Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

scientific article

Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01748-09
P932PMC publication ID2798427
P698PubMed publication ID19846511

P2093author name stringKlaus Früh
Stefan Rothenburg
David Alvarado
Tina Sali
Victor R DeFilippis
P2860cites workComplex regulation of the human gene for the Z-DNA binding protein DLM-1.Q24292291
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-IQ24310238
Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAsQ24311713
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activationQ24315019
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateQ24315639
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activationQ24316038
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathwayQ24317317
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseQ24317784
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune responseQ24336273
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
Innate immune recognition of viral infectionQ24498364
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.Q24533140
Antiviral actions of interferonsQ24550676
Innate cellular response to virus particle entry requires IRF3 but not virus replicationQ24607212
The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genesQ24607496
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNAQ24634416
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3Q28141455
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Triggering the interferon antiviral response through an IKK-related pathwayQ28191761
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivoQ28609049
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalingQ28646137
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunityQ29615913
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domainsQ30478275
The IFN-independent response to virus particle entry provides a first line of antiviral defense that is independent of TLRs and retinoic acid-inducible gene I.Q45409957
Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential displayQ47910612
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.Q54631516
A subset of viral transcripts packaged within human cytomegalovirus particlesQ73943063
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivoQ81447079
Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblastsQ33787378
Herpes simplex virus triggers and then disarms a host antiviral responseQ33835458
Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAsQ33870381
Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathwayQ33957986
Do pathogens accelerate atherosclerosis?Q34389205
A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signalingQ34944144
Toll receptors and pathogen resistanceQ35076745
The host type I interferon response to viral and bacterial infectionsQ36178864
Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B.Q36295396
Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems.Q36315245
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing moleculesQ36535512
Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arraysQ36736217
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.Q36742231
Signaling pathways downstream of pattern-recognition receptors and their cross talkQ36747486
Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune responseQ36898663
Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.Q36949602
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signalingQ37000233
Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon responseQ37568171
Congenital and perinatal cytomegalovirus infectionsQ37897929
Human cytomegalovirus IE86 attenuates virus- and tumor necrosis factor alpha-induced NFkappaB-dependent gene expressionQ39291106
Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complexQ39575110
Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirusQ39603963
Differential modification of interferon regulatory factor 3 following virus particle entryQ39884810
IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).Q39943290
Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cellsQ40000308
Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expressionQ40130383
EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.Q40237206
Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virionsQ40340459
Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replicationQ40416407
Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B.Q40468638
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta inductionQ40675827
Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirusQ40887036
Cytomegalovirus infections in transplant patients.Q41154225
Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3.Q41885111
Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon productionQ41886260
A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferonQ42096820
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon productionQ42408427
Episomal vectors rapidly and stably produce high-titer recombinant retrovirusQ42810400
Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infectionQ43181876
Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signalingQ44318736
Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcriptionQ44445912
Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions.Q45201933
P433issue1
P921main subjectCytomegalovirusQ6946
P304page(s)585-598
P577publication date2010-01-01
P1433published inJournal of VirologyQ1251128
P1476titleHuman cytomegalovirus induces the interferon response via the DNA sensor ZBP1.
P478volume84

