Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

scientific article

Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1025245856
P356DOI10.1186/1745-6150-4-19
P932PMC publication ID2701414
P698PubMed publication ID19493340
P5875ResearchGate publication ID26263776

P50authorEugene KooninQ3699974
Yuri WolfQ59640168
Kira MakarovaQ63964276
P2860cites workBacterial toxin-antitoxin systems: more than selfish entities?Q21145003
RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotesQ21184115
New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay systemQ21194875
The COG database: an updated version includes eukaryotesQ21284294
Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilumQ22066214
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperoneQ24295270
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1Q24337678
STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a geneQ24523893
Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operonQ24531777
Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factorsQ24550747
Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolutionQ24555229
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotesQ24556626
Mini-F plasmid genes that couple host cell division to plasmid proliferationQ24594938
An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell deathQ24607301
PIN domains in nonsense-mediated mRNA decay and RNAiQ47069110
Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA).Q47879002
Analysis of sequences flanking the vap regions of Dichelobacter nodosus: evidence for multiple integration events, a killer system, and a new genetic elementQ48054553
Crystal structure of the central and C-terminal domain of the sigma(54)-activator ZraR.Q50089032
PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans.Q52550949
Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome.Q54453528
Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins.Q54541820
The major birch pollen allergen, Bet v 1, shows ribonuclease activityQ71439964
Properties of the defective phage of Bacillus subtilisQ93832706
MUSCLE: multiple sequence alignment with high accuracy and high throughputQ24613456
The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pairQ24646292
Chromosomal toxin-antitoxin systems may act as antiaddiction modulesQ24646891
Small toxic proteins and the antisense RNAs that repress themQ24650967
Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipBQ24651429
Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic worldQ24653367
An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxinQ24674628
Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensisQ24675383
What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome?Q24675694
Hypothetical functions of toxin-antitoxin systemsQ24675719
Identification of a new family of putative PD-(D/E)XK nucleases with unusual phylogenomic distribution and a new type of the active siteQ24797046
Identification of novel restriction endonuclease-like fold families among hypothetical proteinsQ24811792
Crystal structure of MtaN, a global multidrug transporter gene activatorQ27635122
The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: structure, sequence analyses, and solution studiesQ27640180
Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylationQ27640314
Structural insight into the self-sacrifice mechanism of enediyne resistanceQ27643304
The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA bindingQ27655580
The PSIPRED protein structure prediction serverQ27860953
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrestQ28206549
Resistance to enediyne antitumor antibiotics by CalC self-sacrificeQ28206556
RNA antitoxinsQ28294158
Structure and functions of the GNAT superfamily of acetyltransferasesQ28296840
Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistanceQ28485657
The antibiotic resistome: the nexus of chemical and genetic diversityQ29544028
Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinementsQ29614394
Prokaryotic toxin-antitoxin stress response lociQ29615335
CDD: a database of conserved domain alignments with links to domain three-dimensional structureQ29616047
Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamily.Q30328049
Biophysical and structural property of the putative DNA-binding protein, BldB, from Streptomyces lividans.Q30333116
DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary historyQ30559537
Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmidQ30695976
The IrrE protein of Deinococcus radiodurans R1 is a novel regulator of recA expressionQ30717114
Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell.Q30738900
Who's your neighbor? New computational approaches for functional genomicsQ30874386
ATGC: a database of orthologous genes from closely related prokaryotic genomes and a research platform for microevolution of prokaryotesQ37202503
One-component systems dominate signal transduction in prokaryotesQ37372967
A global role for Fis in the transcriptional control of metabolism and type III secretion in Salmonella enterica serovar Typhimurium.Q38338833
