scholarly article | Q13442814 |
P50 | author | Karl Lenhard Rudolph | Q21491023 |
P2093 | author name string | C Zhu | |
J Chaudhuri | |||
K K Wong | |||
R A DePinho | |||
S Chang | |||
S Ganesan | |||
F W Alt | |||
L Chin | |||
S E Artandi | |||
G J Gottlieb | |||
S R Weiler | |||
P2860 | cites work | Telomere shortening and tumor formation by mouse cells lacking telomerase RNA | Q29615386 |
Essential role of mouse telomerase in highly proliferative organs | Q29620451 | ||
Sir-Ku-itous routes to make ends meet | Q33684024 | ||
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis | Q33862956 | ||
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient | Q33867168 | ||
Homology-directed repair is a major double-strand break repair pathway in mammalian cells | Q36065571 | ||
Chromosome healing in mouse embryonic stem cells | Q36381066 | ||
SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells | Q39720624 | ||
Telomeres and radiation-induced chromosome breakage | Q41061466 | ||
Regulation and repair of double-strand DNA breaks | Q41262073 | ||
Impairment of V(D)J recombination in double-strand break repair mutants | Q41560292 | ||
Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break | Q41576120 | ||
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals | Q45246384 | ||
Growth retardation and leaky SCID phenotype of Ku70-deficient mice. | Q52191949 | ||
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice | Q56508064 | ||
Telomere capture stabilizes chromosome breakage | Q58321639 | ||
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction | Q64386856 | ||
Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice | Q73692219 | ||
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination | Q77398644 | ||
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes | Q22007974 | ||
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast | Q27936427 | ||
MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks | Q28137625 | ||
Genetic analysis of BRCA1 function in a defined tumor cell line | Q28142643 | ||
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination | Q28272412 | ||
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis | Q28292871 | ||
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV | Q28504490 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 85-8 | |
P577 | publication date | 2000-09-01 | |
P1433 | published in | Nature Genetics | Q976454 |
P1476 | title | Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation | |
P478 | volume | 26 |
Q29615919 | A DNA damage checkpoint response in telomere-initiated senescence |
Q29301431 | A highly selective telomerase inhibitor limiting human cancer cell proliferation |
Q33375057 | A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis |
Q38279200 | A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor |
Q61811967 | ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition |
Q28082599 | Aging and radiation: bad companions |
Q39678514 | Association of telomerase activity with radio- and chemosensitivity of neuroblastomas |
Q46517847 | C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p |
Q74046006 | Caps and cancer |
Q34416433 | Cellular senescence, cancer and aging: the telomere connection |
Q54335200 | Changes in telomere length distribution in low-dose X-ray-irradiated human umbilical vein endothelial cells. |
Q34727255 | Chromosomal aberrations: formation, identification and distribution |
Q64238033 | Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans |
Q33566461 | Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase |
Q37732319 | Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice |
Q45194042 | Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage |
Q39176621 | Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres |
Q35835972 | DNA damage checkpoint kinase Chk2 triggers replicative senescence |
Q28511262 | DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse |
Q42503436 | Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres |
Q37646957 | Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice |
Q40529799 | Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas |
Q58579018 | Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivity |
Q40241243 | Efficient inhibition of human telomerase activity by antisense oligonucleotides sensitizes cancer cells to radiotherapy. |
Q37018003 | Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs |
Q28588253 | Essential role of limiting telomeres in the pathogenesis of Werner syndrome |
Q61443058 | Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length |
Q35871249 | Expression of human protection of telomere 1 correlates with telomere length and radiosensitivity in the human laryngeal cancer Hep-2 cell line |
Q35853775 | Functional links between telomeres and proteins of the DNA-damage response |
Q33565837 | Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast |
Q35868053 | Genetic susceptibility to tobacco-related cancer |
Q28506379 | Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice |
Q34549397 | Genomic instability in both wild-type and telomerase null MEFs |
Q38725326 | Genotoxic risk of ethyl-paraben could be related to telomere shortening |
Q36254687 | Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound |
Q90717619 | Hole Migration in Telomere-Based Oligonucleotide Anions and G-Quadruplexes |
Q24650122 | Human Heterochromatin Protein 1 Isoforms HP1Hsα and HP1Hsβ Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation |
Q39787838 | Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. |
Q34994580 | Immunological disorders and DNA repair |
Q38325760 | Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function |
Q36610782 | Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? |
Q36640182 | Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging |
Q39433499 | Loss of telomere protection: consequences and opportunities. |
Q51708042 | Lymphocyte telomere length correlates with in vitro radiosensitivity in breast cancer cases but is not predictive of acute normal tissue reactions to radiotherapy. |
Q50020640 | Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans. |
Q36245192 | Making the most of a little: dosage effects in eukaryotic telomere length maintenance |
Q41813386 | Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair |
Q35569699 | Mammalian telomeres and telomerase: why they matter for cancer and aging |
Q34535647 | Many ways to telomere dysfunction: in vivo studies using mouse models |
