review article | Q7318358 |
scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1006364393 |
P356 | DOI | 10.1038/NRM1256 |
P698 | PubMed publication ID | 14685173 |
P50 | author | Maria Mateyak | Q57731163 |
P2093 | author name string | Leticia R Vega | |
Virginia A Zakian | |||
P2860 | cites work | Tankyrase, a poly(ADP-ribose) polymerase at human telomeres | Q22008022 |
Mammalian telomeres end in a large duplex loop | Q22009893 | ||
Ku is associated with the telomere in mammals | Q22010717 | ||
TIN2, a new regulator of telomere length in human cells | Q22010863 | ||
A telomerase component is defective in the human disease dyskeratosis congenita | Q22010917 | ||
Normal human chromosomes have long G-rich telomeric overhangs at one end | Q22065787 | ||
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs | Q22253860 | ||
Identification of human Rap1: implications for telomere evolution | Q22254239 | ||
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres | Q22254585 | ||
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression | Q24291448 | ||
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor | Q24291889 | ||
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres | Q24291989 | ||
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2 | Q24295044 | ||
Functional conservation of the telomerase protein Est1p in humans | Q24299999 | ||
POT1 as a terminal transducer of TRF1 telomere length control | Q24302841 | ||
Human POT1 facilitates telomere elongation by telomerase | Q24303687 | ||
A human telomeric protein | Q24304466 | ||
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases | Q24304488 | ||
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization | Q24310670 | ||
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome | Q24316811 | ||
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response | Q24316950 | ||
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2 | Q24317670 | ||
TRF1 is a dimer and bends telomeric DNA | Q24318291 | ||
Control of telomere length by the human telomeric protein TRF1 | Q24320111 | ||
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing | Q24533190 | ||
Human telomerase and its regulation | Q24533247 | ||
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres | Q24536297 | ||
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing | Q24538105 | ||
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10 | Q24551042 | ||
Control of human telomere length by TRF1 and TRF2 | Q24554302 | ||
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex | Q24604459 | ||
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization | Q24657378 | ||
Conserved structure for single-stranded telomeric DNA recognition | Q27638743 | ||
The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA | Q27732682 | ||
Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA | Q27766424 | ||
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance | Q27930358 | ||
A mutant with a defect in telomere elongation leads to senescence in yeast | Q27930429 | ||
Intracellular trafficking of yeast telomerase components. | Q27930619 | ||
RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability | Q68579298 | ||
Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA | Q70308671 | ||
Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase | Q70535280 | ||
Evidence for a new step in telomere maintenance | Q71046940 | ||
Est1 and Cdc13 as comediators of telomerase access | Q73042124 | ||
Telomere maintenance in fission yeast requires an Est1 ortholog | Q73216287 | ||
Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process | Q73221736 | ||
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation | Q73720782 | ||
Cell cycle restriction of telomere elongation | Q73761959 | ||
Yeast Ku as a regulator of chromosomal DNA end structure | Q74490854 | ||
The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres | Q74503540 | ||
Est1p as a cell cycle-regulated activator of telomere-bound telomerase | Q74593218 | ||
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n | Q77353843 | ||
hTERT associates with human telomeres and enhances genomic stability and DNA repair | Q78794137 | ||
Est1 has the properties of a single-stranded telomere end-binding protein | Q27931251 | ||
Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. | Q27931439 | ||
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction | Q27932081 | ||
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. | Q27932204 | ||
A protein-counting mechanism for telomere length regulation in yeast. | Q27932745 | ||
Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo | Q27932748 | ||
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends | Q27932980 | ||
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase | Q27933140 | ||
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation | Q27933419 | ||
The Est3 protein is a subunit of yeast telomerase | Q27933462 | ||
Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment | Q27933598 | ||
Cdc13 delivers separate complexes to the telomere for end protection and replication | Q27933636 | ||
Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. | Q27936665 | ||
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast | Q27936734 | ||
A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation | Q27937220 | ||
Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. | Q27937259 | ||
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance | Q27937328 | ||
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo | Q27937905 | ||
The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition | Q27938670 | ||
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13 | Q27938764 | ||
