Making the most of a little: dosage effects in eukaryotic telomere length maintenance

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Making the most of a little: dosage effects in eukaryotic telomere length maintenance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S10577-005-0994-5
P698PubMed publication ID16132814

P2093author name stringLea Harrington
P2860cites workKu binds telomeric DNA in vitroQ22010395
Ku is associated with the telomere in mammalsQ22010717
Rap1 affects the length and heterogeneity of human telomeresQ24298023
Human Ku70/80 interacts directly with hTR, the RNA component of human telomeraseQ24299861
Wild-derived inbred mouse strains have short telomeresQ24528999
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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeresQ24536297
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The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 proteinQ27931011
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Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivoQ36700876
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A bulged stem tethers Est1p to telomerase RNA in budding yeastQ27933008
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Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination eventsQ27936385
Human Ku70/80 associates physically with telomerase through interaction with hTERTQ28115815
Homologous recombination generates T-loop-sized deletions at human telomeresQ28116970
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiationQ28145356
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Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activityQ30471100
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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhangQ33757028
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.Q33757674
The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNAQ33786914
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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouseQ33862948
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisQ33862956
Ku86 is essential in human somatic cellsQ33894543
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in miceQ33914498
Telomere dysfunction triggers developmentally regulated germ cell apoptosis.Q33937428
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Alternative lengthening of telomeres: dangerous road less travelledQ33966399
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.Q33968202
Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiaeQ34012288
Haploinsufficiency of mTR results in defects in telomere elongationQ34019216
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activitiesQ38335557
The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.Q39444293
The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formationQ39574489
Different telomere damage signaling pathways in human and mouse cellsQ39647901
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesisQ39700541
The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.Q39753325
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The zebrafish as a vertebrate model of functional aging and very gradual senescenceQ44509497
Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.Q44564108
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.Q44762653
Involvement of mammalian Mus81 in genome integrity and tumor suppressionQ47323217
A novel mechanism for telomere size control in Saccharomyces cerevisiaeQ47331172
Ndj1p-dependent epigenetic resetting of telomere size in yeast meiosisQ47393050
Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.Q47699338
Length control of human telomeres.Q47997254
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cellsQ48560666
Regulation of tubulin gene expression during embryogenesis in Drosophila melanogaster.Q52527303
Telomerase maintains telomere structure in normal human cells.Q52551445
Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics.Q53360868
Telomere dysfunction and the initiation of genome instability.Q55036686
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome StabilityQ56508014
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient MiceQ56508064
Taking the measureQ59043529
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageingQ59086518
Association between aplastic anaemia and mutations in telomerase RNAQ59463050
Telomerase levels control the lifespan of human T lymphocytesQ60628793
Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosisQ61872130
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Telomerase modulates expression of growth-controlling genes and enhances cell proliferationQ73322990
Synthetic dosage lethalityQ74321407
Telomerase activity in candidate stem cells from fetal liver and adult bone marrowQ74477777
Est1p as a cell cycle-regulated activator of telomere-bound telomeraseQ74593218
Enhanced tumor formation in mice heterozygous for Blm mutationQ74813290
Exploring the etiology of haploinsufficiencyQ77614631
Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instabilityQ78019639
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Msh2 deficiency increases the mutation frequency in all parts of the mouse colonQ78681880
The yeast VPS genes affect telomere length regulationQ81024710
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.Q34019245
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiaeQ34035073
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpressionQ34166733
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Q34181022
Dosage sensitivity and the evolution of gene families in yeastQ34213245
Developmental and tissue-specific regulation of mouse telomerase and telomere lengthQ34265760
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemiaQ34409487
A molecular switch underlies a human telomerase diseaseQ34430499
Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenitaQ34514264
A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere lengthQ34514337
Telomere maintenance without telomeraseQ34535615
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulationQ34535640
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.Q34543987
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeastQ34572690
Dynamics of telomeric DNA turnover in yeastQ34614236
The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenanceQ34616372
Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiaeQ34617934
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.Q34724924
Expanded repeat sequences and diseaseQ34795207
Short telomeres induce a DNA damage response in Saccharomyces cerevisiaeQ34813172
Alternative lengthening of telomeres, telomerase, and cancer.Q35131772
Telomere repeat binding factors: keeping the ends in checkQ35131785
Telomere structure, function and maintenance in ArabidopsisQ35137119
Ku acts in a unique way at the mammalian telomere to prevent end joiningQ35207184
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathwaysQ35218053
Which end: dissecting Ku's function at telomeres and double-strand breaks: Figure 1Q35549049
Chemogenomic profiling: identifying the functional interactions of small molecules in yeastQ35554300
Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeresQ35582993
Alternatives to telomerase: keeping linear chromosomes via telomeric circlesQ35785917
Telomerase activity, cell proliferation, and cancerQ36166271
Telomere cap components influence the rate of senescence in telomerase-deficient yeast cellsQ36222630
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcsQ36322778
Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysisQ36691964
P433issue5
P921main subjecttelomere lengthQ59658244
P304page(s)493-504
P577publication date2005-01-01
P1433published inChromosome ResearchQ15765850
P1476titleMaking the most of a little: dosage effects in eukaryotic telomere length maintenance
P478volume13

Reverse relations

cites work (P2860)
Q33315749Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
Q54657596Leishmania amazonensis: Partial purification and study of the biochemical properties of the telomerase reverse transcriptase activity from promastigote-stage
Q30441223Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency
Q39906810No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells
Q40001546Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation
Q41967731Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes
Q37950142Telomerase regulation
Q37002134Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells
Q34410927Telomere length homeostasis requires that telomerase levels are limiting
Q33933472Telomere length is inherited with resetting of the telomere set-point.
Q37136795Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.

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