Telomerase in the human organism

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Telomerase in the human organism is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1011765592
P356DOI10.1038/SJ.ONC.1205083
P698PubMed publication ID11850781
P5875ResearchGate publication ID11510237

P2093author name stringKathleen Collins
James R Mitchell
P2860cites workNhp2p and Nop10p are essential for the function of H/ACA snoRNPsQ22008508
Mammalian telomeres end in a large duplex loopQ22009893
Dyskerin localizes to the nucleolus and its mislocalization is unlikely to play a role in the pathogenesis of dyskeratosis congenitaQ22010777
A telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulationQ22065786
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAsQ22253860
Human telomerase contains two cooperating telomerase RNA moleculesQ24291388
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during ImmortalizationQ24310670
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functionsQ24317067
Severe growth defect in mouse cells lacking the telomerase RNA componentQ47991784
Expression of TERT in early premalignant lesions and a subset of cells in normal tissuesQ47991825
Developmental regulation of telomerase activity in human fetal tissues during gestationQ48599863
Dyskeratosis Congenita (DC) Registry: identification of new features of DC.Q50848237
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potentialQ52018513
Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.Q52165691
Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytesQ52537213
Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA componentQ52579047
Telomere end-replication problem and cell agingQ56508218
Accelerated telomere shortening in ataxia telangiectasiaQ57017468
Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using anin VivoReconstitution SystemQ63384208
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.Q64988940
Telomerase activity concentrates in the mitotically active segments of human hair folliclesQ71937963
Accelerated telomere shortening and telomerase activation in Fanconi's anaemiaQ73165209
Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunitQ73170467
Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiaeQ73297605
Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human developmentQ73670399
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocationQ73720782
Dyskeratosis and ribosomal rebellionQ74557662
Chromosomal breakage analysis in dyskeratosis congenita peripheral blood lymphocytesQ77348076
Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesionsQ78237647
Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levelsQ39551372
One-step affinity purification protocol for human telomeraseQ39724301
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activityQ40825989
Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptaseQ40848482
Telomerase activity does not always imply telomere maintenanceQ40977667
Dyskeratosis congenita: an inherited bone marrow failure syndromeQ40979710
Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomeraseQ41035726
The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere lengthQ41109914
The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigenQ41517399
Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissuesQ41841480
Telomerase is not an epidermal stem cell marker and is downregulated by calciumQ42465424
Detection of telomerase activity in malignant and nonmalignant skin conditionsQ42516900
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrowQ42528725
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferationQ42830375
Mechanism of telomerase induction during T cell activationQ44208409
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changesQ46069224
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAsQ46821624
Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhangQ47240761
Small nucleolar RNA-guided post-transcriptional modification of cellular RNAsQ24535572
Identification of two RNA-binding proteins associated with human telomerase RNAQ24548517
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10Q24551042
Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cellsQ24555109
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthaseQ27935785
RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcriptsQ27936766
Pseudouridine synthases: four families of enzymes containing a putative uridine-binding motif also conserved in dUTPases and dCTP deaminasesQ27939204
Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.Q27940038
Functional requirement of p23 and Hsp90 in telomerase complexesQ28115669
Reconstitution of human telomerase activity in vitroQ28116966
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptaseQ28138478
Secondary structure of vertebrate telomerase RNAQ28138961
Unexplained aplastic anaemia, immunodeficiency, and cerebellar hypoplasia (Hoyeraal-Hreidarsson syndrome) due to mutations in the dyskeratosis congenita gene, DKC1Q28139353
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particleQ28144506
Overlap of dyskeratosis congenita with the Hoyeraal-Hreidarsson syndromeQ28145789
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenitaQ28189076
Identification of novel DKC1 mutations in patients with dyskeratosis congenita: implications for pathophysiology and diagnosisQ28191248
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats familyQ28564535
NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteriaQ28574203
A mammalian telomerase-associated proteinQ28595030
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
A survey of telomerase activity in human cancerQ29614858
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endQ29615761
The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functionsQ29616485
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Euplotes telomerase contains an La motif protein produced by apparent translational frameshiftingQ30306373
Reversing Time: Origin of TelomeraseQ30471858
Telomere maintenance mechanisms and cellular immortalization.Q33540084
Hematopoietic stem cells and agingQ33654953
In vivotelomere dynamics of human hematopoietic stem cellsQ33726870
Telomeres and HIV diseaseQ33863067
Telomerase activity in normal and malignant hematopoietic cellsQ33883794
Dyskeratosis congenita, telomeres and human ageingQ33899420
Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biologyQ33912829
hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitroQ33938937
Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitroQ33959420
Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNAQ33959977
Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomeraseQ33966749
Mice without telomerase: what can they teach us about human cancer?Q33995041
RNA binding domain of telomerase reverse transcriptaseQ34011552
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivoQ34012762
Dyskeratosis congenita in all its formsQ34071682
Telomeres and their controlQ34090772
Telomerase and human tumorigenesisQ34136624
Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouseQ34283802
The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivoQ34363735
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytesQ34387542
Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenitaQ34514264
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequenceQ34654211
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.Q34724924
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activityQ34785876
Telomerase RNA function in recombinant Tetrahymena telomeraseQ35203518
Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferationQ35786049
The rate of telomere sequence loss in human leukocytes varies with ageQ36093340
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complexQ36199868
Telomere length dynamics and chromosomal instability in cells derived from telomerase null miceQ36255827
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytesQ36338644
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.Q36375132
Telomere lengthening and telomerase activation during human B cell differentiationQ36596432
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalizationQ36754020
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Coordinate Regulation of G- and C Strand Length during New Telomere SynthesisQ36942197
Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatusQ38306636
Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10pQ38668875
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.Q39120582
Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.Q39454500
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)564-579
P577publication date2002-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inOncogeneQ1568657
P1476titleTelomerase in the human organism
P478volume21

Reverse relations

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Q55096010The Emerging Roles for Telomerase in the Central Nervous System.
Q36931009The PUA domain - a structural and functional overview
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