Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells

scientific article published on 10 August 2009

Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00140-09
P932PMC publication ID2747925
P698PubMed publication ID19667049

P50authorMikio ShojiQ42840335
Mariko NaitoQ114019319
P2093author name stringKoji Nakayama
Yoshimitsu Abiko
Atsutoshi Yoshimura
Yoshitaka Hara
Mami Kishimoto
Koki Haruyama
P2860cites workDetermination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalisQ22066058
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signalingQ24675633
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83Q24682539
Use of T7 RNA polymerase to direct expression of cloned genesQ27860692
Trimeric structure of major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis.Q30160350
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalisQ33716115
A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalisQ36962002
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 productionQ39655172
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signalingQ40290129
Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transductionQ41007872
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasionQ41050913
Effects of various growth conditions in a chemostat on expression of virulence factors in Porphyromonas gingivalisQ41891881
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.Q42157652
Separation of the outer membrane and identification of major outer membrane proteins from Porphyromonas gingivalisQ43995544
Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activationQ44038231
Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis.Q51194193
Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalisQ64449894
Degradation of human immunoglobulins G and M and complement factors C3 and C5 by black-pigmented BacteroidesQ70052165
Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsivenessQ73910774
Haemoglobin receptor protein is intragenically encoded by the cysteine proteinase-encoding genes and the haemagglutinin-encoding gene of Porphyromonas gingivalisQ74183899
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal diseaseQ77746244
Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagAQ77863752
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalisQ78109544
Prevalence of Porphyromonas gingivalis in relation to periodontal status assessed by real-time PCRQ80488589
Occurrence of Porphyromonas gingivalis and Tannerella forsythensis in periodontally diseased and healthy subjectsQ80802652
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
NF-κBQ411114
Porphyromonas gingivalisQ3214147
P304page(s)4414-4420
P577publication date2009-08-10
P1433published inInfection and ImmunityQ6029193
P1476titleIdentification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells
P478volume77

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cites work (P2860)
Q53061256Analysis of a Lys-specific serine endopeptidase secreted via the type IX secretion system in Porphyromonas gingivalis.
Q44705620Identification of Porphyromonas gingivalis proteins secreted by the Por secretion system
Q45733195IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites
Q34674481Prevalence of Porphyromonas gingivalis four rag locus genotypes in patients of orthodontic gingivitis and periodontitis
Q49995246Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis

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