Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides

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Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides is …
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scholarly articleQ13442814

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P819ADS bibcode1988PNAS...85.1932P
P356DOI10.1073/PNAS.85.6.1932
P932PMC publication ID279895
P698PubMed publication ID2450351
P5875ResearchGate publication ID20706485

P50authorBarton HaynesQ4865631
Kent J. WeinholdQ109935303
Dani BolognesiQ109936341
T J PalkerQ125313333
P2093author name stringT J Matthews
A J Langlois
M E Clark
R R Randall
P2860cites workGenomic heterogeneity of AIDS retroviral isolates from North America and Zaire.Q53896192
Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Q22242256
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteinsQ28240446
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusQ28259668
Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSQ28262859
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptorQ28646793
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 moleculeQ28646808
Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1Q28646812
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVQ28646817
Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSQ29614260
Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.Q30355613
Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions.Q30356755
Induction of anti-HIV neutralizing antibodies by synthetic peptidesQ33880796
Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDSQ34250436
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitopeQ34614992
Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptideQ34632476
Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteinsQ35076867
Hydrophobic basis of packing in globular proteinsQ36401816
Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibodyQ37399845
Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoproteinQ37412527
Variable and conserved neutralization antigens of human immunodeficiency virusQ38891686
Expression of the HTLV-III envelope gene by a recombinant vaccinia virusQ39500655
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigenQ41830365
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicityQ43894349
Use of a resin-bound synthetic peptide for identifying a neutralizing antigenic determinant associated with the human immunodeficiency virus envelopeQ44207603
Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoproteinQ44509170
Immunogenic structure of the influenza virus hemagglutininQ45805278
Expression of AIDS virus envelope gene in recombinant vaccinia virusesQ45837045
Genomic diversity of human T-lymphotropic virus type III (HTLV-III).Q45838359
HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelopeQ45848174
Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patientsQ45848343
Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS.Q48363856
Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.Q53534022
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
antibodyQ79460
P1104number of pages5
P304page(s)1932-1936
P577publication date1988-03-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleType-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides
P478volume85

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Q37239053Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1
Q37084521Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses
Q41667538Soluble CD4-PE40 Is Cytotoxic for a Transfected Mammalian Cell Line Stably Expressing the Envelope Protein of Human Immunodeficiency Virus (HIV-1), and Cytotoxicity Is Variably Inhibited by the Sera of HIV-1-Infected Patients
Q44244988Solution Structure of an Antibody-Bound HIV-1(IIIB) V3 Peptide: A Cis Proline Turn Linking Two β-hairpin Strands
Q45967960Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125.
Q36884458Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodies
Q36644697Specificity of antibodies produced against native or desialylated human immunodeficiency virus type 1 recombinant gp160
Q27658173Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens
Q31112947Structural analysis of the HIV-1 gp120 V3 loop: application to the HIV-Haiti isolates
Q44279032Structure and polymorphism of the principal neutralization site of Thailand HIV-1 isolate
Q35879339Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant
Q30238730Survivors Remorse: antibody-mediated protection against HIV-1.
Q28324011Synergistic combinations and peptides in the inhibition of human immunodeficiency virus
Q38665396Synthetic T and B cell recognition sites: implications for vaccine development
Q28369122Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of human immunodeficiency virus type 1 (HIV-1) gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-negative mucosal epithelial cell line
Q40484822Synthetic peptides as diagnostic tools in virology.
Q57607867Synthetic peptides representing sequences within gp41 of HIV as immunogens for murine T- and B-cell responses
Q42550971Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry
Q39189758The N-linked glycan of the V3 region of HIV-1 gp120 and CXCR4-dependent multiplication of a human immunodeficiency virus type 1 lymphocyte-tropic variant.
Q40433970The Role of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in Virus Infection
Q38949380The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
Q36055538The auto-regulation model: a unified concept of how HIV regulates its infectivity, pathogenesis and persistence
Q74248184The binding of a glycoprotein 120 V3 loop peptide to HIV-1 neutralizing antibodies. Structural implications
Q30769950The capsid gene of feline calicivirus contains linear B-cell epitopes in both variable and conserved regions
Q38366893The immunopathogenesis of HIV infection
Q37388157The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.
Q36704527The molecular structure of human antibodies specific for the human immunodeficiency virus
Q36839199The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1
Q40354016The quest for an antibody-based HIV vaccine
Q36809662The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope
Q36954472The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.
Q73935005Thermodynamic analysis of the interaction between the 0.5beta Fv fragment and the RP135 peptide antigen derived from the V3 loop of HIV-1 gp120
Q44745703Towards covalent vaccination: improved polyclonal HIV neutralizing antibody response induced by an electrophilic gp120 V3 peptide analog
Q37924787Use of deuterium labelling in NMR studies of antibody combining site structure
Q41035907V3 Region Polymorphisms in HIV-1 from Brazil: Prevalence of Subtype B Strains Divergent from North American/European Prototype and Detection of Subtype F
Q40047131V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability.
Q34171212V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Tria
Q33839402Vaccine-elicited V3 loop-specific antibodies in rhesus monkeys and control of a simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate envelope
Q34402934Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection
Q35848078Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1.
Q39591825Variability and immunogenicity of caprine arthritis-encephalitis virus surface glycoprotein
Q30417537Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France
Q36632917Variability of the env gene in cynomolgus macaques persistently infected with human immunodeficiency virus type 2 strain ben.
Q36353458Variants selected by treatment of human immunodeficiency virus-infected cells with an immunotoxin
Q36829102Variation in simian immunodeficiency virus env is confined to V1 and V4 during progression to simian AIDS.
Q33564746Vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain
Q45785271Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype

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