Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

scientific article published in 2019

Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00668-19
P932PMC publication ID6479006
P698PubMed publication ID31015330

P2093author name stringKatherine R Spindler
Carla D Pretto
Kelly E Carnahan
Danielle E Goodman
Tomas A Krepostman
P2860cites workMolecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferonQ24301655
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substratesQ24337261
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinaseQ24338183
Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machineryQ24538586
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysisQ24621105
Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitinationQ27932737
HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanismsQ28141850
Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinaseQ28186486
Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infectionQ28265093
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKRQ28284542
The ImageJ ecosystem: An open platform for biomedical image analysisQ28364366
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexQ29041391
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinaseQ29620280
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.Q33785225
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus.Q33811639
Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 proteinQ33827148
dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.Q33843219
Polyribosome analysis for investigating mRNA translation in Xenopus oocytes, eggs and embryosQ33843716
Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2Q33961613
Distribution of mouse adenovirus type 1 in intraperitoneally and intranasally infected adult outbred mice.Q34069512
Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesisQ34236342
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.Q34337534
Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 miceQ34458051
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.Q34466906
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signalingQ34648134
Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditisQ34992644
Virus-associated RNAs of naturally occurring strains and variants of group C adenovirusesQ35238178
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKRQ35273064
A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesityQ35629493
Proteasomes and protein conjugation across domains of lifeQ35792807
Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectivesQ35836881
Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c miceQ35852023
Structure, function, and evolution of adenovirus-associated RNA: a phylogenetic approach.Q35865863
Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 LigaseQ35912398
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesQ36175026
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradationQ36359536
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infectionQ36432681
Processing of Adenovirus 2-Induced ProteinsQ36592083
Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNAQ36641030
The kinase activity of PKR represses inflammasome activityQ36665763
Toscana virus NSs protein promotes degradation of double-stranded RNA-dependent protein kinaseQ36759758
Adenovirus virus-associated RNA and translation controlQ36820396
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.Q36827533
Identification of the gene coding for the precursor of adenovirus core protein X.Q36867210
The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1γ sumoylation and poly-SUMO chain elongationQ37021805
Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of AdenovirusesQ37174450
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53Q37194715
Genetic analysis of adenovirus type 2 III. Temperature sensitivity of processing viral proteinsQ37499336
MG132, a proteasome inhibitor, induces apoptosis in tumor cellsQ38035077
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinaseQ38318400
Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replicationQ38698634
NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKRQ38774860
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infectionQ39421013
CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic ProteinsQ39866921
Susceptibility and signs associated with mouse adenovirus type 1 infection of adult outbred Swiss mice.Q39872819
Herpes simplex virus type 1 immediate-early gene expression is required for the induction of apoptosis in human epithelial HEp-2 cellsQ40377056
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomibQ40431708
Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replicationQ40643752
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infectionQ40863327
Interaction of mouse adenovirus type 1 early region 1A protein with cellular proteins pRb and p107.Q41163414
Endogenous inhibitors of the dsRNA-dependent eIF-2 alpha protein kinase PKR in normal and ras-transformed cellsQ41503444
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.Q41831125
Mouse adenovirus type 1 infection of macrophagesQ42559283
Transcription mapping of mouse adenovirus type 1 early region 4Q42603302
DQ-Red BSA Trafficking Assay in Cultured Cells to Assess Cargo Delivery to LysosomesQ42626004
The proteinase polypeptide of adenovirus serotype 2 virionsQ42633165
Completion of the DNA sequence of mouse adenovirus type 1: sequence of E2B, L1, and L2 (18-51 map units).Q42668152
Adenovirus myocarditis in mice. An electron microscopic studyQ43744360
Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinaseQ44081848
Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinaseQ44539835
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factorQ45772727
Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.Q45779943
Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infectionsQ45847989
Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes.Q45949957
RNA of low molecular weight in KB cells infected with adenovirus type 2.Q47411998
Role of eIF2α Kinases in Translational Control and Adaptation to Cellular StressQ50027676
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.Q52116428
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.Q52533947
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.Q54092575
Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review.Q54979942
Construction of mouse adenovirus type 1 mutantsQ64377183
Novel expression of mouse adenovirus type 1 early region 3 gp11K at late times after infectionQ64381459
Autophosphorylation of the protein kinase dependent on double-stranded RNAQ68778559
The double-stranded RNA-dependent protein kinase is also activated by heparinQ69397069
A study of the mechanisms of cytotoxicity of Ara-C on three human leukemic cell linesQ69664200
Inhibitors of DNA synthesis (aphidicolin and araC/HU) prevent the recovery of RNA synthesis after UV-irradiationQ72736961
Inhibition of protein synthesis in reticulocytes by antibiotics. II. The site of action of cycloheximide, streptovitacin A and pactamycinQ72905294
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
proteasome complexQ14878333
P577publication date2019-04-23
P1433published inmBioQ15817061
P1476titleEnhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)
P478volume10

Reverse relations

cites work (P2860)
Q103762211Porcine circovirus type 2 exploits cap to inhibit PKR activation through interaction with Hsp40
Q91775774The Leader Protein of Theiler's Virus Prevents the Activation of PKR

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