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint | Q27939822 | ||
Pif1p helicase, a catalytic inhibitor of telomerase in yeast | Q27940134 | ||
TRF2 Protects Human Telomeres from End-to-End Fusions | Q28111898 | ||
Human Ku70/80 associates physically with telomerase through interaction with hTERT | Q28115815 | ||
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed | Q28116014 | ||
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres | Q28119006 | ||
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle | Q28144506 | ||
Pot1, the putative telomere end-binding protein in fission yeast and humans | Q28188476 | ||
Nucleolar localization of hTERT protein is associated with telomerase function | Q28207128 | ||
The RNA component of human telomerase | Q28288330 | ||
Strand-Specific Postreplicative Processing of Mammalian Telomeres | Q28315729 | ||
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 | Q28609749 | ||
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae | Q29465403 | ||
Ku acts in a unique way at the mammalian telomere to prevent end joining | Q35207184 | ||
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase | Q35936207 | ||
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes | Q36338644 | ||
Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events | Q36646569 | ||
Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid | Q36690117 | ||
C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae | Q36705317 | ||
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization | Q36754020 | ||
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes | Q36775252 | ||
Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length | Q37587529 | ||
The nucleolar localization domain of the catalytic subunit of human telomerase | Q38290133 | ||
An in vitro assay for saccharomyces telomerase requires EST1 | Q38294059 | ||
TRF1 binds a bipartite telomeric site with extreme spatial flexibility | Q38319408 | ||
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities | Q38335557 | ||
Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p | Q38668875 | ||
The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction. | Q39444293 | ||
The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation | Q39574489 | ||
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase | Q39714537 | ||
G-strand overhangs on telomeres in telomerase-deficient mouse cells | Q39729234 | ||
Putative Telomere-Recruiting Domain in the Catalytic Subunit of Human Telomerase | Q39745847 | ||
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. | Q39787838 | ||
Cdc13 both positively and negatively regulates telomere replication | Q40423693 | ||
Subnuclear shuttling of human telomerase induced by transformation and DNA damage. | Q40708285 | ||
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening | Q41121125 | ||
Progressive cis-inhibition of telomerase upon telomere elongation. | Q41855271 | ||
Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. | Q43711750 | ||
NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase | Q44455874 | ||
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae | Q46062549 | ||
Telomerase in yeast | Q46265180 | ||
Catalytically active human telomerase mutants with allele-specific biological properties | Q46269114 | ||
Telomere maintenance is dependent on activities required for end repair of double-strand breaks | Q47946099 | ||
Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres | Q47946111 | ||
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells | Q48560666 | ||
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. | Q52541918 | ||
Tankyrase promotes telomere elongation in human cells | Q56969704 | ||
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells | Q57250868 | ||
Telomere looping permits gene activation by a downstream UAS in yeast | Q59070403 | ||
Long Telomeric C-rich 5′-Tails in Human Replicating Cells | Q61457965 | ||
SGS1 is required for telomere elongation in the absence of telomerase | Q61782242 | ||
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere | Q64388053 | ||
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae | Q64389209 | ||
Loss of a yeast telomere: arrest, recovery, and chromosome loss. | Q64960842 | ||
Telomerase catalytic subunit homologs from fission yeast and human | Q29615387 | ||
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end | Q29615761 | ||
TLC1: template RNA component of Saccharomyces cerevisiae telomerase | Q29618197 | ||
Reverse transcriptase motifs in the catalytic subunit of telomerase | Q29618392 | ||
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants | Q30304451 | ||
Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity | Q30471100 | ||
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang | Q33757028 | ||
The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA | Q33786914 | ||
Telomerase activity in normal and malignant hematopoietic cells | Q33883794 | ||
The terminal DNA structure of mammalian chromosomes | Q33886897 | ||
Repair of chromosome ends after telomere loss in Saccharomyces | Q33948830 | ||
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase | Q33964637 | ||
Telomere folding is required for the stable maintenance of telomere position effects in yeast | Q33966202 | ||
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo | Q34012762 | ||
A Ku bridge over broken DNA. | Q34094139 | ||
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance | Q34411525 | ||
Analysis of telomerase in Candida albicans: potential role in telomere end protection | Q34420492 | ||
Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? | Q34535740 | ||
