Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae

scientific article published on 01 December 1999

Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.53.38027
P698PubMed publication ID10608871

P2093author name stringC Autexier
F Bachand
P2860cites workThe telomerase reverse transcriptase: components and regulationQ22065785
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
Human telomerase contains evolutionarily conserved catalytic and structural subunitsQ24604009
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Functional requirement of p23 and Hsp90 in telomerase complexesQ28115669
Reconstitution of human telomerase activity in vitroQ28116966
Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expressionQ28131772
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expressionQ28277156
The RNA component of human telomeraseQ28288330
A mammalian telomerase-associated proteinQ28595030
A survey of telomerase activity in human cancerQ29614858
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
Reverse transcriptase motifs in the catalytic subunit of telomeraseQ29618392
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
TelomerasesQ33536623
A reassessment of the telomere hypothesis of senescenceQ33536846
Telomere maintenance mechanisms and cellular immortalization.Q33540084
Telomeres and telomerase: more than the end of the lineQ33669749
Telomerase RNA function in recombinant Tetrahymena telomeraseQ35203518
Humanizing the yeast telomerase templateQ36095862
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complexQ36199868
The catalytic subunit of yeast telomeraseQ36558592
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP).Q39720480
Telomerase and cancer: revisiting the telomere hypothesisQ41211805
Telomerase in yeastQ46265180
Functional reconstitution of wild-type and mutant Tetrahymena telomeraseQ71650294
Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in miceQ77160276
P433issue53
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)38027-38031
P577publication date1999-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleFunctional reconstitution of human telomerase expressed in Saccharomyces cerevisiae
P478volume274

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cites work (P2860)
Q41079399A human telomerase-associated nuclease
Q24817124A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation
Q36803215A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization
Q28115203A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function
Q34632410A yeast chemical genetic screen identifies inhibitors of human telomerase
Q92525197Accelerating the Production of Druggable Targets: Eukaryotic Cell-Free Systems Come into Focus
Q28116246An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization
Q35131769Biochemical aspects of telomerase function
Q34285674C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity
Q27930866Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast
Q38311742Expression of hTERT and hTR in cis reconstitutes and active human telomerase ribonucleoprotein
Q39677546Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit
Q33969441Functional multimerization of the human telomerase reverse transcriptase
Q40763366Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer
Q39458154Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
Q39097445Human telomerase RNA-protein interactions
Q24533247Human telomerase and its regulation
Q40564707Human telomerase catalyzes nucleolytic primer cleavage
Q37521080Humanized telomeres and an attempt to express a functional human telomerase in yeast
Q35626186Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT.
Q34012762N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
Q24550780Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
Q38956827Potential Risks in the Paradigm of Basic to Translational Research: A Critical Evaluation of qPCR Telomere Size Techniques.
Q40697593Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells
Q41916619Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase
Q37619880Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities
Q30437549Soluble domains of telomerase reverse transcriptase identified by high-throughput screening
Q38668875Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p
Q37464876Targeting to the endoplasmic reticulum improves the folding of recombinant human telomerase reverse transcriptase.
Q34535632Telomerase in the human organism
Q40037721Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation
Q30453860Tetrahymena proteins p80 and p95 are not core telomerase components
Q39792077The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
Q33760211The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
Q38290133The nucleolar localization domain of the catalytic subunit of human telomerase
Q34060945The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein

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