NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR

scientific article published on 27 April 2016

NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00016-16
P932PMC publication ID4907219
P698PubMed publication ID27122577

P50authorVeit HornungQ16295222
Friedemann WeberQ40182480
P2093author name stringCharles E Samuel
Markus Kainulainen
Simone Lau
P2860cites workViral immune modulators perturb the human molecular network by common and unique strategiesQ24293704
Antiviral actions of interferonsQ24550676
Synthesis of an arrayed sgRNA library targeting the human genome.Q40455231
A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB.Q42075805
SUnSET, a nonradioactive method to monitor protein synthesis.Q51755635
SnapShot: F box proteins IQ84067256
SnapShot: F Box Proteins IIQ84140569
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The NSm proteins of Rift Valley fever virus are dispensable for maturation, replication and infectionQ27485926
Interferon-inducible antiviral effectorsQ27486790
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitinationQ28143145
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.Q33198557
A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.Q33316823
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
Recent outbreaks of rift valley Fever in East Africa and the middle EastQ34292066
Interferon-stimulated genes: a complex web of host defensesQ34405609
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.Q34536954
Deletion of the NSm virulence gene of Rift Valley fever virus inhibits virus replication in and dissemination from the midgut of Aedes aegypti mosquitoesQ35097798
A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulenceQ35616459
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replicationQ35801885
Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 LigaseQ35912398
Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cellsQ35947659
NSm protein of Rift Valley fever virus suppresses virus-induced apoptosisQ36315241
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammationQ36781352
Mechanisms and function of substrate recruitment by F-box proteins.Q37307464
The risk of Rift Valley fever virus introduction and establishment in the United States and European UnionQ37433782
Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cellsQ37522386
Relevance of Rift Valley fever to public health in the European UnionQ38091739
Protein kinase R and the inflammasome.Q38218189
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIHQ38326807
Interplay between the Virus and Host in Rift Valley Fever PathogenesisQ38376184
OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell linesQ38960087
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.Q39547955
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSsQ39601913
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcriptionQ39960501
Potential vectors of Rift Valley fever virus in the Mediterranean regionQ40414505
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectRift Valley feverQ326638
Rift Valley fever virusQ14276794
Rift Valley fever phlebovirusQ24809101
P304page(s)6140-6147
P577publication date2016-04-27
P1433published inJournal of VirologyQ1251128
P1476titleNSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR
P478volume90

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cites work (P2860)
Q59335452A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice
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Q37628197Attacked from All Sides: RNA Decay in Antiviral Defense
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Q33443358Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins
Q64097373Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)
Q89828861Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma
Q33442499Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses
Q28554535Mechanistic Insight into the Host Transcription Inhibition Function of Rift Valley Fever Virus NSs and Its Importance in Virulence
Q59352330NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
Q26747457Phleboviruses and the Type I Interferon Response
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Q55313404The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus.
Q91800766Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

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