SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

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SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.5684S
P356DOI10.1371/JOURNAL.PONE.0005684
P932PMC publication ID2683566
P698PubMed publication ID19492079
P5875ResearchGate publication ID26262611

P50authorAgnete LarsenQ73493034
Nils Erik MagnussonQ74248891
Ashley I. BushQ39880503
Niels JessenQ41440737
P2093author name stringJørgen Rungby
Meredin Stoltenberg
Ole Schmitz
Kamille Smidt
Birgitte Brock
Lise Wogensen
Janetta G Culvenor
Andrew Tsatsanis
Andreas Brønden Petersen
Johanne Bruun Jeppesen
P2860cites workSurvey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains.Q52165714
Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.Q53499112
Effect of diethyldithiocarbamate on diabetogenic action of alloxan in ratsQ72964860
Zinc and Alzheimer's disease: is there a direct link?Q73369561
Diabetogenic action of organic reagents: destructive lesions of islets of Langerhans caused by sodium diethyldithiocarbamate and potassium ethylxanthateQ75895515
Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obeseQ79374062
In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expressionQ21093378
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cellsQ24292494
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granulesQ24301974
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretionQ24303979
ZnT-3, a putative transporter of zinc into synaptic vesiclesQ24336868
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic miceQ24530682
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 geneQ24671498
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesQ24675521
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death programQ28190664
ZnT-8, a pancreatic beta-cell-specific zinc transporterQ28271963
A genome-wide association study identifies novel risk loci for type 2 diabetesQ28287727
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesQ28680760
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsQ29547214
The biochemical basis of zinc physiologyQ29615320
Zinc as a paracrine effector in pancreatic islet cell deathQ31399262
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetesQ33187996
Mammalian zinc transport, trafficking, and signalsQ33997055
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. studyQ34739104
A role for zinc in cerebellar synaptic transmission?Q36328447
Silver enhancement of quantum dots resulting from (1) metabolism of toxic metals in animals and humans, (2) in vivo, in vitro and immersion created zinc-sulphur/zinc-selenium nanocrystals, (3) metal ions liberated from metal implants and particlesQ36584113
Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkeyQ36829003
Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasisQ37569576
Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cellsQ40097777
Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in miceQ40145757
Real-time PCR: housekeeping genes in the INS-1E beta-cell lineQ40316562
Zinc fluxes during acute and chronic exposure of INS-1E cells to increasing glucose levelsQ40436322
Zinc, insulin and diabetesQ41742276
The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channelQ42489171
Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.Q43502978
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.Q44364388
Zinc ions in beta-cells of obese, insulin-resistant, and type 2 diabetic rats traced by autometallographyQ44695031
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brainQ44697391
Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon releaseQ46513286
Histochemical demonstration of heavy metals. A revised version of the sulphide silver method suitable for both light and electronmicroscopyQ46525239
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiencyQ46940568
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
preproinsulinQ7240673
P304page(s)e5684
P577publication date2009-05-25
P1433published inPLOS OneQ564954
P1476titleSLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress
P478volume4

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