Telomere length homeostasis responds to changes in intracellular dNTP pools

scientific article published on 18 January 2013

Telomere length homeostasis responds to changes in intracellular dNTP pools is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/GENETICS.112.149120
P932PMC publication ID3606089
P698PubMed publication ID23335335
P5875ResearchGate publication ID234703638

P50authorJoachim LingnerQ55302211
Rodney RothsteinQ56908395
Michael ChangQ37393331
Andrei ChabesQ41166314
P2093author name stringSushma Sharma
Patrick Reichenbach
Anna Karin Nilsson
Lisette Marjavaara
Amitabha Gupta
P2860cites workThe human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.Q25257733
Functional profiling of the Saccharomyces cerevisiae genomeQ27860544
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.Q27930226
A mutant with a defect in telomere elongation leads to senescence in yeastQ27930429
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Q27932089
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.Q27934371
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressorQ27935222
Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.Q27936234
Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levelsQ27936718
A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP poolsQ27938474
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayQ27938580
Getting started with yeastQ28131602
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.Q42950211
Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomeraseQ43510695
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductaseQ44311904
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductaseQ45078328
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.Q45944819
Telomerase in yeastQ46265180
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAsQ46821624
Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.Q47699338
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia geneQ48070727
Effect of dGTP concentration on human and CHO telomeraseQ73187861
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenanceQ74113048
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damageQ28343318
Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP poolsQ28478063
Conservation of the human telomere sequence (TTAGGG)n among vertebratesQ28776595
Telomeres shorten during ageing of human fibroblastsQ29547357
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
A survey of telomerase activity in human cancerQ29614858
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
Physiological concentrations of purines and pyrimidinesQ29616721
TLC1: template RNA component of Saccharomyces cerevisiae telomeraseQ29618197
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
dGTP-dependent processivity and possible template switching of euplotes telomeraseQ30470926
Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocationQ30471962
Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunitQ33374228
Telomerase-dependent repeat divergence at the 3' ends of yeast telomeresQ33616690
Syndromes of telomere shorteningQ33638357
Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutantsQ33700062
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerasesQ33740206
Molecular basis for telomere repeat divergence in budding yeastQ34012621
Telomere length homeostasis requires that telomerase levels are limitingQ34410927
Long telomeres are preferentially extended during recombination-mediated telomere maintenanceQ34768135
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductaseQ35633411
Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiaeQ36012625
Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiaeQ36561802
Yeast telomerase is capable of limited repeat addition processivityQ37067670
Telomeric strategies: means to an end.Q37806779
Telomerase structure function.Q37822118
Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae.Q38316253
Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiaeQ38321503
Interactions between deoxyribonucleotide and DNA synthesisQ39532113
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpointQ42738775
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttelomere lengthQ59658244
P1104number of pages11
P304page(s)1095-1105
P577publication date2013-01-18
P1433published inGeneticsQ3100575
P1476titleTelomere length homeostasis responds to changes in intracellular dNTP pools
P478volume193

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cites work (P2860)
Q39113436A Critical Balance: dNTPs and the Maintenance of Genome Stability
Q93270681A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
Q89901313A user-friendly, high-throughput tool for the precise fluorescent quantification of deoxyribonucleoside triphosphates from biological samples
Q35616094Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
Q38572102Deoxyribonucleotide metabolism, mutagenesis and cancer
Q38220118Deoxyribonucleotides as genetic and metabolic regulators
Q90428476High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase
Q55213963Histone depletion prevents telomere fusions in pre-senescent cells.
Q39632964Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase.
Q39025697Mitochondrial purine and pyrimidine metabolism and beyond
Q36080100Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae
Q36709924Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae
Q35956253Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent on the Shu Complex
Q47628340Rnr1's role in telomere elongation cannot be replaced by Rnr3: a role beyond dNTPs?
Q42517422Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.
Q38737130Shorter telomeres and high telomerase activity correlate with a highly aggressive phenotype in breast cancer cell lines
Q52648657Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.
Q90910043Tel1 Activation by the MRX Complex Is Sufficient for Telomere Length Regulation but Not for the DNA Damage Response in Saccharomyces cerevisiae
Q92484283Telomere attrition: metabolic regulation and signalling function?
Q40164385Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups
Q37143515The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.
Q58325845Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in

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