Failure to replicate a genetic association may provide important clues about genetic architecture

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Failure to replicate a genetic association may provide important clues about genetic architecture is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.5639G
P356DOI10.1371/JOURNAL.PONE.0005639
P932PMC publication ID2685469
P698PubMed publication ID19503614
P5875ResearchGate publication ID26273532

P50authorJason H. MooreQ6162630
Casey S. GreeneQ41047284
Scott M WilliamsQ47430724
P2093author name stringNadia M Penrod
P2860cites workAssociation of genetic loci: replication or not, that is the questionQ44533844
'Racial' differences in genetic effects for complex diseasesQ44586727
Warfarin dose related to apolipoprotein E (APOE) genotypeQ46542560
Apolipoprotein E (APOE) and warfarin dosing in an Italian populationQ46679463
Epistasis and balanced polymorphism influencing complex trait variationQ48139307
Epistasis: too often neglected in complex trait studies?Q48541812
APOE genotype makes a small contribution to warfarin dose requirements.Q53252703
Genome-wide strategies for detecting multiple loci that influence complex diseases.Q53624440
Problems with Genome-Wide Association StudiesQ59192517
Apolipoprotein E genotype and warfarin dosing among Caucasians and African AmericansQ61850135
Problems with genome-wide association studiesQ80554408
A comprehensive review of genetic association studiesQ22337119
Estimation of the multiple testing burden for genomewide association studies of nearly all common variantsQ29614917
Replicating genotype-phenotype associationsQ29614919
Genome-wide association studies for common diseases and complex traitsQ29615822
The genetic association databaseQ29617244
Two-stage two-locus models in genome-wide associationQ33258470
Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmissionQ33389202
The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association StudiesQ33440652
Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies.Q33810312
How to interpret a genome-wide association studyQ34010528
Genome-wide association studies: theoretical and practical concernsQ34555195
The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human DiseasesQ35582337
Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesisQ36126271
On the replication of genetic associations: timing can be everything!Q36719042
Non-replication and inconsistency in the genome-wide association settingQ36841272
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasisQ37018913
Systematic biological prioritization after a genome-wide association study: an application to nicotine dependenceQ37029791
Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseasesQ37190495
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e5639
P577publication date2009-06-02
P1433published inPLOS OneQ564954
P1476titleFailure to replicate a genetic association may provide important clues about genetic architecture
P478volume4

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