Telomere biology of human hematopoietic stem cells

scientific article published on March 2004

Telomere biology of human hematopoietic stem cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1177/107327480401100214
P698PubMed publication ID15024344

P2093author name stringNgaire Elwood
P2860cites workTankyrase, a poly(ADP-ribose) polymerase at human telomeresQ22008022
Mammalian telomeres end in a large duplex loopQ22009893
Ku binds telomeric DNA in vitroQ22010395
Normal human chromosomes have long G-rich telomeric overhangs at one endQ22065787
Identification of human Rap1: implications for telomere evolutionQ22254239
Human POT1 facilitates telomere elongation by telomeraseQ24303687
A human telomeric proteinQ24304466
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2Q24317670
Control of telomere length by the human telomeric protein TRF1Q24320111
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiationQ24596210
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA.Q27640301
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Stem cells, cancer, and cancer stem cellsQ27860878
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
Stem CellsQ28111899
Human Ku70/80 associates physically with telomerase through interaction with hTERTQ28115815
Pot1, the putative telomere end-binding protein in fission yeast and humansQ28188476
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenitaQ28189076
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
Telomeric localization of TRF2, a novel human telobox proteinQ28314941
Senescence Induced by Altered Telomere State, Not Telomere LossQ28315731
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
The serial cultivation of human diploid cell strainsQ29547356
Telomeres shorten during ageing of human fibroblastsQ29547357
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
Switching and signaling at the telomereQ29615653
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Essential role of mouse telomerase in highly proliferative organsQ29620451
Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere lossQ33183485
Differentiation of immortal cells inhibits telomerase activity.Q33670557
In vivo telomere dynamics of human hematopoietic stem cellsQ33726870
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisQ33862956
Telomerase activity in normal and malignant hematopoietic cellsQ33883794
The terminal DNA structure of mammalian chromosomesQ33886897
Cell senescence and cancerQ33957948
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsQ33962085
The telomere hypothesis of cellular agingQ33973605
The role of telomerase expression and telomere length maintenance in human and mouseQ34001044
Repair of telomeric DNA prior to replicative senescenceQ34034005
Alternative lengthening of telomeres in mammalian cellsQ34114656
Telomerase activation, cellular immortalization and cancerQ34235187
Telomere dynamics and genetic instability in disease progression of chronic myeloid leukemiaQ34293533
Telomere maintenance mechanisms as a target for drug developmentQ34293590
Telomere dynamics in myelodysplastic syndromes and acute leukemic transformationQ34431569
Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenitaQ34514264
Telomerase in the human organismQ34535632
Senescence: does it all happen at the ends?Q34535679
Telomeres and telomerase in hematologic neoplasiaQ34535734
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.Q34724924
Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure?Q35015447
Stem cells, telomerase and dyskeratosis congenitaQ35050092
Hematopoietic stem cells and hematopoiesisQ35071092
It's moving day: factors affecting peripheral blood stem cell mobilization and strategies for improvement [corrected].Q35183791
Telomeric DNA in normal and leukemic blood cellsQ35553065
The rate of telomere sequence loss in human leukocytes varies with age.Q36093340
Regulated expression of telomerase activity in human T lymphocyte development and activationQ36366852
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.Q36375132
Regulation of telomerase activity in immortal cell linesQ36560197
Telomere loss: mitotic clock or genetic time bomb?Q36706939
An overhanging 3' terminus is a conserved feature of telomeresQ36753674
Cell cycle-dependent modulation of telomerase activity in tumor cells.Q37573521
Heterogeneity in telomere length of human chromosomes.Q39426746
Telomerase, Cell Immortality, and CancerQ40431193
Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphomaQ40635344
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotypeQ40978432
Dimethyl sulfoxide (DMSO) causes a reversible inhibition of telomerase activity in a Burkitt lymphoma cell line.Q41022028
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseQ41053498
Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenesQ41326041
Human endothelial cell life extension by telomerase expressionQ41688544
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrowQ42528725
Telomere length changes in patients with aplastic anaemiaQ43572280
Normalization of previously shortened telomere length under treatment with imatinib argues against a preexisting telomere length deficit in normal hematopoietic stem cells from patients with chronic myeloid leukemiaQ44473593
Telomerase activity in hematopoietic cells is associated with self-renewal potentialQ46183315
Telomere states and cell fatesQ46830116
Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhangQ47240761
Down-regulation of telomerase activity is an early event of cellular differentiation without apparent telomeric DNA changeQ47783344
Severe growth defect in mouse cells lacking the telomerase RNA componentQ47991784
Expression of TERT in early premalignant lesions and a subset of cells in normal tissuesQ47991825
Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants.Q50910580
Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation.Q52022148
Telomere dynamics in childhood leukemia and solid tumors: a follow-up study.Q52109001
Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.Q52165691
Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy.Q52191382
Telomerase maintains telomere structure in normal human cells.Q52551445
Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression.Q53446477
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry.Q55067752
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome StabilityQ56508014
Tankyrase promotes telomere elongation in human cellsQ56969704
P433issue2
P304page(s)77-85
P577publication date2004-03-01
P1433published inCancer ControlQ15724614
P1476titleTelomere biology of human hematopoietic stem cells
P478volume11

Reverse relations

cites work (P2860)
Q40470548Acute myeloid leukemia arising from a donor derived premalignant hematopoietic clone: A possible mechanism for the origin of leukemia in donor cells.
Q41990866Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh
Q81073576Functional genomics of hTERT gene in leukemic myelopoiesis
Q40284074Human telomerase reverse transcriptase protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal
Q36274746Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions?

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