The tripartite immunity system of phages P1 and P7Q38573820
Structure and regulation of the lytic replicon of phage P1.Q40262655
Structural features of a superfamily of zinc-endopeptidases: the metzincinsQ40428339
Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions.Q40883451
A conserved anti-repressor controls horizontal gene transfer by proteolysis.Q41851819
Regulation of NAD synthesis by the trifunctional NadR protein of Salmonella enterica.Q42216077
Identification of additional genes belonging to the LexA regulon in Escherichia coliQ42486422
Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010.Q42644411
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteinsQ44863619
Delayed-relaxed response explained by hyperactivation of RelE.Q44959788
BzdR, a repressor that controls the anaerobic catabolism of benzoate in Azoarcus sp. CIB, is the first member of a new subfamily of transcriptional regulatorsQ45213283
The radiation responsive promoter of the Deinococcus radiodurans pprA geneQ46734651
Guilt by association: contextual information in genome analysisQ30910657
Potential genomic determinants of hyperthermophilyQ33186645
The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteriaQ33253277
Multidrug tolerance of biofilms and persister cellsQ33331522
Automated discovery and phylogenetic analysis of new toxin-antitoxin systemsQ33346642
Trends in prokaryotic evolution revealed by comparison of closely related bacterial and archaeal genomesQ33382015
The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibioticsQ33393805
The bldB gene encodes a small protein required for morphogenesis, antibiotic production, and catabolite control in Streptomyces coelicolorQ33727025
MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coliQ33973437
Prediction of protein function and pathways in the genome era.Q33977658
MazF, an mRNA interferase, mediates programmed cell death during multicellular Myxococcus developmentQ34009374
HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaeaQ34015031
RNA decay by messenger RNA interferases.Q34015736
mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systemsQ34016120
Programmed death in bacteriaQ34023671
HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteinsQ34199686
Scaling laws in the functional content of genomesQ34228161
Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)Q34233333
The PIN-domain toxin-antitoxin array in mycobacteriaQ34430557
Comparison of archaeal and bacterial genomes: computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaeaQ34447405
Toxin-antitoxin modules as bacterial metabolic stress managersQ34463800
Overexpression of the LexA-regulated tisAB RNA in E. coli inhibits SOS functions; implications for regulation of the SOS responseQ34844033
Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiationQ34922870
Bacterial persistence: some new insights into an old phenomenonQ34932825
Defining the mobilomeQ34959127
The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistanceQ35164001
The MerR family of transcriptional regulators.Q35164005
Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coliQ35220633
Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococciQ35576011
The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2.Q35759454
Genetic control of bacterial suicide: regulation of the induction of PBSX in Bacillus subtilisQ35975310
Cloning and nucleotide sequence of the Bacillus subtilis ansR gene, which encodes a repressor of the ans operon coding for L-asparaginase and L-aspartaseQ36099166
Phage abortive infection in lactococci: variations on a themeQ36175317
Mobile genetic elements: the agents of open source evolutionQ36247081
P407language of work or nameEnglishQ1860
P921main subjectprokaryotesQ19081
P304page(s)19
P577publication date2009-06-03
P1433published inBiology DirectQ1954915
P1476titleComprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes
P478volume4

Reverse relations

cites work (P2860)
Q92610014A Novel Cyanobacterium Synechococcus elongatus PCC 11802 has Distinct Genomic and Metabolomic Characteristics Compared to its Neighbor PCC 11801
Q59329242A Strain of an Emerging Indian pv. oryzae Pathotype Defeats the Rice Bacterial Blight Resistance Gene Without Inducing a Clade III Gene and Is Nearly Identical to a Recent Thai Isolate
Q55056329A Toxin-Antitoxin System VapBC15 from Synechocystis sp. PCC 6803 Shows Distinct Regulatory Features.
Q37043052A bird's-eye view of autophagy.
Q34475110A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity
Q92603233A competence-regulated toxin-antitoxin system in Haemophilus influenzae
Q41908117A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida
Q27666599A processed noncoding RNA regulates an altruistic bacterial antiviral system
Q50901237A regulatory role for Staphylococcus aureus toxin-antitoxin system PemIKSa
Q34779533A simple and efficient method to search for selected primary transcripts: non-coding and antisense RNAs in the human pathogen Enterococcus faecalis
Q34172436A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance
Q34012810A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress.
