Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate

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Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1128/CMR.12.3.367
P932PMC publication ID100243
P698PubMed publication ID10398670

P2093author name stringS Muralidhar
J Doniger
L J Rosenthal
P2860cites workThe regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutationsQ24296000
Wild-type p53 binds to the TATA-binding protein and represses transcriptionQ24300991
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigenQ24308837
Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigenQ24337366
Plaque-associated expression of human herpesvirus 6 in multiple sclerosisQ24564496
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Basic local alignment search toolQ25938991
A simple method for displaying the hydropathic character of a proteinQ26778481
Primary Characterization of a Herpesvirus Agent Associated with Kaposi’s SarcomaQ27636336
The retinoblastoma protein and cell cycle controlQ27860722
WAF1, a potential mediator of p53 tumor suppressionQ27861121
A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus Type 6 InfectionQ28208561
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD proteinQ28238628
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6Q28279600
Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other.Q39882060
Cytomegalovirus in Semen: Observations in Selected PopulationsQ39957658
Herpesvirus Antibodies and Antigens in Patients With Cervical Anaplasia and in Controls 2Q39958117
Oncogenic Transformation of Human Embryo Lung Cells by Human CytomegalovirusQ39991944
Identification and characterization of a human herpesvirus 6 gene segment capable of transactivating the human immunodeficiency virus type 1 long terminal repeat in an Sp1 binding site-dependent manner.Q40039602
Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein.Q40041760
The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.Q40043548
Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus.Q40059647
Inhibition of viral and cellular promoters by human wild-type p53Q40066650
Venereal Causes of Cytomegalovirus MononucleosisQ40092847
Evidence for the Association of Cytomegalovirus with Carcinoma of the ProstateQ40107635
Relation of Herpes Simplex Viruses to Human MalignanciesQ40111282
Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.Q40116280
Cytomegalovirus-leukocyte interactionsQ40142731
HSV, CMV, and HPV in Human NeoplasiaQ40143077
Association of Cytomegalovirus (CMV) Infection with Cervical Cancer: Isolation of CMV from Cell Cultures Derived from Cervical BiopsyQ40159686
Antibody patterns to herpesviruses in Kaposi's sarcoma. II. Serological association of american Kaposi's sarcoma with cytomegalovirusQ40178496
Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirusQ40249217
Cytomegalovirus Isolations from Cell Cultures of Human Adenocarcmomas of the ColonQ40289274
The retinoblastoma tumor suppressor protein.Q40605932
Herpesvirus particles in prostatic carcinoma cellsQ40638128
The tumor suppressor genesQ40856821
Cytomegalovirus infection in previously healthy adultsQ40910267
Human cytomegalovirus infection results in altered Cdk2 subcellular localizationQ41097052
Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection.Q41198290
Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivoQ41332093
RB kinases and RB-binding proteins: new points of viewQ41341093
Retinoblastoma protein in growth suppression and death protectionQ41345444
Modulatory effects of human cytomegalovirus infection on malignant properties of cancer cellsQ41392813
Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expressionQ41436909
Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SalI-L fragment of human herpesvirus 6.Q41467843
trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.Q41483343
Alteration in the coding potential and expression of H-ras in human cytomegalovirus-transformed cellsQ41495789
E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.Q41506160
Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).Q41612403
Activation of cellular oncogenes by clinical isolates and laboratory strains of human cytomegalovirusQ41672267
Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseasesQ41686769
Functional analysis of human cytomegalovirus morphological transforming region II (mtrll)Q41693515
Activation of Proto-Oncogenes: an Immediate Early Event in Human Cytomegalovirus InfectionQ41744434
Lack of association of cytomegalovirus with adenocarcinoma of the colonQ41881449
A 79 amino acid oncogene is responsible for human cytomegalovirus mtrII induced malignant transformationQ42596587
Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6Q42599565
Identification of two promoters within human cytomegalovirus morphologic transforming region II.Q42600922
Localization and sequence analysis of morphological transforming region III within human cytomegalovirus strain TowneQ42604143
An immediate early gene of human cytomegalovirus encodes a potential membrane glycoproteinQ42649036
A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.Q42800173
Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53.Q42804539
Growth regulation of a cellular tumour antigen, p53, in nontransformed cellsQ42819146
Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA.Q43450985
Isolation of a new virus, HBLV, in patients with lymphoproliferative disordersQ28282589
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcomaQ28284765
HBLV (or HHV-6) in human cell linesQ28302015
p53 mutations in human cancersQ28302973
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathwayQ28776004
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
A workbench for multiple alignment construction and analysisQ29618211
mdm2 expression is induced by wild type p53 activityQ29618316
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene productQ29618372
E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsQ29618375
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene productQ29620421
Analysis of a protein-binding domain of p53Q33292314
Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancerQ33581303
Localization and DNA sequence analysis of the transforming domain (mtrII) of human cytomegalovirusQ33637054
Multiple transforming regions of human cytomegalovirus DNA.Q33928670
Lipoproteins in bacteriaQ34660581
The PROSITE dictionary of sites and patterns in proteins, its current statusQ34990619
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients.Q35774050
High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosisQ35811381
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrestQ35849687
Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcriptionQ35873729
Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.Q35889716
PROSITE: a dictionary of sites and patterns in proteinsQ35921056
An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoterQ36069170
Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteinsQ36085322
In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6).Q36354976
Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infectionQ36364690
Long-term persistence of cytomegalovirus genome in cultured human cells of prostatic originQ36541283
Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblastsQ36637901
Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirusQ36653844
p53 domains: structure, oligomerization, and transformationQ36662699
Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start siteQ36680389
A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2Q36680417
Potential role of human cytomegalovirus and p53 interaction in coronary restenosisQ72041267
The domain of p53 required for binding HPV 16 E6 is separable from the degradation domainQ72520479
Cytomegalovirus and Kaposi's sarcoma in young homosexual menQ72528586
Cytomegalovirus/herpesvirus and carotid atherosclerosis: the ARIC StudyQ72774085
Mutations of the human cytomegalovirus immediate-early 2 protein defines regions and amino acid motifs important in transactivation of transcription from the HIV-1 LTR promoterQ72847572
Humoral- and cell-mediated immune responses to herpesvirus antigens in patients with cervical carcinoma☆☆☆Q72859193
Kaposi's sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsiesQ72915153
Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: demonstration of cytomegalovirus RNA in sarcoma cellsQ72958946
The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcriptionQ36685220
Transactivation of the cytomegalovirus ICP36 gene promoter requires the alpha gene product TRS1 in addition to IE1 and IE2Q36690662
Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoterQ36692142
Inhibition of DNA replication factor RPA by p53.Q36768122
Tumor progression mediated by two cooperating DNA segments of human cytomegalovirusQ36780366
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.Q36781988
The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap siteQ36796246
Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6Q36798152
Human herpesvirus 6 is closely related to human cytomegalovirus.Q36799320
Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteinsQ36803147
Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domainsQ36803353
Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoterQ36811230
Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene regionQ36828401
The human cytomegalovirus mtrII colinear region in strain Tanaka is transformation defective.Q36828941
Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1.Q36853873
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirusQ36865895
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumorsQ36895398
Structure of the transforming region of human cytomegalovirus AD169.Q36910762
Structural analysis of the major immediate early gene of human cytomegalovirusQ36911017
Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed CellsQ36966578
Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individualsQ37068178
Wild-type p53 is a cell cycle checkpoint determinant following irradiationQ37152060
Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IIDQ37531197
Neoplastic transformation by a cloned human cytomegalovirus DNA fragment uniquely homologous to one of the transforming regions of herpes simplex virus type 2Q37615632
Wild-type p53 can down-modulate the activity of various promotersQ37617210
Structural aspects of the p53 protein in relation to gene evolutionQ37856166
Viral T-antigen interactions with cellular proto-oncogene and anti-oncogene productsQ37872393
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.Q37879797
