bound by a complex array of RNA-binding proteinsQ33727847
Two RNA subunits and POT1a are components of Arabidopsis telomeraseQ33773225
Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivoQ33890901
Haploinsufficiency of mTR results in defects in telomere elongationQ34019216
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.Q34019245
The biogenesis and regulation of telomerase holoenzymesQ34042917
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomeraseQ34146428
Telomerase Recruitment in Saccharomyces cerevisiae Is Not Dependent on Tel1-Mediated Phosphorylation of Cdc13Q34386854
Telomeres, crisis and cancerQ34428523
Telomerase regulation: not just flipping the switchQ34493169
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulationQ34535640
Telomeres, telomerase and senescenceQ34636650
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.Q34729916
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activityQ34785876
Ever shorter telomere 1 ( EST1 )-dependent reverse transcription by Candida telomerase in vitro : Evidence in support of an activating functionQ35021955
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.Q35041364
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanismsQ35154866
The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.Q35179269
Dyskeratosis congenita as a disorder of telomere maintenanceQ35529338
Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cellsQ35613429
Increased association of telomerase with short telomeres in yeast.Q35893631
Senescence and immortalization: role of telomeres and telomeraseQ35912152
Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiaeQ36012625
Making the most of a little: dosage effects in eukaryotic telomere length maintenanceQ36245192
E2F1 and telomerase: alliance in the dark sideQ36455168
Telomerase therapeutics for cancer: challenges and new directionsQ36506309
Lack of cell cycle regulation of telomerase activity in human cellsQ36592334
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivoQ36700876
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalizationQ36754020
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activityQ36940234
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cellsQ37305023
The conserved Est1 protein stimulates telomerase DNA extension activityQ37394791
BRCA1 localization to the telomere and its loss from the telomere in response to DNA damageQ37479248
TERRA biogenesis, turnover and implications for function.Q37775273
Chromatin and epigenetic regulation of the telomerase reverse transcriptase geneQ37825834
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activityQ38311950
Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiaeQ38321503
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.Q39120582
Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoterQ39397461
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.Q39543159
Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levelsQ39551372
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongationQ39554378
CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase ActivityQ39642191
Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factorsQ40078363
Characterization of a novel effect of hPinX1 on hTERT nucleolar localizationQ40188217
Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters.Q40377912
p53-dependent down-regulation of telomerase is mediated by p21waf1.Q40515208
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancersQ40622531
Subnuclear shuttling of human telomerase induced by transformation and DNA damage.Q40708285
Cloning and expression of hamster telomerase catalytic subunit cDNA.Q40799004
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activityQ40825989
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.Q40907825
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).Q40953506
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcriptsQ41006486
Myc target genesQ41491682
Proteasome-dependent degradation of Est1p regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiaeQ41792156
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.Q42046068
Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.Q42203404
Cell cycle-dependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation in tobacco BY-2 suspension culture cellsQ42518112
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)20-27
P577publication date2011-10-18
P1433published inMutation ResearchQ6943732
P1476titleTelomerase regulation
P478volume730

Reverse relations

cites work (P2860)
Q35663654A transposable element within the Non-canonical telomerase RNA of Arabidopsis thaliana modulates telomerase in response to DNA damage [corrected].
Q36421764An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage
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Q48023136Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites
Q26781157Evolution of TERT-interacting lncRNAs: expanding the regulatory landscape of telomerase
Q24606549Finding the end: recruitment of telomerase to telomeres
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Q37407111MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer
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Q38232447Telomerase promoter mutations in cancer: an emerging molecular biomarker?
Q34293941Telomere fusions in early human breast carcinoma
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Q37007328Urinary bladder cancer susceptibility markers. What do we know about functional mechanisms?
Q38881676Widespread telomere instability in prostatic lesions.
Q33695070miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

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