New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents.

scientific article published on 10 July 2012

New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES17078285
P932PMC publication ID6268855
P698PubMed publication ID22781441
P5875ResearchGate publication ID229064131

P50authorAlessandra L ValverdeQ80826329
Antoniana KrettliQ102136512
Nubia BoechatQ47697925
P2093author name stringCarolina C P Costa
Monica M Bastos
Anna C C Aguiar
Sergio Pinheiro
Angelo C Pinto
Isabela P Ceravolo
Osvaldo A Santos-Filho
Luiz C S Pinheiro
Thiago S Silva
Alcione S Carvalho
Jorge S Mendonça
Karen D B Dutra
P2860cites workPlasmodium falciparum: cloning by single-erythrocyte micromanipulation and heterogeneity in vitroQ68136903
Fluorine in medicinal chemistryQ80497522
Fluorine in pharmaceuticals: looking beyond intuitionQ27648640
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsQ27656755
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialQ27670499
Human malaria parasites in continuous cultureQ28131626
Synchronization of Plasmodium falciparum Erythrocytic Stages in CultureQ29547549
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution techniqueQ29616826
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliabilityQ29617252
Anti-malarial activity of a non-piperidine library of next-generation quinoline methanolsQ33530732
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapyQ33903812
Malaria in Brazil: an overviewQ33939774
Metabolism of fluorine-containing drugsQ34192741
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in miceQ35071496
Synthesis and evaluation of naphthyridine compounds as antimalarial agentsQ36130640
Novel approaches to antimalarial drug discoveryQ36514205
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Q37057973
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceQ37352712
Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.Q37358401
Testing of natural products and synthetic molecules aiming at new antimalarials.Q37411279
Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and developmentQ37587440
Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II.Q39307596
Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivoQ39759075
Synthesis and antimalarial activity of new analogues of amodiaquineQ40136130
Antimalarial activity of medicinal plants used in traditional medicine in S. Tomé and Príncipe islands.Q40582008
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activityQ41937512
Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in cultureQ41942798
Hydrogen-bonded chains in 5-methyl-2-trifluoromethyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one and hydrogen-bonded chains of rings in 5-amino-3-trifluoromethyl-1H-1,2,4-triazole-5-methyl-2-trifluoromethyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one (1/1Q45092120
Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysisQ45104903
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African childrenQ46182948
Novel amodiaquine congeners as potent antimalarial agentsQ46533648
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium falciparumQ311383
P304page(s)8285-8302
P577publication date2012-07-10
P1433published inMoleculesQ151332
P1476titleNew trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents
P478volume17

Reverse relations

cites work (P2860)
Q37026599Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites
Q34040586Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
Q38751600Microwave Assisted Synthesis of Pyrimidines in Ionic Liquid and Their Potency as Non-Classical Malarial Antifolates
Q38890601Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase
Q89578719Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty
Q46761559Synthesis and isomerization of some novel pyrazolopyrimidine and pyrazolotriazolopyrimidine derivatives.
Q40110889Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine.
Q44064717Ultrasound irradiation promotes the synthesis of new 1,2,4-triazolo[1,5-a]pyrimidine

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