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cites work (P2860)
Q36266860A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection
Q30145658A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses
Q54960967A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.
Q36084979A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.
Q38366522A proteomics perspective on viral DNA sensors in host defense and viral immune evasion mechanisms.
Q35347846A temporal gate for viral enhancers to co-opt Toll-like-receptor transcriptional activation pathways upon acute infection
Q41665315Abrogation of the interferon response promotes more efficient human cytomegalovirus replication
Q24293059Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication
Q39688943Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.
Q21559401BST2/Tetherin enhances entry of human cytomegalovirus
Q36528505Bacterial Muramyl Dipeptide (MDP) Restricts Human Cytomegalovirus Replication via an IFN-β-Dependent Pathway
Q28551420Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses
Q33850280Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR
Q24606603Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff
Q38379995Cytomegalovirus immune evasion of myeloid lineage cells
Q33351523Cytomegalovirus: pathogen, paradigm, and puzzle
Q42036855DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.
Q89896482DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs
Q38097227DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication
Q36667834DNA sensing-independent inhibition of herpes simplex virus 1 replication by DAI/ZBP1
Q35076832Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1
Q41867125Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways
Q47269135Emerging Alphaviruses are Sensitive to Cellular States Induced by a Novel Small Molecule Agonist of the STING Pathway
Q41923781Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways
Q33872793Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription
Q90724306Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition
Q35115583Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways
Q41919640Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction
Q63246481Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome
Q47215649Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses
Q45317065IRF3 mediated activation of type 1 IFN
Q26746467Immune Activation in the Liver by Nucleic Acids
Q38109307Immune sensing of DNA
Q58762327Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage
Q37982838Induction and function of IFNβ during viral and bacterial infection
Q37756215Induction of type I interferons by bacteria
Q59351679Innate Sensing of DNA Virus Genomes
Q28080982Innate immune recognition of DNA: A recent history
Q24626598Innate immune sensing of DNA viruses
Q37655207Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome
Q54597465Interaction of the human cytomegalovirus particle with the host cell induces hypoxia-inducible factor 1 alpha.
Q92538369Interferon-Independent Innate Responses to Cytomegalovirus
Q64106132Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression
Q38018936Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship.
Q26997316Intracellular nucleic acid sensors and autoimmunity
Q54221793Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters.
Q36807121Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines
Q36827145Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus
Q35886583Mechanisms and pathways of innate immune activation and regulation in health and cancer
Q36736620Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry
Q34975235Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway
Q38299880Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection
Q54254744Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
Q34194312Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine
Q91670491Post-translational Control of Innate Immune Signaling Pathways by Herpesviruses
Q39036428Protect this house: cytosolic sensing of viruses
Q38547052RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity.
Q34349745Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases
Q27000358Recognition of cytosolic DNA by cGAS and other STING-dependent sensors
Q36939781Recognition of herpesviruses by the innate immune system
Q39360861Regulating STING in health and disease
Q93096532Regulation of signaling mediated by nucleic acid sensors for innate interferon-mediated responses during viral infection
Q37473694Role of nucleotide-binding oligomerization domain 1 (NOD1) and its variants in human cytomegalovirus control in vitro and in vivo.
Q34317532STING and the innate immune response to nucleic acids in the cytosol
Q34265452STING mediates neuronal innate immune response following Japanese encephalitis virus infection
Q37794828Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors.
Q37948677Sensing herpes: more than toll
Q26799867Sensors of Infection: Viral Nucleic Acid PRRs in Fish
Q37827868Sources and signals regulating type I interferon production: lessons learned from cytomegalovirus
Q78177266Subclinical in utero Zika virus infection is associated with interferon alpha sequelae and sex-specific molecular brain pathology in asymptomatic porcine offspring.
Q35561085Suppression of RIP3-dependent necroptosis by human cytomegalovirus
Q64106832The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways
Q47269122The Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING.
Q58334287The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling
Q37887501The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses
Q47108243The influence of HCMV infection on autophagy in THP-1 cells
Q92861156The molecular machinery of regulated cell death
Q37395985The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus
Q37603408True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity
Q55334528Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation.
Q90167808UL26 Attenuates IKKβ-Mediated Induction of Interferon-Stimulated Gene (ISG) Expression and Enhanced Protein ISGylation during Human Cytomegalovirus Infection
Q27010127Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
Q40812884Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade
Q38114974Viral modulation of programmed necrosis
Q37856429Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?
Q58725930Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
Q61458334Z-DNA and Z-RNA in human disease
Q90400859Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis
Q90482828ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling
Q45317064ZBP1(DAI) mediated induction of type I IFNs
Q37461770ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
Q28954543Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Q35983493cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
Q37182691cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
Q90258585microRNA-221 restricts human cytomegalovirus replication via promoting type I IFN production by targeting SOCS1/NF-κB pathway

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