Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

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Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKW1149
P932PMC publication ID5388397
P698PubMed publication ID28180291

P50authorAndrei ChabesQ41166314
P2093author name stringPolina V Shcherbakova
Peter M J Burgers
Olga V Kochenova
Phong Tran
Alena V Makarova
Rachel Bezalel-Buch
P2860cites workInteractions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Q24291530
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zetaQ24323043
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisQ24594244
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
Eukaryotic DNA polymerase ζQ27011365
Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.Q27930712
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesisQ27934540
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressorQ27935222
Unique error signature of the four-subunit yeast DNA polymerase epsilonQ27935855
DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance.Q45972378
Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivoQ46493055
Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.Q46736951
Inhibition of ribonucleoside diphosphate reductase by hydroxyureaQ47808148
Molecular cloning, expression and chromosomal localisation of the mouse Rev3l gene, encoding the catalytic subunit of polymerase zetaQ47975722
Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.Q53062576
Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex.Q54285376
Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae.Q54503586
Analyzing fidelity of DNA polymerases.Q54619712
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage responseQ57964115
Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerasesQ71239708
DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiaeQ73406613
Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Q27937434
Role of DNA polymerase eta in the bypass of a (6-4) TT photoproductQ27939380
DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δQ28263318
Interaction of hREV1 with three human Y-family DNA polymerasesQ28266239
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl proteinQ28283240
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damageQ28343318
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zetaQ28354217
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sitesQ28363488
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageQ28507940
A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stabilityQ28534685
Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelityQ28542499
Recombinant replication protein A: expression, complex formation, and functional characterizationQ29615758
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
Ribonucleotide incorporation by yeast DNA polymerase ζ.Q31154777
RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta.Q33255508
The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.Q33257520
Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiaeQ33628462
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Q33957827
The effects of three PSO genes on induced mutagenesis : a novel class of mutationally defective yeast.Q34004091
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domainQ34097492
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damageQ34246788
Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanineQ34473133
The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significantQ34477514
Mechanisms of mutagenesis in vivo due to imbalanced dNTP poolsQ34609166
A novel function of DNA polymerase zeta regulated by PCNA.Q35040027
Lesion bypass by S. cerevisiae Pol ζ alone.Q35136551
The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesisQ35311897
Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coliQ35585702
The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sitesQ35588130
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelityQ35616094
dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variantsQ35616117
Compilation and alignment of DNA polymerase sequencesQ35774285
Cellular functions of DNA polymerase zeta and Rev1 proteinQ35978838
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ.Q36140297
Mutational specificity and genetic control of replicative bypass of an abasic site in yeastQ36446106
A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesisQ36478058
Mutational consequences of dNTP pool imbalances in E. coli.Q36501486
Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilonQ36573422
Extreme dNTP pool changes and hypermutability in dcd ndk strains.Q36578776
Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.Q36627910
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.Q36740419
Resolving individual steps of Okazaki-fragment maturation at a millisecond timescaleQ36873034
Proficient Replication of the Yeast Genome by a Viral DNA PolymeraseQ36941096
Nucleotide deficiency promotes genomic instability in early stages of cancer developmentQ37087191
Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase deltaQ37239015
The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesisQ37302944
Hypermutability and error catastrophe due to defects in ribonucleotide reductaseQ37319784
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structuresQ37416977
Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypassQ37612640
Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cellsQ37793347
Surviving chromosome replication: the many roles of the S-phase checkpoint pathwayQ37956284
Overproduction in Escherichia coli and characterization of yeast replication factor C lacking the ligase homology domainQ38312535
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zetaQ38326585
Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluoreneQ39095697
Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.Q39125049
Interactions between deoxyribonucleotide and DNA synthesisQ39532113
Compilation, alignment, and phylogenetic relationships of DNA polymerasesQ40405362
dNTP pools determine fork progression and origin usage under replication stressQ41166217
The origin of spontaneous mutation in Saccharomyces cerevisiae.Q41616101
The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesisQ41761731
Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair.Q42248736
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpointQ42738775
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.Q42950211
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductaseQ44311904
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1200-1218
P577publication date2017-02-01
P1433published inNucleic Acids ResearchQ135122
P1476titleYeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations
P478volume45

Reverse relations

cites work (P2860)
Q92606632DNA polymerase ζ in DNA replication and repair
Q52648657Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.
Q89473917Sml1 Inhibits the DNA Repair Activity of Rev1 in Saccharomyces cerevisiae during Oxidative Stress
Q47755642The CysB motif of Rev3p involved in the formation of the four-subunit DNA polymerase ζ is required for defective-replisome-induced mutagenesis
Q64236101The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity

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