A mutant with a defect in telomere elongation leads to senescence in yeast

scientific article

A mutant with a defect in telomere elongation leads to senescence in yeast is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/0092-8674(89)90132-3
P3181OpenCitations bibliographic resource ID1100556
P698PubMed publication ID2655926
P5875ResearchGate publication ID20500147

P2093author name stringJ W Szostak
V Lundblad
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectEst1p YLR233CQ27547434
P304page(s)633-43
P577publication date1989-05-19
P1433published inCellQ655814
P1476titleA mutant with a defect in telomere elongation leads to senescence in yeast
P478volume57

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cites work (P2860)
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Q27934365TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
Q37425009TEN1 is essential for CDC13-mediated telomere capping
Q54918483TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast.
Q28480420TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends
Q24656014TERRA: telomeric repeat-containing RNA
Q29393384THE COMPLEX STRUCTURE AND DYNAMIC EVOLUTION OF HUMAN SUBTELOMERES
Q27931281TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres
Q33379093TOR regulates cell death induced by telomere dysfunction in budding yeast
Q24318291TRF1 is a dimer and bends telomeric DNA
Q27936234Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.
Q34578043Telomerase RNA levels limit the telomere length equilibrium
Q46806433Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
Q33962968Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
Q34386854Telomerase Recruitment in Saccharomyces cerevisiae Is Not Dependent on Tel1-Mediated Phosphorylation of Cdc13
Q54937727Telomerase activity and metastasis: expansion of cells having higher telomerase activity within culture lines and tumor tissues.
Q35142569Telomerase activity in human ovarian carcinoma
Q30472155Telomerase and chromosome end maintenance.
Q37975743Telomerase and telomere-associated proteins: structural insights into mechanism and evolution
Q37497995Telomerase at the intersection of cancer and aging
Q36068547Telomerase catalysis: a phylogenetically conserved reverse transcriptase
Q33373337Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae
Q33533965Telomerase enzyme activation and human cell immortalization
Q46265180Telomerase in yeast
Q35144782Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3' ends in Saccharomyces cerevisiae
Q37382464Telomerase regulation during entry into the cell cycle in normal human T cells
Q36012625Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae
Q33710697Telomerase structure
Q43179667Telomerase- and Rad52-independent immortalization of budding yeast by an inherited-long-telomere pathway of telomeric repeat amplification.
Q83968717Telomerase- and capping-independent yeast survivors with alternate telomere states
Q40294605Telomerase- and recombination-independent immortalization of budding yeast
Q28140790Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo
Q33616690Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres
Q73221736Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
Q27930545Telomerase-null survivor screening identifies novel telomere recombination regulators.
Q33665866Telomerase: Dr Jekyll or Mr Hyde?
Q33536623Telomerases
Q41510242Telomere change and loss of heterozygosity of mouse primary tumors and cell lines
Q41100498Telomere control of replicative lifespan
Q41583660Telomere dynamics and telomerase activity in in vitro immortalised human cells.
Q34059767Telomere dynamics in an immortal human cell line
Q37906713Telomere dynamics: the influence of folate and DNA methylation
Q40146902Telomere dysfunction and inactivation of the p16(INK4a)/Rb pathway in pyothorax-associated lymphoma
Q35629126Telomere dysfunction as a cause of genomic instability in Werner syndrome
Q43709760Telomere dysfunction increases mutation rate and genomic instability
Q33937428Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
Q41035726Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
Q43585922Telomere elongation frequently observed during tumor metastasis
Q56508218Telomere end-replication problem and cell aging
Q34012865Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination
Q35291052Telomere fusions caused by mutating the terminal region of telomeric DNA
Q25257733Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.
Q36163972Telomere length constancy during aging of Saccharomyces cerevisiae
Q71123575Telomere length does not change during senescence of the ascomycete Podospora anserina
Q90689187Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres
Q36495238Telomere length homeostasis
Q47699338Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.
Q36709911Telomere length homeostasis responds to changes in intracellular dNTP pools
Q29615745Telomere length predicts replicative capacity of human fibroblasts
Q38219036Telomere length regulation in budding yeasts
Q37293044Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.
Q35132547Telomere length, telomere-binding proteins, and DNA damage signaling
Q36706939Telomere loss: mitotic clock or genetic time bomb?
Q37260568Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.
Q40839283Telomere maintenance by recombination in human cells.
Q73216287Telomere maintenance in fission yeast requires an Est1 ortholog
Q38759188Telomere maintenance in soft tissue sarcomas
Q33963894Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA
Q34293590Telomere maintenance mechanisms as a target for drug development
Q34535615Telomere maintenance without telomerase
Q36245204Telomere maintenance, function and evolution: the yeast paradigm.
Q24681584Telomere rapid deletion regulates telomere length in Arabidopsis thaliana
Q38964053Telomere recombination pathways: tales of several unhappy marriages.
Q35110580Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors
Q34037761Telomere reduction in human colorectal carcinoma and with ageing
Q35142887Telomere replication: an Est fest
Q24598974Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
Q24617599Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
Q29615388Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
Q24812475Telomere structure and shortening in telomerase-deficient Trypanosoma brucei
Q38866635Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis
Q36105838Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice
Q33960380Telomere-mediated plasmid segregation in Saccharomyces cerevisiae involves gene products required for transcriptional repression at silencers and telomeres
Q39449233Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
