Integrative meta-analysis of differential gene expression in acute myeloid leukemia

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Integrative meta-analysis of differential gene expression in acute myeloid leukemia is …
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scholarly articleQ13442814
meta-analysisQ815382

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P819ADS bibcode2010PLoSO...5.9466M
P356DOI10.1371/JOURNAL.PONE.0009466
P932PMC publication ID2830886
P698PubMed publication ID20209125
P5875ResearchGate publication ID41809740

P50authorJohn StamatoyannopoulosQ62565798
P2093author name stringBrady G Miller
P2860cites workPrediction of chemosensitivity for patients with acute myeloid leukemia, according to expression levels of 28 genes selected by genome-wide complementary DNA microarray analysisQ78658578
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levelsQ81455082
Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogeneticsQ95751079
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Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changesQ75436814
Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemiaQ77628547
Abnormal mRNA expression of ASPP members in leukemia cell linesQ51028650
Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese populationQ51585027
Lack of correct data format and comparability limits future integrative microarray researchQ51929145
Prognostically useful gene-expression profiles in acute myeloid leukemiaQ51999490
Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemiaQ53484315
The expression patterns of RGS transcripts in plateletsQ53585529
Identification of new classes among acute myelogenous leukaemias with normal karyotype using gene expression profiling.Q53879864
Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia.Q54632781
AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.Q54676893
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemiasQ57734345
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenanceQ58882381
Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: the significance of the stem-cell glycoprotein CD34 (My10)Q67677506
Correlation between CD34 expression and chromosomal abnormalities but not clinical outcome in acute myeloid leukemiaQ71733863
Expression of the interleukin-6 (IL-6), IL-6 receptor, and gp130 genes in acute leukemiaQ72699055
Identification of a gene expression signature associated with pediatric AML prognosisQ73372374
Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemiaQ73679008
Constitutive phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemiaQ73816390
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemiaQ24308678
A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifsQ24312979
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9Q24317238
ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesQ24671904
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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplicationsQ27851415
Molecular classification of cancer: class discovery and class prediction by gene expression monitoringQ27861072
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Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cellsQ28137796
Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell LeukemiaQ28245189
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALLQ28254962
Hox expression in AML identifies a distinct subset of patients with intermediate cytogeneticsQ28256635
Altered expression of immune defense genes in pilocytic astrocytomasQ28276426
Thromboxanes: synthase and receptorsQ28277535
RGS10 is a selective activator of G alpha i GTPase activityQ28287882
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferationQ28304818
GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genesQ29616254
Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus.Q30032682
Venn Mapping: clustering of heterologous microarray data based on the number of co-occurring differentially expressed genesQ30883294
Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.Q33231820
Proteomic analysis of acute myeloid leukemia: Identification of potential early biomarkers and therapeutic targetsQ33235659
Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemiaQ33868950
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1bQ33889059
Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profilesQ34098676
Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic proteinQ34189784
Hematopoietic prostaglandin D synthaseQ34219405
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromesQ34264317
Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cellsQ34301116
Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemiaQ34313643
Hypothalamic hormones a.k.a. hypothalamic releasing factors.Q34383347
Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents.Q34654390
Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesionQ34768320
???Q28145831
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?Q35615901
Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome predictionQ35848938
Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B studyQ35848995
Regulation of chemokine-induced lymphocyte migration by RGS proteinsQ35864175
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardizationQ36203024
List of lists-annotated (LOLA): a database for annotation and comparison of published microarray gene listsQ36248371
Versican: signaling to transcriptional control pathways.Q36538369
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.Q36639451
The role of HOX genes in malignant myeloid diseaseQ36719199
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospectsQ37041909
Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkersQ37113145
HOX expression patterns identify a common signature for favorable AML.Q37176769
Impact of new prognostic markers in treatment decisions in acute myeloid leukemiaQ37495374
Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemiaQ38301992
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significanceQ38321981
Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia.Q38331348
Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomesQ38338957
Differential expression of drug-resistance-related genes between sensitive and resistant blasts in acute myeloid leukemiaQ38435287
Gene expression profile related to prognosis of acute myeloid leukemiaQ40056525
Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cellsQ40091503
Identification of genes with abnormal expression changes in acute myeloid leukemiaQ40168272
Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiationQ40313979
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.Q40471481
In vitro studies on Itm2a reveal its involvement in early stages of the chondrogenic differentiation pathwayQ40523162
Molecular characterization of acute leukemias by use of microarray technologyQ40582234
Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.Q40673679
Serum nm23-H1 protein as a prognostic factor in hematological malignanciesQ40713872
Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation.Q41418587
Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitorsQ42521206
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cellsQ42600565
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogeneticsQ44034346
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemiaQ44646947
Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemiaQ44740278
Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotypeQ45240539
Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressureQ46679983
Gene expression profiling of pediatric acute myelogenous leukemiaQ47266175
Large matrix proteoglycans, versican and perlecan, are expressed and secreted by human leukemic monocytesQ47680787
Genome‐wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation‐mediated fusion eventsQ47973072
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectacute myeloid leukemiaQ264118
meta-analysisQ815382
leukemiaQ29496
P304page(s)e9466
P577publication date2010-03-01
P1433published inPLOS OneQ564954
P1476titleIntegrative meta-analysis of differential gene expression in acute myeloid leukemia
P478volume5

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cites work (P2860)
Q38695117A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.
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Q36537783Exact statistical tests for the intersection of independent lists of genes
Q84356797FLT3-ITD-associated gene-expression signatures in NPM1-mutated cytogenetically normal acute myeloid leukemia
Q35114704Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes.
Q33967961Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets
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Q36309654Large-scale gene network analysis reveals the significance of extracellular matrix pathway and homeobox genes in acute myeloid leukemia: an introduction to the Pigengene package and its applications
Q34512638Meta-analysis of gene expression signatures reveals hidden links among diverse biological processes in Arabidopsis
Q92914012Multi-study reanalysis of 2,213 acute myeloid leukemia patients reveals age- and sex-dependent gene expression signatures
Q92996721Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies
Q53073364Novel t(7;10)(p22;p24) along with NPM1 mutation in patient with relapsed acute myeloid leukemia
Q28749098Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data
Q34128287Robust rank aggregation for gene list integration and meta-analysis
Q36126146Using Bioinformatic Approaches to Identify Pathways Targeted by Human Leukemogens

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