Q35079828A toxin-antitoxin module of Salmonella promotes virulence in mice
Q26864700A virocentric perspective on the evolution of life
Q29346578A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism.
Q37049890AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea
Q36239815ATGC database and ATGC-COGs: an updated resource for micro- and macro-evolutionary studies of prokaryotic genomes and protein family annotation
Q24633108Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families
Q63370369An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
Q30570507Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level
Q40636250Analysis of defence systems and a conjugative IncP-1 plasmid in the marine polyaromatic hydrocarbons-degrading bacterium Cycloclasticus sp. 78-ME.
Q28487422Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis
Q34517748Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question
Q48336528AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet
Q30633115Babela massiliensis, a representative of a widespread bacterial phylum with unusual adaptations to parasitism in amoebae
Q28657639Bacterial genome instability
Q40410525Biology of archaea from a novel family Cuniculiplasmataceae (Thermoplasmata) ubiquitous in hyperacidic environments.
Q36961416Biosafety of biotechnologically important microalgae: intrinsic suicide switch implementation in cyanobacterium Synechocystis sp. PCC 6803.
Q34529451C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Q37079803CRISPR-Cas: evolution of an RNA-based adaptive immunity system in prokaryotes
Q62029120CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology
Q41908237Cell growth inhibition upon deletion of four toxin-antitoxin loci from the megaplasmids of Sinorhizobium meliloti.
Q36590715Characterization of MazF-Mediated Sequence-Specific RNA Cleavage in Pseudomonas putida Using Massive Parallel Sequencing
Q34552278Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin
Q34602278Characterization of a chromosomal type II toxin-antitoxin system mazEaFa in the Cyanobacterium Anabaena sp. PCC 7120.
Q37132897Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli
Q38002913Chromosomal bacterial type II toxin-antitoxin systems
Q38243813Chromosomal islands of Streptococcus pyogenes and related streptococci: molecular switches for survival and virulence
Q35328032Classification of prokaryotic genetic replicators: between selfishness and altruism
Q92296919Coherence of Microcystis species revealed through population genomics
Q37639631Commentary: What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence?
Q26829917Comparative genomics of defense systems in archaea and bacteria
Q30549619Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes
Q34773696Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing
Q33878209Comprehensive classification of the PIN domain-like superfamily
Q21092447Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution
Q91386159Coordination of cohabiting phage elements supports bacteria-phage cooperation
Q36206456Coupling immunity and programmed cell suicide in prokaryotes: Life-or-death choices
Q27675281Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly
Q30396012Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response
Q90622032Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus
Q41880848Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae.
Q30365589Dark matter in archaeal genomes: a rich source of novel mobile elements, defense systems and secretory complexes.
Q35362577Defense islands in bacterial and archaeal genomes and prediction of novel defense systems
Q41124460Deinococcus radiodurans Toxin-Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress
Q40394249Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning.
Q41932179Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes
Q42836520Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families
Q40142398Diversity, Prevalence, and Longitudinal Occurrence of Type II Toxin-Antitoxin Systems of Pseudomonas aeruginosa Infecting Cystic Fibrosis Lungs
Q37635836Doc toxin is a kinase that inactivates elongation factor Tu
Q46245940Draft genome sequence of Actinotignum schaalii DSM 15541T: Genetic insights into the lifestyle, cell fitness and virulence
Q26744373Emerging Roles of Toxin-Antitoxin Modules in Bacterial Pathogenesis
Q33884746Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance
Q56536937Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota
Q59520455Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle
Q93025050Evidence of nitrite acting as a stable and robust inducer of non-cultivability in Mycobacterium tuberculosis with physiological relevance
Q29616645Evolution and classification of the CRISPR-Cas systems
Q31095701Evolution of microbes and viruses: a paradigm shift in evolutionary biology?
Q39402483Evolutionary Genomics of Defense Systems in Archaea and Bacteria
Q90703899Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire
Q91916018Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity
Q35604307Expression of the Streptococcus pneumoniae yoeB chromosomal toxin gene causes cell death in the model plant Arabidopsis thaliana
Q55603379Expression, purification, and functional analysis of novel RelE operon from X. nematophila.
