Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

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Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1048889293
P356DOI10.1186/1475-2875-9-51
P932PMC publication ID2833169
P698PubMed publication ID20149249
P5875ResearchGate publication ID41423660

P50authorDiana CaridhaQ91612250
Peter WipfQ29447250
P2093author name stringLucia Gerena
Victor Melendez
Charlotte Lanteri
Norma Roncal
Jason Sousa
Erin Milner
Sean Gardner
Duane Goodine
Geoffrey Stuart Dow
Jayendra Bhonsle
Jose Cobar
William McCalmont
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Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberQ29615128
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution techniqueQ29616826
Drug-like properties and the causes of poor solubility and poor permeabilityQ30660926
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparumQ33526131
CNS drug design based on principles of blood-brain barrier transportQ34066442
Mefloquine induces dose-related neurological effects in a rat modelQ34509705
Utility of alkylaminoquinolinyl methanols as new antimalarial drugsQ35215427
In silico prediction of blood–brain barrier permeationQ35557423
Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycinQ36424992
The IPTi Consortium: research for policy and actionQ36483773
Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of HelsinkiQ37052790
Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adultsQ39392887
In vitro activities of and mechanisms of resistance to antifol antimalarial drugsQ39849631
Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.Q40476822
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.Q40689125
A nuclear magnetic resonance study of the interactions of the antimalarials chloroquine, quinacrine, quinine and mefloquine with dipalmitoylphosphatidylcholine bilayersQ41945536
Drug-free holidays: pre-travel versus during travel malaria chemoprophylaxisQ47837595
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P921main subjectmalariaQ12156
P304page(s)51
P577publication date2010-02-11
P1433published inMalaria JournalQ15749954
P1476titleAnti-malarial activity of a non-piperidine library of next-generation quinoline methanols
P478volume9

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cites work (P2860)
Q413712474-Chloro-2,5-dimethyl-quinoline
Q34665879A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Q35081895Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice
Q38472391Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum
Q41920365Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations
Q41930137Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action
Q33916111Expanding the Antimalarial Drug Arsenal-Now, But How?
Q37334397Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration
Q39530026Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
Q37979631Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
Q34293304Mass administration of the antimalarial drug mefloquine to Guantánamo detainees: a critical analysis
Q38911151Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis
Q41928981New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents.
Q57013585Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantrine
Q33654562Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria
Q38439588The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models

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