Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein.

scientific article published on October 1994

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID237042
P698PubMed publication ID8083962

P2093author name stringD H Spector
M H Sommer
A L Scully
P2860cites workDefinition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene productQ24304934
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycleQ24319785
The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIBQ24563487
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
Temporal Patterns of Human Cytomegalovirus Transcription: Mapping the Viral RNAs Synthesized at Immediate Early, Early, and Late Times After InfectionQ28264539
Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associationsQ29620211
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene productQ29620421
Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteinsQ34352327
Cyclin A and the retinoblastoma gene product complex with a common transcription factorQ34756189
An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoterQ36069170
TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A proteinQ36535897
Stimulation of cellular DNA synthesis by human cytomegalovirusQ36556598
Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteinsQ36651434
Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirusQ36653844
The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signalQ36701599
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.Q36781988
Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteinsQ36803147
Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domainsQ36803353
Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoterQ36811230
Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1.Q36853873
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirusQ36865895
Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene.Q36872629
Structural analysis of the major immediate early gene of human cytomegalovirusQ36911017
Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IIDQ37531197
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma proteinQ38319003
E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infectionQ38325725
A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a proteinQ38340347
Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivationQ38347799
The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.Q40043548
Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domainQ40048677
The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.Q40066427
In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.Q41576192
Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169.Q43820771
The Drosophila glutathione S-transferase 1-1 is encoded by an intronless gene at 87B.Q43988476
Characterization of a variant rat glutathione S-transferase by cDNA expression in Escherichia coliQ45164448
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factorQ46050449
Binding of general transcription factor TFIIB to an acidic activating regionQ59058683
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIIDQ59070657
The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulatioQ72696029
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
retinoblastomaQ500695
P304page(s)6223-6231
P577publication date1994-10-01
P1433published inJournal of VirologyQ1251128
P1476titleTransactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein
P478volume68

Reverse relations

cites work (P2860)
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