Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism

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Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism is …
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scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1275441L
P356DOI10.1371/JOURNAL.PONE.0175441
P932PMC publication ID5389842
P698PubMed publication ID28403174

P50authorChristian DrevonQ11963637
P2093author name stringAnna Krook
Arild C Rustan
G Hege Thoresen
Jørgen Jensen
Hans K Stadheim
Kåre I Birkeland
Camilla Stensrud
Eili T Kase
Yuan Z Feng
Hanne L Gulseth
Torgrim M Langleite
Jonathan M Mudry
Jenny Lund
Nils G Løvsletten
Daniel S Tangen
Kristoffer J Kolnes
Egil I Johansen
Mari G Brubak
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PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolismQ34230877
Acute exercise remodels promoter methylation in human skeletal muscle.Q34260142
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The Respiratory Exchange Ratio is Associated with Fitness Indicators Both in Trained and Untrained Men: A Possible Application for People with Reduced Exercise Tolerance.Q34342630
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Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise interventionQ34631881
Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cellsQ35195606
Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjectsQ35195718
Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acidsQ35901254
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PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humansQ36658412
Skeletal muscle insulin resistance: roles of fatty acid metabolism and exerciseQ36965630
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Insulin responsiveness in metabolic syndrome after eight weeks of cycle trainingQ37239420
Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging.Q37580100
Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscleQ37603805
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Are cultured human myotubes far from home?Q38113149
Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exerciseQ41548294
Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acidQ41982943
Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humansQ42065841
Physical activity is associated with retained muscle metabolism in human myotubes challenged with palmitate.Q42440108
Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell culturesQ42480893
Metabolic flexibility is conserved in diabetic myotubesQ42503208
A cellular model system of differentiated human myotubesQ43921005
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.Q44240302
Exercise increases nuclear AMPK alpha2 in human skeletal muscle.Q44381185
Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise trainingQ45014251
Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathwayQ46406553
Skeletal muscle lipid oxidation and obesity: influence of weight loss and exerciseQ47248288
Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery.Q50568528
The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus.Q51377692
Response rates with different distribution methods and reward, and reproducibility of a quantitative food frequency questionnaire.Q52194328
Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men.Q53765535
Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals.Q54281224
PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference.Q54412001
Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitusQ58449812
Proliferation conditions for human satellite cells The fractional content of satellite cellsQ58456168
Exercise and the Treatment of Diabetes and ObesityQ61908380
Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjectsQ71655107
Glucose oxidation and replacement during prolonged exercise in manQ72317273
22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubesQ79285508
Cell-based multiwell assays for the detection of substrate accumulation and oxidationQ79528589
International Diabetes Federation: a consensus on Type 2 diabetes preventionQ80241108
Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individualsQ80695266
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)e0175441
P577publication date2017-04-12
P1433published inPLOS OneQ564954
P1476titleExercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism
P478volume12

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cites work (P2860)
Q88688710Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes
Q50237618Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects
Q59796242Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects
Q57022882In vitro experimental models for examining the skeletal muscle cell biology of exercise: the possibilities, challenges and future developments
Q57168590Lifestyle Management of Diabetes: Implications for the Bone-Vascular Axis
Q96954758Mitochondrial Function in Muscle Stem Cell Fates
Q58546750Relationship Between Sitting Time, Physical Activity, and Metabolic Syndrome Among Adults Depending on Body Mass Index (BMI)

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