Q56508295Telomeres
Q67845653Telomeres
Q33863067Telomeres and HIV disease
Q54125877Telomeres and double-strand breaks: trying to make ends meet.
Q34571596Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Q91559488Telomeres and telomerase: three decades of progress
Q40797773Telomeres and telomerases
Q34090772Telomeres and their control
Q37946045Telomeres and their synthesis
Q46072719Telomeres in the '80s: a few recollections
Q29547357Telomeres shorten during ageing of human fibroblasts
Q37068373Telomeres — what's new at the end?
Q33740892Telomeres: protecting chromosomes against genome instability
Q63977008Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
Q37419279Telomeric armor: the layers of end protection
Q33566396Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination
Q34764300Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
Q28116571Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
Q40631911Telomeric repeat sequences
Q37627970Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase
Q27938764Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13
Q37538214Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast
Q42566913Tetrahymena mutants with short telomeres
Q39574489The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation
Q54732983The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.
Q27937483The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae
Q34616372The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance
Q33786914The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA
Q27933462The Est3 protein is a subunit of yeast telomerase
Q30433767The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro
Q40172226The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini
Q29465398The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.
Q48305214The Nobel Prize in Physiology or Medicine 2009 “for telomere biology” and its relevance to cancer and related diseases
Q39753325The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.
Q40173791The Rap1p-Telomere Complex Does Not Determine the Replicative Capacity of Telomerase-Deficient Yeast
Q39714537The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
Q28478064The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro
Q37385611The Slavery of the h-index-Measuring the Unmeasurable
Q91804736The Spectrum of Hepatic Involvement in Patients With Telomere Disease
Q28975759The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
Q46015316The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability.
Q34571531The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recruitment subunit Est1p
Q30668642The asymmetry of telomere replication contributes to replicative senescence heterogeneity
Q34604224The autolysis of industrial filamentous fungi
Q36290878The biochemistry of mammalian senescence
Q34042917The biogenesis and regulation of telomerase holoenzymes
Q34014665The budding yeast nucleus.
Q36558592The catalytic subunit of yeast telomerase
Q36237437The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
Q39392359The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations.
Q37394791The conserved Est1 protein stimulates telomerase DNA extension activity
Q38597517The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation
Q34810908The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
Q34236105The ends have arrived
Q40723856The genetics of aging in the yeast Saccharomyces cerevisiae
Q27930828The hsp90 molecular chaperone modulates multiple telomerase activities
Q80818316The identification of telomerase subunits: catalysing telomere research
Q41583649The implications of telomerase biochemistry for human disease
Q38678854The length of telomeric G-rich strand 3'-overhang measured by oligonucleotide ligation assay
Q37063130The length of the shortest telomere as the major determinant of the onset of replicative senescence
Q91886890The many types of heterogeneity in replicative senescence
Q41019831The molecular mechanism of ligand unbinding from the human telomeric G-quadruplex by steered molecular dynamics and umbrella sampling simulations
Q37397445The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae
Q34016553The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres
Q44145162The rate of terminal nucleotide loss from a telomere of the mosquito Anopheles gambiae
Q27934097The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p
Q35730263The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactis
Q74503540The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres
Q41216084The roles of telomeres and telomerase in cell life span
Q43564469The telomere-linked helicase (TLH) gene family in Magnaporthe oryzae: revised gene structure reveals a novel TLH-specific protein motif
Q35651048The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro
Q34993950The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain
Q30471100Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
Q38512280Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telo
Q38937312Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.
Q35851857Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae
Q42617375Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs
Q33736728Tumor suppression by p53: making cells senescent
Q28473883Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres
Q30657828Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages
Q37598805Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors.
Q36256436Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
Q38115589Updates on the biology and management of dyskeratosis congenita and related telomere biology disorders
Q67474894Use of non-denaturing Southern hybridization and two dimensional agarose gels to detect putative intermediates in telomere replication inSaccharomyces cerevisiae
Q34128610WI-38 senescence is associated with global and site-specific hypomethylation
Q27932772Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase.
Q27930584Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length
Q27933400Yeast homolog of a cancer-testis antigen defines a new transcription complex
Q36994681Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.
Q30407415Yeast sirtuins and the regulation of aging
Q30433852Yeast telomerase RNA: a flexible scaffold for protein subunits
Q27933320Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation
Q68526251Yeast telomere length varies in response to changes in the amount of polyC1-3A in the cell
Q35210267Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA
Q71387702rTP: a candidate telomere protein that is associated with DNA replication

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