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling | Q34623788 | ||
Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae | Q34747590 | ||
Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae | Q34764300 | ||
DNA damage and repair in telomeres: relation to aging | Q34849875 | ||
Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast | Q34910981 | ||
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms | Q34911069 | ||
Telomerase: what are the Est proteins doing? | Q35145812 | ||
Telomere maintenance and DNA replication: how closely are these two connected? | Q35193731 | ||
P433 | issue | 12 | |
P304 | page(s) | 948-959 | |
P577 | publication date | 2003-12-01 | |
P1433 | published in | Nature Reviews Molecular Cell Biology | Q1573120 |
P1476 | title | Getting to the end: telomerase access in yeast and humans | |
P478 | volume | 4 |
Q36455420 | A flexible protein linker improves the function of epitope-tagged proteins in Saccharomyces cerevisiae |
Q40605554 | A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication |
Q36916532 | ATM-like kinases and regulation of telomerase: lessons from yeast and mammals |
Q54979352 | Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. |
Q40157259 | Biochemical properties of Trypanosoma cruzi telomerase |
Q38913697 | Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera |
Q35810623 | Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends |
Q37069829 | Coevolution of telomerase activity and body mass in mammals: from mice to beavers |
Q37092750 | Construction of a tumor-specific bioluminescent eukaryotic expression vector and analysis of its expression in vitro and in vivo |
Q27937193 | Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA. |
Q24647166 | Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A |
Q36470593 | Dynamic regulation of single-stranded telomeres in Saccharomyces cerevisiae |
Q36478771 | Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility |
Q37323568 | Function, replication and structure of the mammalian telomere |
Q40882874 | Holoenzyme proteins required for the physiological assembly and activity of telomerase |
Q24299861 | Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase |
Q21263027 | Human single-stranded DNA binding proteins are essential for maintaining genomic stability |
Q34586455 | Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. |
Q33980522 | Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line |
Q42641267 | Inositol diphosphate signaling regulates telomere length |
Q40302541 | Involvement of topoisomerase III in telomere-telomere recombination |
Q34609862 | Kinase-independent functions of TEL1 in telomere maintenance |
Q38818114 | Mammalian telomeres and their partnership with lamins. |
Q36177491 | Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres |
Q27932588 | PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase |
Q39892347 | Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening |
Q35676245 | Positive and negative regulation of Tetrahymena telomerase holoenzyme |
Q33649550 | Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance. |
Q24624897 | Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions |
Q37235381 | Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13. |
Q33836966 | Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles |
Q47384791 | Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila |
Q34682248 | Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair |
Q39240327 | Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes |
Q37143974 | Rif1 and rif2 inhibit localization of tel1 to DNA ends. |
Q33924949 | Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype. |
Q33288733 | Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase |
Q36978932 | Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications |
Q38095606 | Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme |
Q27936111 | Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication |
Q54685135 | Sua5p is required for telomere recombination in Saccharomyces cerevisiae. |
Q35672319 | Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast |
Q53882699 | TELOMERASE ACTIVATOR1 induces telomerase activity and potentiates responses to auxin in Arabidopsis. |
Q27934956 | Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. |
Q83968717 | Telomerase- and capping-independent yeast survivors with alternate telomere states |
Q27930545 | Telomerase-null survivor screening identifies novel telomere recombination regulators. |
Q45314130 | Telomere Extension By Telomerase |
Q45314127 | Telomere Maintenance |
Q49670535 | Telomere shortening triggers a feedback loop to enhance end protection |
Q34194407 | Telomeres: structures in need of unwinding |
Q36024788 | Telomeres: the beginnings and ends of eukaryotic chromosomes |
Q37260573 | Telomeric RNAs mark sex chromosomes in stem cells. |
Q33313458 | Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation |
Q28478064 | The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro |
Q28975759 | The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis |
Q90188013 | The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins |
Q38306288 | The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster |
Q35998861 | The telomerase cycle: normal and pathological aspects |
Q35179269 | The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. |
Q24791591 | The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus |
Q38937312 | Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. |
Q28473883 | Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres |
Q43119254 | Understanding nuclear organization: when information becomes knowledge. Workshop on Nuclear Organization |