The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance

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The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance is …
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scholarly articleQ13442814

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P932PMC publication ID1462332
P698PubMed publication ID12454059

P50authorVictoria LundbladQ18632404
P2093author name stringSara K Evans
P2860cites workRapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenanceQ27930358
A mutant with a defect in telomere elongation leads to senescence in yeastQ27930429
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 proteinQ27931011
Est1 has the properties of a single-stranded telomere end-binding proteinQ27931251
Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.Q27931258
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interactionQ27932081
The Est3 protein is a subunit of yeast telomeraseQ27933462
Cdc13 delivers separate complexes to the telomere for end protection and replicationQ27933636
Programmed translational frameshifting in a gene required for yeast telomere replicationQ27936627
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particleQ28144506
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutantsQ30304451
Themes in RNA-protein recognition.Q30323241
Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activityQ30471100
TelomerasesQ33536623
The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNAQ33786914
Mammalian telomeres and telomeraseQ33912893
Positive and negative regulation of telomerase access to the telomereQ34030866
Telomeres and their controlQ34090772
Turning telomeres off and on.Q34245353
The catalytic subunit of yeast telomeraseQ36558592
A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptorQ37517460
Association of the Est1 protein with telomerase activity in yeastQ37677320
Protein-RNA interactions: a structural analysisQ38658598
Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactionsQ46112210
Telomerase in yeastQ46265180
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitroQ46806433
Telomere maintenance is dependent on activities required for end repair of double-strand breaksQ47946099
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Q52541918
Est1 and Cdc13 as comediators of telomerase accessQ73042124
Cell cycle restriction of telomere elongationQ73761959
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenanceQ74113048
Est1p as a cell cycle-regulated activator of telomere-bound telomeraseQ74593218
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
telomere lengthQ59658244
P1104number of pages15
P304page(s)1101-1115
P577publication date2002-11-01
P1433published inGeneticsQ3100575
P1476titleThe Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance
P478volume162

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cites work (P2860)
Q27933008A bulged stem tethers Est1p to telomerase RNA in budding yeast
Q41947741A new telomerase RNA element that is critical for telomere elongation
Q35534966A second essential function of the Est1-binding arm of yeast telomerase RNA.
Q34141723A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity
Q27664455Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation
Q38085607Cdc13 at a crossroads of telomerase action
Q41787808Est1 protects telomeres and inhibits subtelomeric y'-element recombination
Q35021955Ever shorter telomere 1 ( EST1 )-dependent reverse transcription by Candida telomerase in vitro : Evidence in support of an activating function
Q37194197Evolutionary perspectives of telomerase RNA structure and function.
Q37323568Function, replication and structure of the mammalian telomere
Q24619822Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and rapamycin resistance
Q39208015Genome-wide studies of telomere biology in budding yeast
Q43877520Identification of additional telomerase component of the yeast H. polymorpha is a step towards understanding the complex at the atomic level.
Q35893631Increased association of telomerase with short telomeres in yeast.
Q33783148Investigating the role of the Est3 protein in yeast telomere replication
Q34609862Kinase-independent functions of TEL1 in telomere maintenance
Q30452553Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
Q92134232Loss of Ku's DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis
Q36245192Making the most of a little: dosage effects in eukaryotic telomere length maintenance
Q42213429Modulation of telomere terminal structure by telomerase components in Candida albicans
Q37072132Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype
Q40207099Mutual dependence of Candida albicans Est1p and Est3p in telomerase assembly and activation
Q34057250Normal telomere length maintenance in Saccharomyces cerevisiae requires nuclear import of the ever shorter telomeres 1 (Est1) protein via the importin alpha pathway
Q27934811Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA
Q37619098Plasticity of telomere maintenance mechanisms in yeast
Q27938923Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation
Q37317740RNA connectivity requirements between conserved elements in the core of the yeast telomerase RNP.
Q27939516RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts
Q27935645Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex
Q34930176Replication proteins influence the maintenance of telomere length and telomerase protein stability
Q39196786Role of the ESCRT Complexes in Telomere Biology
Q35762628Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay
Q47241816Structural Insights into Yeast Telomerase Recruitment to Telomeres.
Q37349785Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase
Q33531384Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1
Q27931281TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres
Q37293044Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.
Q37159901The Est3 protein associates with yeast telomerase through an OB-fold domain
Q40172226The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini
Q28975759The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
Q37394791The conserved Est1 protein stimulates telomerase DNA extension activity
Q36183565The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements
Q34016553The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres
Q35998861The telomerase cycle: normal and pathological aspects
Q81024710The yeast VPS genes affect telomere length regulation
Q39241123The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo
Q88732525The yeast telomerase module for telomere recruitment requires a specific RNA architecture
Q36783587Translocation of Saccharomyces cerevisiae Pif1 helicase monomers on single-stranded DNA.
Q47350265Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo
Q30433852Yeast telomerase RNA: a flexible scaffold for protein subunits
Q27933320Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation

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