Q44200256 | Massive telomere loss is an early event of DNA damage-induced apoptosis |
Q33937189 | Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging |
Q35044415 | Molecular adaptation of telomere associated genes in mammals |
Q34990657 | Molecular parameters of hyperthermia for radiosensitization |
Q35003946 | Mouse models to study the role of telomeres in cancer, aging and DNA repair |
Q31038583 | Natural and pharmacological regulation of telomerase |
Q39906810 | No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells |
Q37833939 | Non-telomeric activities of telomerase. |
Q36377992 | Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability |
Q36709924 | Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae |
Q39933637 | Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. |
Q33715780 | On the capturing of low-energy electrons by DNA. |
Q24793970 | Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2 |
Q50089780 | PAF promotes stemness and radioresistance of glioma stem cells. |
Q35096706 | Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase |
Q34550319 | Phosphorylation of H2AX at short telomeres in T cells and fibroblasts |
Q37158545 | PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis |
Q38139571 | Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia |
Q36450435 | Radiation Sensitivity and Radiation Necrosis in the Short Telomere Syndromes |
Q40193218 | Radiation-induced effects on telomerase in gynecological cancer cell lines with different radiosensitivity and repair capacity |
Q39144903 | Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. |
Q42731036 | Radioresistance of GGG sequences to prompt strand break formation from direct-type radiation damage |
Q24796117 | Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts |
Q34930176 | Replication proteins influence the maintenance of telomere length and telomerase protein stability |
Q40145760 | Retrospective cohort study and biobanking of patients treated for hemangioma in childhood - telomeres as biomarker of aging and radiation exposure |
Q35661345 | Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints |
Q40728995 | Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells |
Q35125971 | Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer |
Q57803557 | Short telomere syndromes cause a primary T cell immunodeficiency |
Q34813172 | Short telomeres induce a DNA damage response in Saccharomyces cerevisiae |
Q34212939 | Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. |
Q36368282 | Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals |
Q28115535 | Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs |
Q34280196 | Stress, DNA damage and ageing -- an integrative approach |
Q33638357 | Syndromes of telomere shortening |
Q39146154 | TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines |
Q46788573 | TERT promotes cellular and organismal survival independently of telomerase activity |
Q42701089 | TRAPping telomerase within the intestinal stem cell niche |
Q89475391 | Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers |
Q38744397 | Targeting telomerase with radiolabeled inhibitors. |
Q37078833 | Telomerase and cancer therapeutics |
Q37706670 | Telomerase antagonist imetelstat increases radiation sensitivity in esophageal squamous cell carcinoma |
Q40382781 | Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma |
Q35597618 | Telomerase as a novel and potentially selective target for cancer chemotherapy |
Q33373337 | Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae |
Q35812423 | Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy |
Q37542029 | Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer |
Q34688638 | Telomerase inhibition and the future management of head-and-neck cancer |
Q34535598 | Telomerase is not an oncogene |
Q24310084 | Telomerase modulates Wnt signalling by association with target gene chromatin |
Q43897827 | Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors |
Q39509434 | Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells |
Q40533327 | Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging |
Q34572081 | Telomerase: biology and phase I trials |
Q34983035 | Telomere attrition and Chk2 activation in human heart failure |
Q36103575 | Telomere biology: integrating chromosomal end protection with DNA damage response |
Q59086518 | Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing |
Q78560248 | Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant |
Q33948004 | Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors |
Q55036777 | Telomere dysfunction: a potential cancer predisposition factor. |
Q34535652 | Telomere dysfunction: multiple paths to the same end. |
Q36397223 | Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer |
Q40537821 | Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress |
Q34445288 | Telomere profiling: toward glioblastoma personalized medicine |
Q41918210 | Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. |
Q35597009 | Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells |
Q38023894 | Telomere shortening and ionizing radiation: a possible role in vascular dysfunction? |
Q28509192 | Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes |
Q39460276 | Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells |
Q35049411 | Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells |
Q35131777 | Telomere-driven genomic instability in cancer cells. |
Q36309657 | Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis |
Q35062454 | Telomeres and cancer: a tale with many endings |
Q37627017 | Telomeres and telomerase in cancer |
Q35131781 | Telomeres in cancer and aging: lessons from the mouse |
Q56508014 | The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability |
Q34038272 | The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. |
Q38035437 | The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems |
Q33852211 | The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. |
Q24632444 | The telomere syndromes |
Q34323827 | The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas |
Q38512280 | Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telo |
Q34993878 | Trastuzumab increases the sensitivity of HER2-amplified human gastric cancer cells to oxaliplatin and cisplatin by affecting the expression of telomere-associated proteins |
Q35920022 | Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer |
Q53212157 | Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma. |