Q42736188Fic Proteins of Campylobacter fetus subsp. venerealis Form a Network of Functional Toxin-Antitoxin Systems
Q37522465Functional Studies of Five Toxin-Antitoxin Modules in Mycobacterium tuberculosis H37Rv
Q38433531Functional annotation of a novel toxin-antitoxin system Xn-RelT of Xenorhabdus nematophila; a combined in silico and in vitro approach.
Q34637800Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon
Q38285507Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae
Q92375928Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus
Q24618137Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions
Q58725541Genomic characterization of three novel Basilisk-like phages infecting Bacillus anthracis
Q22065946Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon
Q39167588Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes.
Q89891233Highly-regulated, diversifying NTP-based biological conflict systems with implications for emergence of multicellularity
Q38328738Homology modeling and assigned functional annotation of an uncharacterized antitoxin protein from Streptomyces xinghaiensis
Q39614246Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis
Q36970914Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii
Q36106863Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes.
Q39181653Identification of a VapBC toxin-antitoxin system in a thermophilic bacterium Thermus thermophilus HB27.
Q42677519Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus
Q34202798Identification of the first functional toxin-antitoxin system in Streptomyces
Q35212982Immunity, suicide or both? Ecological determinants for the combined evolution of anti-pathogen defense systems
Q21560741Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids
Q24605823Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems
Q34551249Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin.
Q43126277Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module
Q41962260Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity
Q41849114Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution
Q34476617Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes
Q37270749Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling
Q37036789Massive activation of archaeal defense genes during viral infection
Q42660067Metagenomic binning of a marine sponge microbiome reveals unity in defense but metabolic specialization
Q47715485Microbial genome analysis: the COG approach
Q47687116Mobile Genetic Elements and Evolution of CRISPR-Cas Systems: All the Way There and Back
Q92277945Modulation of Toxin-Antitoxin System Rnl AB Type II in Phage-Resistant Gammaproteobacteria Surviving Photodynamic Treatment
Q27677279Molecular Structure and Function of the Novel BrnT/BrnA Toxin-Antitoxin System of Brucella abortus
Q33651182MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440.
Q37670036Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.
Q34637739Multitasking SecB chaperones in bacteria
Q61800874Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair
Q42190217Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis
Q64056373Origins and evolution of CRISPR-Cas systems
Q35131534Orphan toxin OrtT (YdcX) of Escherichia coli reduces growth during the stringent response.
Q33617829Part II: defining and quantifying individual and co-cultured intracellular proteomes of two thermophilic microorganisms by GeLC-MS2 and spectral counting
Q41077972Persistence and resistance as complementary bacterial adaptations to antibiotics.
Q26748708Persisters-as elusive as ever
Q42228683Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains
Q42291199Physical and Functional Interplay between MazF1Bif and Its Noncognate Antitoxins from Bifidobacterium longum
Q58700284Physical foundations of biological complexity
Q35048912Plasmids of carotenoid-producing Paracoccus spp. (Alphaproteobacteria) - structure, diversity and evolution
Q36385479Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements
Q38187662Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems
Q100512390Predicting toxins found in toxin-antitoxin systems with a role in host-induced Burkholderia pseudomallei persistence
Q46624547Prediction of Type II Toxin-Antitoxin Loci in Klebsiella pneumoniae Genome Sequences
Q30490196Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
Q36985196Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolated Shigella flexneri VapC toxin
Q35006997Purification, crystallization and preliminary crystallographic analysis of DR0248, an MNT-HEPN fused protein from Deinococcus radiodurans
Q44235703Radiation response in Deinococcus deserti: IrrE is a metalloprotease that cleaves repressor protein DdrO.
Q100958583Rapid growth inhibitory activity of a YafQ-family endonuclease toxin of the Helicobacter pylori tfs4 integrative and conjugative element
Q34495366Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death
Q36334600Reconstruction of the evolution of microbial defense systems
Q37576199Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs
Q42207351Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking
Q30495567Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence
Q36791548Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis
Q40081460Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.
