Getting to the end: telomerase access in yeast and humans

scientific article published on December 2003

Getting to the end: telomerase access in yeast and humans is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1006364393
P356DOI10.1038/NRM1256
P698PubMed publication ID14685173

P50authorMaria MateyakQ57731163
P2093author name stringLeticia R Vega
Virginia A Zakian
P2860cites workTankyrase, a poly(ADP-ribose) polymerase at human telomeresQ22008022
Mammalian telomeres end in a large duplex loopQ22009893
Ku is associated with the telomere in mammalsQ22010717
TIN2, a new regulator of telomere length in human cellsQ22010863
A telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
Normal human chromosomes have long G-rich telomeric overhangs at one endQ22065787
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAsQ22253860
Identification of human Rap1: implications for telomere evolutionQ22254239
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeresQ22254585
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpressionQ24291448
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitorQ24291889
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeresQ24291989
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2Q24295044
Functional conservation of the telomerase protein Est1p in humansQ24299999
POT1 as a terminal transducer of TRF1 telomere length controlQ24302841
Human POT1 facilitates telomere elongation by telomeraseQ24303687
A human telomeric proteinQ24304466
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesQ24304488
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndromeQ24316811
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage responseQ24316950
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2Q24317670
TRF1 is a dimer and bends telomeric DNAQ24318291
Control of telomere length by the human telomeric protein TRF1Q24320111
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencingQ24533190
Human telomerase and its regulationQ24533247
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeresQ24536297
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicingQ24538105
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10Q24551042
Control of human telomere length by TRF1 and TRF2Q24554302
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexQ24604459
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridizationQ24657378
Conserved structure for single-stranded telomeric DNA recognitionQ27638743
The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNAQ27732682
Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNAQ27766424
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenanceQ27930358
A mutant with a defect in telomere elongation leads to senescence in yeastQ27930429
Intracellular trafficking of yeast telomerase components.Q27930619
RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stabilityQ68579298
Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNAQ70308671
Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phaseQ70535280
Evidence for a new step in telomere maintenanceQ71046940
Est1 and Cdc13 as comediators of telomerase accessQ73042124
Telomere maintenance in fission yeast requires an Est1 orthologQ73216287
Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational processQ73221736
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocationQ73720782
Cell cycle restriction of telomere elongationQ73761959
Yeast Ku as a regulator of chromosomal DNA end structureQ74490854
The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeresQ74503540
Est1p as a cell cycle-regulated activator of telomere-bound telomeraseQ74593218
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)nQ77353843
hTERT associates with human telomeres and enhances genomic stability and DNA repairQ78794137
Est1 has the properties of a single-stranded telomere end-binding proteinQ27931251
Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites.Q27931439
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interactionQ27932081
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Q27932204
A protein-counting mechanism for telomere length regulation in yeast.Q27932745
Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivoQ27932748
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome endsQ27932980
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicaseQ27933140
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formationQ27933419
The Est3 protein is a subunit of yeast telomeraseQ27933462
Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitmentQ27933598
Cdc13 delivers separate complexes to the telomere for end protection and replicationQ27933636
Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.Q27936665
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeastQ27936734
A RAP1-interacting protein involved in transcriptional silencing and telomere length regulationQ27937220
Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Q27937259
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenanceQ27937328
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivoQ27937905
The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibitionQ27938670
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13Q27938764
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpointQ27939822
Pif1p helicase, a catalytic inhibitor of telomerase in yeastQ27940134
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
Human Ku70/80 associates physically with telomerase through interaction with hTERTQ28115815
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressedQ28116014
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeresQ28119006
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particleQ28144506
Pot1, the putative telomere end-binding protein in fission yeast and humansQ28188476
Nucleolar localization of hTERT protein is associated with telomerase functionQ28207128
The RNA component of human telomeraseQ28288330
Strand-Specific Postreplicative Processing of Mammalian TelomeresQ28315729
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiaeQ29465403
Ku acts in a unique way at the mammalian telomere to prevent end joiningQ35207184
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomeraseQ35936207
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytesQ36338644
Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination eventsQ36646569
Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmidQ36690117
C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiaeQ36705317
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalizationQ36754020
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomesQ36775252
Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere lengthQ37587529
The nucleolar localization domain of the catalytic subunit of human telomeraseQ38290133
An in vitro assay for saccharomyces telomerase requires EST1Q38294059
TRF1 binds a bipartite telomeric site with extreme spatial flexibilityQ38319408
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activitiesQ38335557
Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10pQ38668875
The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.Q39444293
The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formationQ39574489
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomeraseQ39714537
G-strand overhangs on telomeres in telomerase-deficient mouse cellsQ39729234
Putative Telomere-Recruiting Domain in the Catalytic Subunit of Human TelomeraseQ39745847
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.Q39787838
Cdc13 both positively and negatively regulates telomere replicationQ40423693
Subnuclear shuttling of human telomerase induced by transformation and DNA damage.Q40708285
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shorteningQ41121125
Progressive cis-inhibition of telomerase upon telomere elongation.Q41855271
Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.Q43711750
NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomeraseQ44455874
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiaeQ46062549
Telomerase in yeastQ46265180
Catalytically active human telomerase mutants with allele-specific biological propertiesQ46269114
Telomere maintenance is dependent on activities required for end repair of double-strand breaksQ47946099
Mutation of yeast Ku genes disrupts the subnuclear organization of telomeresQ47946111
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cellsQ48560666
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Q52541918
Tankyrase promotes telomere elongation in human cellsQ56969704
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cellsQ57250868
Telomere looping permits gene activation by a downstream UAS in yeastQ59070403
Long Telomeric C-rich 5′-Tails in Human Replicating CellsQ61457965
SGS1 is required for telomere elongation in the absence of telomeraseQ61782242
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomereQ64388053
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiaeQ64389209
Loss of a yeast telomere: arrest, recovery, and chromosome loss.Q64960842
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endQ29615761
TLC1: template RNA component of Saccharomyces cerevisiae telomeraseQ29618197
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutantsQ30304451
Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activityQ30471100
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhangQ33757028
The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNAQ33786914
Telomerase activity in normal and malignant hematopoietic cellsQ33883794
The terminal DNA structure of mammalian chromosomesQ33886897
Repair of chromosome ends after telomere loss in SaccharomycesQ33948830
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptaseQ33964637
Telomere folding is required for the stable maintenance of telomere position effects in yeastQ33966202
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivoQ34012762
A Ku bridge over broken DNA.Q34094139
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenanceQ34411525
Analysis of telomerase in Candida albicans: potential role in telomere end protectionQ34420492
Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?Q34535740
The Mre11 complex: at the crossroads of dna repair and checkpoint signallingQ34623788
Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiaeQ34747590
Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiaeQ34764300
DNA damage and repair in telomeres: relation to agingQ34849875
Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeastQ34910981
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanismsQ34911069
Telomerase: what are the Est proteins doing?Q35145812
Telomere maintenance and DNA replication: how closely are these two connected?Q35193731
P433issue12
P304page(s)948-959
P577publication date2003-12-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleGetting to the end: telomerase access in yeast and humans
P478volume4

