No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells

scientific article

No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DNAREP.2008.11.009
P932PMC publication ID2663532
P698PubMed publication ID19071232

P2093author name stringLea A Harrington
Natalie Erdmann
P2860cites workA telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenitaQ24536887
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointQ24562757
Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiationQ24563808
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA.Q27640301
RPA-like proteins mediate yeast telomere functionQ27939798
Homologous recombination generates T-loop-sized deletions at human telomeresQ28116970
DNA damage-induced activation of p53 by the checkpoint kinase Chk2Q28138195
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiationQ28145356
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenitaQ28189076
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
Protein composition of catalytically active human telomerase from immortal cellsQ28295708
The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damageQ28586234
Conditional telomerase induction causes proliferation of hair follicle stem cellsQ28591715
Effects of telomerase and telomere length on epidermal stem cell behaviorQ28592564
DNA damage foci at dysfunctional telomeresQ29614811
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protectionQ33221889
Functional human telomeres are recognized as DNA damage in G2 of the cell cycleQ33227804
Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protectionQ33255919
Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpointQ33266104
Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenanceQ33290676
Telomere length homeostasisQ36495238
Telomere-related genome instability in cancer.Q36547726
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeatsQ36657077
End Resection Initiates Genomic Instability in the Absence of TelomeraseQ37062471
Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous miceQ37646957
Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.Q38331074
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.Q39120582
Different telomere damage signaling pathways in human and mouse cellsQ39647901
The nature of telomere fusion and a definition of the critical telomere length in human cellsQ40073766
Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cellsQ40272786
Telomeres and senescence: the history, the experiment, the futureQ40863958
Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutantQ42724068
Telomere dysfunction increases mutation rate and genomic instabilityQ43709760
Telomerase protects developing neurons against DNA damage-induced cell deathQ43806162
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.Q44762653
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiaeQ46062549
Engineering the end: DNA processing at human telomeresQ46443307
TERT promotes cellular and organismal survival independently of telomerase activityQ46788573
A novel mechanism for telomere size control in Saccharomyces cerevisiaeQ47331172
The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.Q52167636
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.Q53851296
Telomere dysfunction and the initiation of genome instability.Q55036686
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndromeQ73217622
Telomerase modulates expression of growth-controlling genes and enhances cell proliferationQ73322990
Functional characterization of natural telomerase mutations found in patients with hematologic disordersQ80312844
Mre 11 p nuclease activity is dispensable for telomeric rapid deletionQ81912861
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.Q33293671
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.Q33852211
Haploinsufficiency of mTR results in defects in telomere elongationQ34019216
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.Q34019245
Constitutive telomerase expression promotes mammary carcinomas in aging miceQ34031827
The effect of TERC haploinsufficiency on the inheritance of telomere lengthQ34144616
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpressionQ34166733
Telomerase contributes to tumorigenesis by a telomere length-independent mechanismQ34188701
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemiaQ34409487
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damageQ34453891
Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenitaQ34514264
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatinQ34535628
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesisQ34535672
Phosphorylation of H2AX at short telomeres in T cells and fibroblastsQ34550319
Short telomeres, even in the presence of telomerase, limit tissue renewal capacityQ34563497
Regulation of telomere elongation by the cyclin-dependent kinase CDK1.Q34572159
Telomerase RNA levels limit the telomere length equilibriumQ34578043
Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).Q34614221
Short telomeres induce a DNA damage response in Saccharomyces cerevisiaeQ34813172
Telomerase: biochemical considerations for enzyme and substrate.Q34989394
Mouse models for telomere and telomerase biologyQ35176465
Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletionQ35591723
Activation of the DNA damage response by telomere attrition: a passage to cellular senescence.Q35700998
Those dam-aged telomeres!Q35756005
Telomeres are double-strand DNA breaks hidden from DNA damage responsesQ35776499
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeresQ35837052
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenitaQ35848013
Functional links between telomeres and proteins of the DNA-damage responseQ35853775
Human cell senescence as a DNA damage response.Q35989854
Chromatin and the DNA damage responseQ36208346
Making the most of a little: dosage effects in eukaryotic telomere length maintenanceQ36245192
Chromosome healing by de novo telomere addition in Saccharomyces cerevisiaeQ36392152
The maintenance and masking of chromosome terminiQ36471960
P433issue3
P921main subjectDNA damageQ5205747
P304page(s)347-353
P577publication date2008-12-25
P1433published inDNA RepairQ3894086
P1476titleNo attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells
P478volume8

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cites work (P2860)
Q35615304Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment
Q33566461Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
Q39308305Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis
Q37833939Non-telomeric activities of telomerase.
Q35096706Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase
Q35597009Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells
Q36914679Telomeres, a busy platform for cell signaling.
Q37846533Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Q93086370Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts

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