Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis

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Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.6600N
P356DOI10.1371/JOURNAL.PONE.0006600
P932PMC publication ID2719911
P698PubMed publication ID19672303
P5875ResearchGate publication ID26733805

P50authorYoshihiko HoshinoQ59096932
Michael WeidenQ59747757
William N. RomQ65029962
Bushra NaveedQ124714205
Anna NolanQ28360246
Jeffrey GoldQ42708202
P2093author name stringHiroshi Kobayashi
Ann Kelly
Satomi Hoshino
Matthew R Karulf
P2860cites workHuman B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptorsQ56909582
Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and punctureQ71580295
Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and punctureQ73440022
Combination immunotherapy with soluble tumor necrosis factor receptors plus interleukin 1 receptor antagonist decreases sepsis mortalityQ73928145
Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in miceQ77158141
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study GroupQ77292359
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsisQ79755036
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care MedicineQ22306067
IRAK-M is a negative regulator of Toll-like receptor signalingQ24302640
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
Exogenous interferon-alpha and interferon-gamma increase lethality of murine inhalational anthraxQ28396400
The epidemiology of sepsis in the United States from 1979 through 2000Q29547760
The pathophysiology and treatment of sepsisQ29619103
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412Q29622893
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcomeQ30438117
Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathwayQ34005152
The B7-CD28 superfamilyQ34575331
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kineticsQ34738334
CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunityQ35011537
What's the difference between CD80 and CD86?Q35155949
Protection against lethal toxic shock by targeted disruption of the CD28 geneQ36366867
CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsisQ36414862
Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 responseQ36477372
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.Q39907809
Affinity and epitope profiling of mouse anti-CD40 monoclonal antibodiesQ40641958
OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infectionQ40907799
Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growthQ44049991
CTLA-4-Ig regulates tryptophan catabolism in vivo.Q44170968
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator GroupQ44267568
Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosisQ44672416
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86.Q45092706
CD80/CD86 costimulation regulates acute vascular rejectionQ46764019
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
P304page(s)e6600
P577publication date2009-08-12
P1433published inPLOS OneQ564954
P1476titleDifferential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis
P478volume4

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