Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins

scientific article

Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MSPHERE.00234-17
P932PMC publication ID5489658
P698PubMed publication ID28680969

P50authorBenjamin BrennanQ29460007
Dong-Yan JinQ55274621
P2093author name stringRichard M Elliott
Ping Li
Vidyanath Chaudhary
Veronica V Rezelj
P2860cites workViral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platformQ24294301
Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodiesQ24312835
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1Q24318342
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responsesQ24324685
Toscana virus NSs protein inhibits the induction of type I interferon by interacting with RIG-IQ24337813
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.Q24533140
Fever with thrombocytopenia associated with a novel bunyavirus in ChinaQ24615216
Jalview Version 2--a multiple sequence alignment editor and analysis workbenchQ24655519
Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteinsQ26745530
Phleboviruses and the Type I Interferon ResponseQ26747457
Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropismQ27469650
The carboxy-terminal acidic domain of Rift Valley Fever virus NSs protein is essential for the formation of filamentous structures but not for the nuclear localization of the protein.Q27469709
The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal DegradationQ27477650
Association of the nonstructural protein NSs of Uukuniemi virus with the 40S ribosomal subunitQ27486241
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNAQ27675053
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylationQ27679261
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2Q28198356
Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5Q28202525
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virusQ28486276
Virome analysis of Amblyomma americanum, Dermacentor variabilis, and Ixodes scapularis ticks reveals novel highly divergent vertebrate and invertebrate virusesQ28655283
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasuresQ29615028
Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potentialQ30417679
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.Q33198557
A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.Q33316823
Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcomeQ33398602
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse modelQ33401592
Cytokine and chemokine levels in patients with severe fever with thrombocytopenia syndrome virusQ33402913
A new phlebovirus associated with severe febrile illness in Missouri.Q33403011
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
The genome sequence of Lone Star virus, a highly divergent bunyavirus found in the Amblyomma americanum tickQ33407455
Novel bunyavirus in domestic and captive farmed animals, Minnesota, USAQ33409925
Severe fever with thrombocytopenia syndrome, South Korea, 2012.Q33411350
The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in JapanQ33411464
Malsoor virus, a novel bat phlebovirus, is closely related to severe fever with thrombocytopenia syndrome virus and heartland virusQ33412477
Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virusQ33413705
Heartland virus-associated death in tennesseeQ33415866
Reverse genetics system for severe fever with thrombocytopenia syndrome virusQ33419562
Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodiesQ33420049
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonistQ33420335
Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activationQ33425728
Novel phleboviruses detected in ticks, Greece.Q33430447
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndromeQ33438392
Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1Q33641410
Emerging phlebovirusesQ33652514
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor proteinQ33939684
Tick-borne viruses in EuropeQ34270315
Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesisQ34625091
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon.Q35000433
The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packagingQ35097103
Inhibitors of the interferon response enhance virus replication in vitro.Q35414495
A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulenceQ35616459
Flexibility of bunyavirus genomes: creation of an orthobunyavirus with an ambisense S segmentQ35641541
Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanismsQ35831317
Double-Stranded RNA Is Detected by Immunofluorescence Analysis in RNA and DNA Virus Infections, Including Those by Negative-Stranded RNA VirusesQ35973655
Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.Q36501737
Dicer-2- and Piwi-mediated RNA interference in Rift Valley fever virus-infected mosquito cellsQ36559849
Antiviral signaling through pattern recognition receptorsQ36693188
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.Q36742231
Toscana virus NSs protein promotes degradation of double-stranded RNA-dependent protein kinaseQ36759758
STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitisQ37239746
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseasesQ37414046
Orthobunyaviruses: recent genetic and structural insightsQ38246823
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIHQ38326807
STAT1 is inactivated by a caspaseQ38337795
NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKRQ38774860
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
Viperin, MTAP44, and protein kinase R contribute to the interferon-induced inhibition of Bunyamwera Orthobunyavirus replicationQ39296817
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSsQ39601913
Novel cross-talk within the IKK family controls innate immunityQ39622962
Toscana virus induces interferon although its NSs protein reveals antagonistic activityQ39652674
Oligomerization of Uukuniemi virus nucleocapsid proteinQ39669040
Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteinsQ39699288
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activationQ39869345
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switchQ40127834
Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activationQ40298486
STAT2 nuclear traffickingQ40549587
Identification of a major non-structural protein in the nuclei of Rift Valley fever virus-infected cellsQ40844168
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).Q41186845
Analysis Tool Web Services from the EMBL-EBI.Q42265365
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA virusesQ42425012
Hunter Island Group Phlebovirus in Ticks, AustraliaQ42723743
ISOLATION OF SOME VIRUSES OTHER THAN TYPICAL TICK-BORNE ENCEPHALITIS VIRUSES FROM IXODES RICINUS TICKS IN FINLAND.Q42979455
Arboviruses in Finland. 3. Uukuniemi virus antibodies in human, cattle, and reindeer seraQ44630173
Mitochondrial membrane potential is required for MAVS-mediated antiviral signalingQ45285051
Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in miceQ45350991
Passerine birds in the ecology of Uukuniemi virusQ45814830
Uukuniemi virus in small rodentsQ45817259
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.Q52182764
Correction: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient miceQ86969316
P433issue3
P577publication date2017-05-01
P1433published inmSphereQ27727104
P1476titleDifferential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins
P478volume2

Reverse relations

cites work (P2860)
Q55209368A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.
Q52808425Control of Lyme borreliosis and other Ixodes ricinus-borne diseases.
Q91824345Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model
Q90229101Immune Modulation and Immune-Mediated Pathogenesis of Emerging Tickborne Banyangviruses
Q59352330NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
Q91983849Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs
Q56561912Two conserved amino acids within the NSs of SFTS phlebovirus are essential for anti-interferon activity
Q97519293eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

Search more.