The cyclin E promoter is activated by human cytomegalovirus 86-kDa immediate early proteinQ38334420
Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcomaQ38888677
Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6.Q39195127
Human B-lymphotropic virus (human herpesvirus-6).Q39279861
Lymphocyte Reactivity against Virally Transformed Cells in Patients with Urologic CancerQ39458577
Cytomegalovirus D.N.A. and adenocarcinoma of the colon: Evidence for latent viral infectionQ39485494
Human cytomegalovirus IE1 and IE2 proteins block apoptosisQ39872769
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
Complement-fixation antibodies to adenovirus-associated viruses, cytomegaloviruses and herpes simplex viruses in patients with tumors and in control individualsQ43752403
Cytomegalovirus retinitis and acquired immunodeficiency syndromeQ43761529
Meningo-encephalitis associated with HHV-6 related exanthem subitumQ44662077
Human herpesvirus 6 and exanthem subitumQ44758248
Fatal fulminant hepatitis in an infant with human herpesvirus-6 infectionQ44779958
Demonstration of cytomegalovirus in semenQ44865432
Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reactionQ45006318
Cervical carcinoma: Detection of herpes simplex virus RNA in cells undergoing neoplastic changeQ45803424
Human cytomegalovirus and herpes simplex type 2 virus in normal and adenocarcinomatous prostate glandsQ45804849
Occurrence of herpes- and adenovirus antibodies in patients with carcinoma of the cervix uteri. Measurement of antibodies to herpesvirus hominis (types 1 and 2), cytomegalovirus, EB-virus, and adenovirusQ45820522
Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patientsQ45832982
Genomic analysis of the human B-lymphotropic virus (HBLV).Q45836010
Analysis of human KS biopsies and cloned cell lines for cytomegalovirus, HIV-1, and other selected DNA virus sequencesQ45846090
The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (HHV-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirusQ45851408
Cellular oncogene activation by human cytomegalovirus Lack of correlation with virus infectivity and immediate early gene expressionQ45859711
Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosisQ45862758
Prevalence of Cytomegalovirus Infection in Homosexual MenQ46032258
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factorQ46050449
Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirusQ48356320
Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factorQ52480364
p53 domains: identification and characterization of two autonomous DNA-binding regions.Q52544476
Transcriptional activation by p53 correlates with suppression of growth but not transformation.Q53468212
Modulation of MHC antigen expression by viruses and oncogenesQ53495242
Cytomegalovirus infection and viral-induced transformation of human endothelial cells.Q53522102
Cytomegalovirus and carcinogenesisQ53553430
Kaposi's sarcoma and its relationship to cytomegalovirus (CMNV). III. CMV DNA and CMV early antigens in Kaposi's sarcoma.Q53959716
Breast Milk and the Risk of Cytomegalovirus InfectionQ56431619
Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the NasopharynxQ56689988
Binding of general transcription factor TFIIB to an acidic activating regionQ59058683
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIIDQ59070657
Cytomegalovirus DNA in arterial walls of patients with atherosclerosisQ63983747
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsQ64381309
Alterations in biological properties of different lines of cytomegalorivus-transformed human embryo lung cells following in vitro cultivationQ66850157
Presence of antibodies to human cytomegalovirus in patients with different forms of cancer and in other categories of subjectsQ67240355
Lack of Association of Cytomegalovirus Antibody Level with Carcinoma of the Uterine CervixQ67245499
Infectious Diseases Society of America and Centers for Disease Control: Summary of a Workshop on Surveillance for Congenital Cytomegalovirus DiseaseQ68238555
Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantationQ68307767
Oncogenic potential of human herpesvirus-6 DNAQ68480867
Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin's lymphomaQ68491462
Cytomegalovirus antibody in patients with carcinoma of the uterine cervixQ68630700
Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirusQ68666577
Identification of human herpesvirus-6 as a causal agent for exanthem subitumQ69917877
Detection of sequences that hybridize to human cytomegalovirus DNA in cervical neoplastic tissueQ69919578
Clinical and serological features of human herpesvirus-6 infection in three adultsQ69924845
Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcomeQ70148540
Widespread presence of histologically occult cytomegalovirusQ70213149
Herpesvirus Infections in the Acquired Immune Deficiency SyndromeQ70214424
Absence of cytomegalovirus DNA from adenocarcinoma of the colonQ70796602
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
Human herpesvirus 6Q6974
P304page(s)367-382
P577publication date1999-07-01
P1433published inClinical Microbiology ReviewsQ5133777
P1476titleHuman cytomegalovirus and human herpesvirus 6 genes that transform and transactivate
P478volume12

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