Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase

scientific article

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKI342
P3181OpenCitations bibliographic resource ID4729204
P932PMC publication ID1075923
P698PubMed publication ID15824061
P5875ResearchGate publication ID7912946

P2093author name stringSusan P Lees-Miller
Yaping Yu
Tara L Beattie
Nicholas S Y Ting
Brant Pohorelic
P2860cites workKu binds telomeric DNA in vitroQ22010395
Interaction of human Ku70 with TRF2Q24290239
Human telomerase and its regulationQ24533247
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeresQ24536297
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 bindingQ24550780
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent mannerQ24634159
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome endsQ27932980
Human Ku70/80 associates physically with telomerase through interaction with hTERTQ28115815
Secondary structure of vertebrate telomerase RNAQ28138961
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acidsQ28608946
Cell cycle-dependent regulation of yeast telomerase by Ku.Q29465400
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activityQ29615388
Protection of mammalian telomeresQ29618391
Beginning to understand the end of the chromosomeQ30312045
Yeast telomerase RNA: a flexible scaffold for protein subunitsQ30433852
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhangQ33757028
DNA-PKcs is critical for telomere cappingQ33952920
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.Q33968202
Functional multimerization of the human telomerase reverse transcriptaseQ33969441
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Q34181022
UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradationQ34311385
Functional interaction between DNA-PKcs and telomerase in telomere length maintenanceQ34369713
Ku acts in a unique way at the mammalian telomere to prevent end joiningQ35207184
Which end: dissecting Ku's function at telomeres and double-strand breaks: Figure 1Q35549049
Getting to the end: telomerase access in yeast and humansQ35611361
Repair of DNA double strand breaks by non-homologous end joiningQ35630367
Functional links between telomeres and proteins of the DNA-damage responseQ35853775
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Human telomerase RNA-protein interactionsQ39097445
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cellsQ40549393
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunitQ41108271
A phylogenetically based secondary structure for the yeast telomerase RNA.Q43520446
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cellsQ48560666
Telomerase activity and expression of telomerase reverse transcriptase correlated with cell proliferation in meningiomas and malignant brain tumors in vivoQ48788713
Characterization of the RNA binding properties of Ku proteinQ64389129
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectregulation of telomere maintenanceQ14906092
X-ray repair cross complementing 5Q21116582
X-ray repair cross complementing 6Q21116645
P304page(s)2090-8
P577publication date2005-01-01
P1433published inNucleic Acids ResearchQ135122
P1476titleHuman Ku70/80 interacts directly with hTR, the RNA component of human telomerase
P478volume33

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cites work (P2860)
Q34880219A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
Q39815288A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function
Q82300194Altered nuclear functions in progeroid syndromes: a paradigm for aging research
Q35097621Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology
Q36246606Biogenesis of telomerase ribonucleoproteins
Q34743747Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells
Q36532681Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner
Q41970254Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution
Q36144172DNA ends alter the molecular composition and localization of Ku multicomponent complexes
Q36245188DNA repair and recombination functions in Arabidopsis telomere maintenance
Q35638872DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication
Q92980463DNA-dependent protein kinase in telomere maintenance and protection
Q82430042Effect of Ku proteins on IRES-mediated translation
Q91762115Evolutionary and biochemical analyses reveal conservation of the Brassicaceae telomerase ribonucleoprotein complex
Q58862336From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
Q90862796Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq
Q37810521Human telomerase activity regulation.
Q37109884Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.
Q33248448Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro
Q30452553Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
Q96686005LRIK interacts with the Ku70-Ku80 heterodimer enhancing the efficiency of NHEJ repair
Q37052345Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
Q92134232Loss of Ku's DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis
Q36245192Making the most of a little: dosage effects in eukaryotic telomere length maintenance
Q34723491Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
Q26861714Molecular regulation of telomerase activity in aging
Q41319359Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer
Q36768163Noncoding RNAs of the H/ACA family
Q34043691On the road with WRAP53β: guardian of Cajal bodies and genome integrity
Q93104320Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription
Q37022486Physiological assembly and activity of human telomerase complexes
Q30456613RNA recognition by the DNA end-binding Ku heterodimer
Q34130110Ribonucleoprotein multimers and their functions
Q36604651Stacking the DEK: from chromatin topology to cancer stem cells
Q31125909Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes
Q26742154Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell
Q34310430Telomeres at a glance.
Q61814949Telomeres in Plants and Humans: Not So Different, Not So Similar
Q41997598The 5' arm of Kluyveromyces lactis telomerase RNA is critical for telomerase function
Q29465398The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.
Q42086662The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1.
Q24337622The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
Q28480874The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms
Q33773225Two RNA subunits and POT1a are components of Arabidopsis telomerase
Q40110935Uncoupling of telomere length and radiosensitivity in mouse lymphoma cell lines of similar genetic background
Q37175957Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

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