Q39539664Spontaneously induced prophages in Lactobacillus gasseri contribute to horizontal gene transfer
Q39601392Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT
Q27667500Structural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)
Q57454259Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle mycobacterial adaptation
Q28079157Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems
Q51146567Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin
Q35156594Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module
Q36636429TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin-antitoxin systems controlled by SecB-like chaperones.
Q47652216TADB 2.0: an updated database of bacterial type II toxin-antitoxin loci
Q24608697TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea
Q64090123TASmania: A bacterial Toxin-Antitoxin Systems database
Q33541401The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair
Q30364957The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium.
Q41656608The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.
Q38134377The TetR family of regulators
Q59798224The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in
Q41434064The Yersinia pestis chromosome encodes active addiction toxins
Q28485482The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system
Q36151541The ecology of bacterial genes and the survival of the new
Q48027405The endobacterium of an arbuscular mycorrhizal fungus modulates the expression of its toxin-antitoxin systems during the life cycle of its host
Q54225705The higBA Toxin-Antitoxin Module From the Opportunistic Pathogen Acinetobacter baumannii - Regulation, Activity, and Evolution.
Q28296787The phage-host arms race: shaping the evolution of microbes
Q54353124The proteolytic activation of the relNEs (ssr1114/slr0664) toxin-antitoxin system by both proteases Lons and ClpP2s/Xs of Synechocystis sp. PCC 6803.
Q33619338The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates
Q35177940The role of ribonucleases in regulating global mRNA levels in the model organism Thermus thermophilus HB8.
Q48120210The structure and function of Mycobacterium tuberculosis MazF-mt6 toxin provide insights into conserved features of MazF endonucleases
Q93066662The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics
Q57666117The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: Characterization and association to their DNA target
Q26865951To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems
Q64231626Towards functional characterization of archaeal genomic dark matter
Q36111629Toxin YafQ Reduces Escherichia coli Growth at Low Temperatures
Q33558196Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding
Q26740544Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways
Q26742021Toxin-Antitoxin Systems in Clinical Pathogens
Q40125628Toxin-Antitoxin Systems in Estuarine Synechococcus Strain CB0101 and Their Transcriptomic Responses to Environmental Stressors
Q35247925Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus
Q38064401Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many.
Q38071667Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate
Q37576197Toxin-antitoxin systems as multilevel interaction systems
Q35407636Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans
Q41462811Toxin-antitoxin systems on the large defense plasmid pSYSA of Synechocystis sp. PCC 6803.
Q39248956Toxins of Prokaryotic Toxin-Antitoxin Systems with Sequence-Specific Endoribonuclease Activity
Q37912155Toxins-antitoxins: diversity, evolution and function
Q39128063Transcriptional Profiling of Type II Toxin-Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967-HP0968 System
Q35049212Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803.
Q34596033Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli.
Q36235485Transient Duplication-Dependent Divergence and Horizontal Transfer Underlie the Evolutionary Dynamics of Bacterial Cell-Cell Signaling
Q44379430TubercuList--10 years after
Q34954571Txe, an endoribonuclease of the enterococcal Axe–Txe toxin–antitoxin system, cleaves mRNA and inhibits protein synthesis
Q39562676Type II Toxin-Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803.
Q92607847Type II Toxin-Antitoxin Systems: Evolution and Revolutions
Q26776441Type II toxin: antitoxin systems. More than small selfish entities?
Q33960829Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
Q58782384VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity
Q39534053VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus
Q33715961Virulence factors of the oral spirochete Treponema denticola
Q35500477Virus-host arms race at the joint origin of multicellularity and programmed cell death
Q26739260Viruses and mobile elements as drivers of evolutionary transitions
Q34474564Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity
Q42283159Why so narrow: Distribution of anti-sense regulated, type I toxin-antitoxin systems compared with type II and type III systems
Q34022832parD toxin-antitoxin system of plasmid R1--basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems.
Q38237093sRNA antitoxins: more than one way to repress a toxin

Search more.