Reverse relations

cites work (P2860)
Q36455420A flexible protein linker improves the function of epitope-tagged proteins in Saccharomyces cerevisiae
Q40605554A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication
Q36916532ATM-like kinases and regulation of telomerase: lessons from yeast and mammals
Q54979352Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Q40157259Biochemical properties of Trypanosoma cruzi telomerase
Q38913697Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera
Q35810623Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends
Q37069829Coevolution of telomerase activity and body mass in mammals: from mice to beavers
Q37092750Construction of a tumor-specific bioluminescent eukaryotic expression vector and analysis of its expression in vitro and in vivo
Q27937193Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.
Q24647166Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A
Q36470593Dynamic regulation of single-stranded telomeres in Saccharomyces cerevisiae
Q36478771Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility
Q37323568Function, replication and structure of the mammalian telomere
Q40882874Holoenzyme proteins required for the physiological assembly and activity of telomerase
Q24299861Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
Q21263027Human single-stranded DNA binding proteins are essential for maintaining genomic stability
Q34586455Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA.
Q33980522Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line
Q42641267Inositol diphosphate signaling regulates telomere length
Q40302541Involvement of topoisomerase III in telomere-telomere recombination
Q34609862Kinase-independent functions of TEL1 in telomere maintenance
Q38818114Mammalian telomeres and their partnership with lamins.
Q36177491Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres
Q27932588PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase
Q39892347Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening
Q35676245Positive and negative regulation of Tetrahymena telomerase holoenzyme
Q33649550Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.
Q24624897Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions
Q37235381Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.
Q33836966Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles
Q47384791Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila
Q34682248Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair
Q39240327Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes
Q37143974Rif1 and rif2 inhibit localization of tel1 to DNA ends.
Q33924949Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype.
Q33288733Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase
Q36978932Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
Q38095606Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme
Q27936111Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication
Q54685135Sua5p is required for telomere recombination in Saccharomyces cerevisiae.
Q35672319Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast
Q53882699TELOMERASE ACTIVATOR1 induces telomerase activity and potentiates responses to auxin in Arabidopsis.
Q27934956Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae.
Q83968717Telomerase- and capping-independent yeast survivors with alternate telomere states
Q27930545Telomerase-null survivor screening identifies novel telomere recombination regulators.
Q45314130Telomere Extension By Telomerase
Q45314127Telomere Maintenance
Q49670535Telomere shortening triggers a feedback loop to enhance end protection
Q34194407Telomeres: structures in need of unwinding
Q36024788Telomeres: the beginnings and ends of eukaryotic chromosomes
Q37260573Telomeric RNAs mark sex chromosomes in stem cells.
Q33313458Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation
Q28478064The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro
Q28975759The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
Q90188013The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins
Q38306288The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster
Q35998861The telomerase cycle: normal and pathological aspects
Q35179269The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation.
Q24791591The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus
Q38937312Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.
Q28473883Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres
Q43119254Understanding nuclear organization: when information becomes knowledge. Workshop on Nuclear Organization