Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro

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Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.19.9.6207
P932PMC publication ID84565
P698PubMed publication ID10454567

P50authorJerry W ShayQ89873929
P2093author name stringW E Wright
L P Ford
X Yi
S E Holt
M Ouellette
D L Aisner
V M Tesmer
B C Frank
P2860cites workCLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Human telomerase contains evolutionarily conserved catalytic and structural subunitsQ24604009
Ciliate telomerase RNA structural featuresQ24629436
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Functional requirement of p23 and Hsp90 in telomerase complexesQ28115669
Reconstitution of human telomerase activity in vitroQ28116966
Telomerase RNAs of different ciliates have a common secondary structure and a permuted templateQ28240524
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomasQ28258624
Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domainQ47862999
Inhibition of human telomerase activity by peptide nucleic acidsQ47960865
Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzymeQ48072977
Boundary elements of the Tetrahymena telomerase RNA template and alignment domainsQ71738168
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats familyQ28564535
A mammalian telomerase-associated proteinQ28595030
The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primersQ28776783
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisQ29614741
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' endQ29615761
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
TLC1: template RNA component of Saccharomyces cerevisiae telomeraseQ29618197
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomesQ29618293
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Self-assembly of a group I intron active site from its component tertiary structural domains.Q30463736
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallaxQ30472352
Functional Evidence for an RNA Template in TelomeraseQ33998306
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequenceQ34654211
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitroQ34655881
Functionally interacting telomerase RNAs in the yeast telomerase complexQ35194966
Telomerase RNA function in recombinant Tetrahymena telomeraseQ35203518
Specific telomerase RNA residues distant from the template are essential for telomerase functionQ35210631
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.Q35912728
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complexQ36199868
Inhibition of human telomerase by 2'-O-methyl-RNAQ36312946
The catalytic subunit of yeast telomeraseQ36558592
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Expression of mouse telomerase catalytic subunit in embryos and adult tissues.Q37470406
Architecture of telomerase RNA.Q37639292
Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanningQ38342698
One-step affinity purification protocol for human telomeraseQ39724301
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivityQ40395982
A conserved pseudoknot in telomerase RNAQ40509631
Cellular delivery of peptide nucleic acids and inhibition of human telomeraseQ40947066
Telomerase activity does not always imply telomere maintenanceQ40977667
Molecular cloning of bovine telomerase RNA.Q40988429
Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cellsQ41036325
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseQ41053498
Functional characterization and developmental regulation of mouse telomerase RNA.Q41306667
Induced folding in RNA-protein recognition: more than a simple molecular handshakeQ41698041
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferationQ42830375
A conserved secondary structure for telomerase RNAQ44060757
Runaway telomere elongation caused by telomerase RNA gene mutationsQ46144742
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitroQ46806433
Independent ligand-induced folding of the RNA-binding domain and two functionally distinct antitermination regions in the phage lambda N proteinQ47862787
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)6207-6216
P577publication date1999-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTwo inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
P478volume19

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cites work (P2860)
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